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BioMed Central, Immunity and Ageing, 1(9), 2012

DOI: 10.1186/1742-4933-9-23

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CMV and Immunosenescence: from basics to clinics

Journal article published in 2012 by Rafael Solana, Raquel Tarazona, Allison E. Aiello, Arne N. Akbar, Victor Appay, Mark Beswick, Jos A. Bosch, Carmen Campos, Sara Cantisán, Luka Cicin-Sain, Evelyna Derhovanessian, Sara Cantis?n, Sara Ferrando-Martínez, Daniela Frasca, Tamas Fulöp and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates ???immunosenescence???. This contention remains controversial and was the primary subject of the Third International Workshop on CMV & Immunosenescence which was held in Cordoba, Spain, 15-16th March, 2012. Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization of CMV-specific T cells, impact of CMV infection and ageing on innate immunity, and finally, most important, the clinical implications of immunosenescence and CMV infection. Here we summarize the major findings of this workshop.