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American Association for the Advancement of Science, Science Signaling, 251(5), 2012

DOI: 10.1126/scisignal.2003431

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Sumoylation Silences Heterodimeric TASK Potassium Channels Containing K2P1 Subunits in Cerebellar Granule Neurons

Journal article published in 2012 by Leigh D. Plant, Leandro Zuniga, Dan Araki, Jeremy D. Marks ORCID, Steve An N. Goldstein ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The standing outward K+ current (IKso) governs the response of cerebellar granule neurons to natural and medicinal stimuli including volatile anesthetics. In this study, we showed that sumoylation silenced half of IKso at the surface of cerebellar granule neurons because the underlying channels were heterodimeric assemblies of K2P1, a subunit subject to sumoylation, and the two P domain, acid-sensitive K+ (TASK) channel subunits, K2P3 or K2P9. The heteromeric channels comprised the acid-sensitive portion of IKso and mediated its response to halothane. We anticipate that sumoylation also influences sensation and homeostatic mechanisms in mammals through TASK channels formed with K2P1.