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Frontiers Media, Frontiers in Genetics, (4)

DOI: 10.3389/fgene.2013.00065

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Genome-Wide Association Study of Personality Traits in the Long Life Family Study

Journal article published in 2013 by Harold T. Bae, Paola Sebastiani, Jenny X. Sun, Stacy L. Andersen ORCID, E. Warwick Daw, Antonio Terracciano, Luigi Ferrucci, Thomas T. Perls
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Personality traits have been shown to be associated with longevity and healthy aging. In order to discover novel genetic modifiers associated with personality traits as related with longevity, we performed a genome-wide association study (GWAS) on personality factors assessed by NEO-five-factor inventory in individuals enrolled in the Long Life Family Study (LLFS), a study of 583 families (N up to 4595) with clustering for longevity in the United States and Denmark. Three SNPs, in almost perfect LD, associated with agreeableness reached genome-wide significance (p