Published in
American Society of Hematology, Blood, 3(129), p. 371-382, 2017
DOI: 10.1182/blood-2016-09-739003
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CCL2 is a KIT D816V–dependent modulator of the bone marrow microenvironment in systemic mastocytosis
Journal article published in 2016 by
Georg Greiner,
Nadine Witzeneder,
Angelika Berger,
Klaus Schmetterer,
Gregor Eisenwort 
,
Ana-Iris Schiefer,
Simone Roos,
Theresia Popow-Kraupp,
Leonhard Müllauer,
Johannes Zuber,
Veronika Sexl,
Lukas Kenner,
Wolfgang R. Sperr,
Peter Valent,
Matthias Mayerhofer
and other authors.
,
Ana-Iris Schiefer,
Simone Roos,
Theresia Popow-Kraupp,
Leonhard Müllauer,
Johannes Zuber,
Veronika Sexl,
Lukas Kenner,
Wolfgang R. Sperr,
Peter Valent,
Matthias Mayerhofer
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key PointsCCL2 is a KIT D816V–induced cytokine targeting microenvironmental cells in mastocytosis in vitro and in vivo. Serum levels of CCL2 in patients with mastocytosis correlate with advanced disease and poor survival.