American Academy of Neurology (AAN), Neurology, 2(71), p. 129-135, 2008
DOI: 10.1212/01.wnl.0000316802.35974.34
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Background: Multiple sclerosis (MS) has been traditionally considered to be more frequent in women and in regions more distant from the equator. However, recent reports suggest that the latitude gradient could be disappearing and that the female-to-male ratio among patients with MS has increased in the last decades. We have conducted a systematic review of incidence studies of MS to assess the overall incidence of MS and explore possible changes in the latitude gradient and the female-to-male ratio over time.