Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium

Peyrot, Wouter J.; Van der Auwera, Sandra; Milaneschi, Yuri; Dolan, Conor V.; Madden, Pamela A. F.; Sullivan, Patrick F.; Strohmaier, Jana; Ripke, Stephan; Rietschel, Marcella; Nivard, Michel G.; Mullins, Niamh; Montgomery, Grant W.; Henders, Anjali K.; Heat, Andrew C.; Fisher, Helen L.; Dunn, Erin C.; Byrne, Enda M.; Air, Tracy A.; Baune, Bernhard T.; Breen, Gerome; Levinson, Douglas F.; Lewis, Cathryn M.; Martin, Nick G.; Nelson, Elliot N.; Boomsma, Dorret I.; Grabe, Hans J.; Wray, Naomi R.; Penninx, Brenda W. J. H.; Mattheisen, Manuel; Trzaskowski, Maciej; Abdellaoui, Abdel; Adams, Mark J.; Agerbo, Esben; Air, Tracy M.; Andlauer, Till F. M.; Bacanu, Silviu-Alin; Bækvad-Hansen, Marie; Beekman, Aartjan T. F.; Bigdeli, Tim B.; Binder, Elisabeth B.; Blackwood, Douglas H. R.; Bryois, Julien; Buttenschøn, Henriette N.; Bybjerg-Grauholm, Jonas; Cai, Na; Castelao, Enrique; Christensen, Jane Hvarregaard; Clarke, Toni-Kim; Coleman, Jonathan R. I.; Colodro-Conde, Lucía; Couvy-Duchesne, Baptiste; Craddock, Nick; Crawford, Gregory E.; Davies, Gail; Deary, Ian J.; Degenhardt, Franziska; Derks, Eske M.; Direk, Nese; Eley, Thalia C.; Escott-Price, Valentina; Farnush,; Kiadeh, Farhadi Hassan; Finucane, Hilary K.; Forstner, Andreas J.; Frank, Josef; Gaspar, Héléna A.; Gill, Michael; Goes, Fernando S.; Gordon, Scott D.; Grove, Jakob; Hall, Lynsey S.; Hansen, Christine Søholm; Hansen, Thomas F.; Herms, Stefan; Hicki, Ian B.; Hoffmann, Per; Homuth, Georg; Horn, Carsten; Hottenga, Jouke-Jan; Hougaard, David M.; Ising, Marcus; Jansen, Rick; Jorgenson, Eric; Knowles, James A.; Kohane, Isaac S.; Kraft, Julia; Kretzschmar, Warren W.; Krogh, Jesper; Kutalik, Zoltán; Li, Yihan; Lind, Penelope A.; MacIntyre, Donald J.; MacKinnon, Dean F.; Maier, Robert M.; Maier, Wolfgang; Marchini, Jonathan; Mbarek, Hamdi; McGrath, Patrick; McGuffin, Peter; Medland, Sarah E.; Mehta, Divya; Middeldorp, Christel M.; Mihailov, Evelin; Milani, Lili; Mondimore, Francis M.; Mostafavi, Sara; Nauck, Matthias; Ng, Bernard; Nyholt, Dale R.; O’Reilly, Paul F.; Oskarsson, Hogni; Owen, Michael J.; Painter, Jodie N.; Pedersen, Carsten Bøcker; Pedersen, Marianne Giørtz; Peterson, Roseann E.; Pettersson, Erik; Pistis, Giorgio; Posthuma, Danielle; Quiroz, Jorge A.; Qvist, Per; Rice, John P.; Riley, Brien P.; Rivera, Margarita; Mirza, Saira Saeed; Schoevers, Robert; Schulte, Eva C.; Shen, Ling; Shi, Jianxin; Shyn, Stanley I.; Sigurdsson, Engilbert; Sinnamon, Grant C. B.; Smit, Johannes H.; Smith, Daniel J.; Stefansson, Hreinn; Steinberg, Stacy; Streit, Fabian; Tansey, Katherine E.; Teismann, Henning; Teumer, Alexander; Thompson, Wesley; Thomson, Pippa A.; Thorgeirsson, Thorgeir E.; Traylor, Matthew; Treutlein, Jens; Trubetskoy, Vassily; Uitterlinden, André G.; Umbricht, Daniel; van Hemert, Albert M.; Viktorin, Alexander; Visscher, Peter M.; Wang, Yunpeng; Webb, Bradley T.; Weinsheimer, Shantel Marie; Wellmann, Jürgen; Willemsen, Gonneke; Witt, Stephanie H.; Wu, Yang; Xi, Hualin S.; Yang, Jian; Zhang, Futao; Arolt, Volker; Berger, Klaus; Cichon, Sven; Dannlowski, Udo; de Geus, E. J. C.; DePaulo, J. Raymond; Domenici, Enrico; Domschke, Katharina; Esko, Tõnu; Hamilton, Steven P.; Hayward, Caroline; Heath, Andrew C.; Kendler, Kenneth S.; Lewis, Glyn; Kloiber, Stefan; Li, Qingqin S.; Lucae, Susanne; Magnusson, Patrik K.; Martin, Nicholas G.; McIntosh, Andrew M.; Metspalu, Andres; Mors, Ole; Mortensen, Preben Bo; Müller-Myhsok, Bertram; Nordentoft, Merete; Nöthen, Markus M.; O'Donovan, Michael C.; Paciga, Sara A.; Pedersen, Nancy L.; Perlis, Roy H.; Porteous, David J.; Potash, James B.; Preisig, Martin; Schaefer, Catherine; Schulze, Thomas G.; Smoller, Jordan W.; Stefansson, Kari; Tiemeier, Henning; Uher, Rudolf; Völzke, Henry; Weissman, Myrna M.; Werge, Thomas; Børglum, Anders D.

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Tracy M. Air
Peyrot et al., 2018

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Elsevier, Biological Psychiatry, 2(84), p. 138-147, 2018

DOI: 10.1016/j.biopsych.2017.09.009

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@article{Peyrot2018,
  author = {Peyrot, Wouter J. and Van der Auwera, Sandra and Milaneschi, Yuri and Dolan, Conor V. and Madden, Pamela A. F. and Sullivan, Patrick F. and Strohmaier, Jana and Ripke, Stephan and Rietschel, Marcella and Nivard, Michel G. and Mullins, Niamh and Montgomery, Grant W. and Henders, Anjali K. and Heat, Andrew C. and Fisher, Helen L. and Dunn, Erin C. and Byrne, Enda M. and Air, Tracy A. and Baune, Bernhard T. and Breen, Gerome and Levinson, Douglas F. and Lewis, Cathryn M. and Martin, Nick G. and Nelson, Elliot N. and Boomsma, Dorret I. and Grabe, Hans J. and Wray, Naomi R. and Penninx, Brenda W. J. H. and Mattheisen, Manuel and Trzaskowski, Maciej and Abdellaoui, Abdel and Adams, Mark J. and Agerbo, Esben and Air, Tracy M. and Andlauer, Till F. M. and Bacanu, Silviu-Alin and Bækvad-Hansen, Marie and Beekman, Aartjan T. F. and Bigdeli, Tim B. and Binder, Elisabeth B. and Blackwood, Douglas H. R. and Bryois, Julien and Buttenschøn, Henriette N. and Bybjerg-Grauholm, Jonas and Cai, Na and Castelao, Enrique and Christensen, Jane Hvarregaard and Clarke, Toni-Kim and Coleman, Jonathan R. I. and Colodro-Conde, Lucía and Couvy-Duchesne, Baptiste and Craddock, Nick and Crawford, Gregory E. and Davies, Gail and Deary, Ian J. and Degenhardt, Franziska and Derks, Eske M. and Direk, Nese and Eley, Thalia C. and Escott-Price, Valentina and Farnush,  and Kiadeh, Farhadi Hassan and Finucane, Hilary K. and Forstner, Andreas J. and Frank, Josef and Gaspar, Héléna A. and Gill, Michael and Goes, Fernando S. and Gordon, Scott D. and Grove, Jakob and Hall, Lynsey S. and Hansen, Christine Søholm and Hansen, Thomas F. and Herms, Stefan and Hicki, Ian B. and Hoffmann, Per and Homuth, Georg and Horn, Carsten and Hottenga, Jouke-Jan and Hougaard, David M. and Ising, Marcus and Jansen, Rick and Jorgenson, Eric and Knowles, James A. and Kohane, Isaac S. and Kraft, Julia and Kretzschmar, Warren W. and Krogh, Jesper and Kutalik, Zoltán and Li, Yihan and Lind, Penelope A. and MacIntyre, Donald J. and MacKinnon, Dean F. and Maier, Robert M. and Maier, Wolfgang and Marchini, Jonathan and Mbarek, Hamdi and McGrath, Patrick and McGuffin, Peter and Medland, Sarah E. and Mehta, Divya and Middeldorp, Christel M. and Mihailov, Evelin and Milani, Lili and Mondimore, Francis M. and Mostafavi, Sara and Nauck, Matthias and Ng, Bernard and Nyholt, Dale R. and O’Reilly, Paul F. and Oskarsson, Hogni and Owen, Michael J. and Painter, Jodie N. and Pedersen, Carsten Bøcker and Pedersen, Marianne Giørtz and Peterson, Roseann E. and Pettersson, Erik and Pistis, Giorgio and Posthuma, Danielle and Quiroz, Jorge A. and Qvist, Per and Rice, John P. and Riley, Brien P. and Rivera, Margarita and Mirza, Saira Saeed and Schoevers, Robert and Schulte, Eva C. and Shen, Ling and Shi, Jianxin and Shyn, Stanley I. and Sigurdsson, Engilbert and Sinnamon, Grant C. B. and Smit, Johannes H. and Smith, Daniel J. and Stefansson, Hreinn and Steinberg, Stacy and Streit, Fabian and Tansey, Katherine E. and Teismann, Henning and Teumer, Alexander and Thompson, Wesley and Thomson, Pippa A. and Thorgeirsson, Thorgeir E. and Traylor, Matthew and Treutlein, Jens and Trubetskoy, Vassily and Uitterlinden, André G. and Umbricht, Daniel and van Hemert, Albert M. and Viktorin, Alexander and Visscher, Peter M. and Wang, Yunpeng and Webb, Bradley T. and Weinsheimer, Shantel Marie and Wellmann, Jürgen and Willemsen, Gonneke and Witt, Stephanie H. and Wu, Yang and Xi, Hualin S. and Yang, Jian and Zhang, Futao and Arolt, Volker and Berger, Klaus and Cichon, Sven and Dannlowski, Udo and de Geus, E. J. C. and DePaulo, J. Raymond and Domenici, Enrico and Domschke, Katharina and Esko, Tõnu and Hamilton, Steven P. and Hayward, Caroline and Heath, Andrew C. and Kendler, Kenneth S. and Lewis, Glyn and Kloiber, Stefan and Li, Qingqin S. and Lucae, Susanne and Magnusson, Patrik K. and Martin, Nicholas G. and McIntosh, Andrew M. and Metspalu, Andres and Mors, Ole and Mortensen, Preben Bo and Müller-Myhsok, Bertram and Nordentoft, Merete and Nöthen, Markus M. and O'Donovan, Michael C. and Paciga, Sara A. and Pedersen, Nancy L. and Perlis, Roy H. and Porteous, David J. and Potash, James B. and Preisig, Martin and Schaefer, Catherine and Schulze, Thomas G. and Smoller, Jordan W. and Stefansson, Kari and Tiemeier, Henning and Uher, Rudolf and Völzke, Henry and Weissman, Myrna M. and Werge, Thomas and Børglum, Anders D.},
  doi = {10.1016/j.biopsych.2017.09.009},
  journal = {Biological Psychiatry},
  month = {jul},
  pages = {138-147},
  title = {Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium},
  url = {https://oadoi.org/10.1016/j.biopsych.2017.09.009},
  volume = {84},
  year = {2018}
}

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