The article addresses the strategic role of workforce preparation in the process of adoption of Systems Medicine as a driver of biomedical research in the new health paradigm. It reports on relevant initiatives, like CASyM, fostering Systems Medicine at EU level. The chapter focuses on the BioHealth Computing Program as a reference for multidisciplinary training of future systems-oriented researchers describing the productive interactions with the Synergy-COPD project. The new paradigm shift in healthcare Discoveries in Health Sciences classically begin at "the bench", with basic research, and then progress to the clini-cal level, or patient's "bedside". Growing barriers and increasing complexities have made difficult to translate new knowledge to the bedside. But, scientists are increas-ingly aware that this "bench-to-bedside" approach shall really be a two-way system providing a fluent and efficient interplay between healthcare and basic biomedical research. The purpose of the manuscript is to pull together the principal findings and recommendations of the various reports and publications concerning the paradigm shift in health taking into account an analysis of the changing nat-ure of the interactions among health practice, research, and education. More specifically, we consider the implica-tions for biomedical innovation from three perspectives: (i) Social context (Section: The social context); (ii) Scienti-fic discipline (Section: Systems Medicine and workforce preparation); and (iii) Educational and training perspective (Section: Systems Medicine post-graduate education: the need for multidisciplinary collaboration). The latter addresses the question of what our global world should seek as objectives of biomedical education and innovation in the 21 st Century, recognizing that these must change significantly to address rapidly changing needs and priorities. Achievement of major breakthroughs in biomedicine depends on rapid adaptation of training schemes and on long-term investment in cutting-edge research. To this end, we analyze the Biohealth Computing program for Master and PhD students, as an example of educational and training program aiming to produce translational researchers aligned with the new health paradigm. Finally we suggest a roadmap to the future: a series of recommendations and actions aimed at transforming practice, research, and education, with the fundamental objective of sustaining and enhancing our capacity for biomedical innovation which constitutes a key element for economic prosperity and social well-being. Systems thinking approach is not new to biomedicine, having been historically applied in the physiological sciences. However, it had to be abandoned because of the lack of necessary data and tools. Today, the revolutions in molecular biology and in Information and Communication Technologies (ICT) constitute key enablers to re-assess old problems under the new health paradigm.