Published in
Oxford University Press (OUP), Brain, 4(142), p. 1024-1034
DOI: 10.1093/brain/awz034
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Dopamine Depletion Alters Macroscopic Network Dynamics in Parkinsons Disease
Journal article published in 2018 by
James M. Shine,
Peter T. Bell,
Elie Matar,
Russell A. Poldrack,
Simon Jg G. Lewis,
Glenda M. Halliday 
,
Claire O'Callaghan
,
Claire O'Callaghan
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Abstract
Using a dynamic graph theoretical approach, Shine et al. show that individuals with Parkinson’s disease demonstrate heightened network-level integration during the ‘Off’ state that is inversely correlated with motor symptom severity. Network-level integration relates to two measures of neurocognitive reserve, suggesting a protective function for ‘Off’ state integration.