Published in
American Society of Hematology, Blood, p. blood-2018-05-849307
DOI: 10.1182/blood-2018-05-849307
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Platelets kill circulating parasites of all major Plasmodium species in human malaria
Journal article published in 2018 by
Steven Kho,
Bridget E. Barber 
,
Edison Johar,
Benediktus Andries ,
Jeanne R. Poespoprodjo,
Enny Kenangalem,
Kim A. Piera,
Anna Ehmann,
Ric N. Price ,
Timothy William,
Tonia Woodberry ,
Simon Foote ,
Gabriela Minigo ,
Tsin W. Yeo ,
Matthew J. Grigg
and other authors.
,
Edison Johar,
Benediktus Andries ,
Jeanne R. Poespoprodjo,
Enny Kenangalem,
Kim A. Piera,
Anna Ehmann,
Ric N. Price ,
Timothy William,
Tonia Woodberry ,
Simon Foote ,
Gabriela Minigo ,
Tsin W. Yeo ,
Matthew J. Grigg
and other authors.
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Abstract
Key Points Platelets directly interact with and kill circulating Plasmodium parasites in patients with malaria to help control parasitemia. In vitro platelet antiplasmodicidal activity against P knowlesi involves platelet–cell binding and intracellular accumulation of PF4.