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Future Medicine, Pharmacogenomics, 6(17), p. 583-591, 2016

DOI: 10.2217/pgs.16.8

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A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering

Journal article published in 2016 by Maarten Leusink, Anke H. Maitland-Van der Zee, Bo Ding, Fotios Drenos, Erik Pa van Iperen, Helen R. Warren, Mark J. Caulfield, L. Adrienne Cupples ORCID, Mary Cushman, Aroon D. Hingorani, Ron C. Hoogeveen ORCID, G. Kees Hovingh, Meena Kumari ORCID, Leslie A. Lange, Patricia B. Munroe and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Aim: To find new genetic loci associated with statin response, and to investigate the association of a genetic risk score (GRS) with this outcome. Patients & methods: In a discovery meta-analysis (five studies, 1991 individuals), we investigated the effects of approximately 50000 single nucleotide polymorphisms on statin response, following up associations with p < 1 × 10-4 (three independent studies, 5314 individuals). We further assessed the effect of a GRS based on SNPs in ABCG2, LPA and APOE. Results: No new SNPs were found associated with statin response. The GRS was associated with reduced statin response: 0.0394 mmol/l per allele (95% CI: 0.0171–0.0617, p = 5.37 × 10-4). Conclusion: The GRS was associated with statin response, but the small effect size (˜2% of the average low-density lipoprotein cholesterol reduction) limits applicability.