@article{Bodden2017, abstract = {AbstractBoth negative and positive social experiences during sensitive life phases profoundly shape brain and behaviour. Current research is therefore increasingly focusing on mechanisms mediating the interaction between varying life experiences and the epigenome. Here, male mice grew up under either adverse or beneficial conditions until adulthood, when they were subdivided into groups exposed to situations that either matched or mismatched previous conditions. It was investigated whether the resulting four life histories were associated with changes in anxiety-like behaviour, gene expression of selected genes involved in anxiety and stress circuits, and arginine vasopressin receptor 1a (Avpr1a) gene methylation. Varying experiences during life significantly modulated (1) anxiety-like behaviour; (2) hippocampal gene expression of Avpr1a, serotonin receptor 1a (Htr1a), monoamine oxidase A (Maoa), myelin basic protein (Mbp), glucocorticoid receptor (Nr3c1), growth hormone (Gh); and (3) hippocampal DNA methylation within the Avpr1a gene. Notably, mice experiencing early beneficial and later adverse conditions showed a most pronounced downregulation of Avpr1a expression, accompanied by low anxiety-like behaviour. This decrease in Avpr1a expression may have been, in part, a consequence of increased methylation in the Avpr1a gene. In summary, this study highlights the impact of interactive social experiences throughout life on the hippocampal epigenotype and associated behaviour.}, author = {Bodden, Carina and van den Hove, Daniel and Lesch, Klaus-Peter and Sachser, Norbert}, doi = {10.1038/s41598-017-09292-0}, journal = {Scientific Reports}, month = {aug}, title = {Impact of varying social experiences during life history on behaviour, gene expression, and vasopressin receptor gene methylation in mice}, url = {https://doi.org/10.1038/s41598-017-09292-0}, volume = {7}, year = {2017} } @article{Demontis2016, author = {Demontis, Ditte and Lescai, Francesco and Børglum, Anders and Glerup, Simon and Østergaard, Søren Dinesen and Mors, Ole and Li, Qibin and Liang, Jieqin and Jiang, Hui and Li, Yingrui and Wang, Jun and Lesch, Klaus-Peter and Reif, Andreas and Buitelaar, Jan K. and Franke, Barbara}, doi = {10.1016/j.jaac.2016.03.009}, journal = {Journal of the American Academy of Child and Adolescent Psychiatry}, month = {jun}, pages = {521-523}, title = {Whole-Exome Sequencing Reveals Increased Burden of Rare Functional and Disruptive Variants in Candidate Risk Genes in Individuals With Persistent Attention-Deficit/Hyperactivity Disorder}, url = {https://oadoi.org/10.1016/j.jaac.2016.03.009}, volume = {55}, year = {2016} } @article{Enge2016, abstract = {Several studies reported training-induced improvements in executive function tasks and also observed transfer to untrained tasks. However, the results are mixed and there is large interindividual variability within and across studies. Given that training-related performance changes would require modification, growth or differentiation at the cellular and synaptic level in the brain, research on critical moderators of brain plasticity potentially explaining such changes is needed. In the present study, a pre-post-follow-up design (N=122) and a three-weeks training of two response inhibition tasks (Go/NoGo and Stop-Signal) was employed and genetic variation (Val66Met) in the brain-derived neurotrophic factor (BDNF) promoting differentiation and activity-dependent synaptic plasticity was examined. Because Serotonin (5-HT) signaling and the interplay of BDNF and 5-HT are known to critically mediate brain plasticity, genetic variation in the 5-HT transporter (5-HTTLPR) was also addressed. The overall results show that the kind of training (i.e., adaptive vs. non-adaptive) did not evoke genotype-dependent differences. However, in the Go/NoGo task, better inhibition performance (lower commission errors) were observed for BDNF Val/Val genotype carriers compared to Met-allele ones supporting similar findings from other cognitive tasks. Additionally, a gene-gene interaction suggests a more impulsive response pattern (faster responses accompanied by higher commission error rates) in homozygous l-allele carriers relative to those with the s-allele of 5-HTTLPR. This, however, is true only in the presence of the Met-allele of BDNF, while the Val/Val genotype seems to compensate for such non-adaptive responding. Intriguingly, similar results were obtained for the Stop-Signal task. Here, differences emerged at post-testing, while no differences were observed at T1. In sum, although no genotype-dependent differences between the relevant training groups emerged suggesting no changes in the trained inhibition function, the observed genotype-dependent performance changes from pre- to post measurement may reflect rapid learning or memory effects linked to BDNF and 5-HTTLPR. In line with ample evidence on BDNF and BDNF-5-HT system interactions to induce (rapid) plasticity especially in hippocampal regions and in response to environmental demands, the findings may reflect genotype-dependent differences in the acquisition and consolidation of task-relevant information, thereby facilitating a more adaptive responding to task-specific requirements.}, author = {Enge, Sören and Fleischhauer, Monika and Gaertner, Anne and Gärtner, Anne and Reif, Andreas and Lesch, Klaus-Peter and Kliegel, Matthias and Strobel, Alexander}, doi = {10.3389/fnhum.2016.00370}, journal = {Frontiers in Human Neuroscience}, month = {jul}, title = {Brain-derived neurotrophic factor (Val66Met) and serotonin transporter (5-HTTLPR) polymorphisms modulate plasticity in inhibitory control performance over time but independent of inhibitory control training}, url = {https://doi.org/10.3389/fnhum.2016.00370}, volume = {10}, year = {2016} } @article{Fischer2017, author = {Fischer, Matthias and Cabello, Victoria and Popp, Sandy and Krackow, Sven and Hommers, Leif and Deckert, Jürgen and Lesch, Klaus-Peter and Schmitt-Böhrer, Angelika G.}, doi = {10.1007/s10519-017-9853-3}, journal = {Behavior Genetics}, month = {jun}, pages = {434-448}, title = { Rsk2 Knockout Affects Emotional Behavior in the IntelliCage}, url = {https://oadoi.org/10.1007/s10519-017-9853-3}, volume = {47}, year = {2017} } @article{Frey2016, author = {Frey, Anna and Saxon, Veronica-Maria and Popp, Sandy and Lehmann, Marc and Mathes, Denise and Pachel, Christina and Hofmann, Ulrich and Ertl, Georg and Lesch, Klaus-Peter and Frantz, Stefan}, doi = {10.1016/j.yjmcc.2016.07.002}, journal = {Journal of Molecular and Cellular Cardiology}, month = {sep}, pages = {28-36}, title = {Early citalopram treatment increases mortality due to left ventricular rupture in mice after myocardial infarction}, url = {https://oadoi.org/10.1016/j.yjmcc.2016.07.002}, volume = {98}, year = {2016} } @article{Gruenewald2016, abstract = {The DIRAS2 gene is coding for a small Ras GTPase with so far unknown function. In a previous study, we described the association of DIRAS2 rs1412005, as well as a haplotype containing this polymorphism and located in the promoter region of this gene with attentiondeficit/hyperactivity disorder (ADHD). In the present study, we searched for rare variants within or near the DIRAS2 gene that might be associated with ADHD using next-generation sequencing. As we were not able to detect any rare variants associated with the disease, we sought to establish a functional role of DIRAS2 rs1412005 on the molecular or systems level. First, we investigated whether it has an influence on gene expression by means of a luciferase-based promoter assay. We could demonstrate that the minor risk allele goes along with the increased expression of the reporter gene. Next, we aimed to identify differences in response inhibition between risk-allele and non-risk allele carriers in children suffering from ADHD and healthy control individuals by analyzing event-related potentials in the electroencephalogram during a Go/NoGo task. Risk-allele carriers showed a changed NoGo anteriorization. Therefore, our results suggest an impact of the investigated polymorphism on the prefrontal response control in children with ADHD. These results imply that the promoter polymorphism is indeed the associated as well as in itself a causal variant. Further research is thus warranted to clarify the mechanisms linking DIRAS2 to ADHD.}, author = {Gruenewald, L. and Grünewald, Lena and Landaas, Elisabeth Toverud and Geissler, Julia and Weber, Heike and Quast, Carina and Röh, Simone and Schartner, Christoph and Lesch, Klaus-Peter and Romanos, Marcel and Kittel-Schneider, Sarah and Binder, Elisabeth and Reif, Andreas}, doi = {10.1038/npp.2016.113}, journal = {Neuropsychopharmacology}, month = {jul}, pages = {3025-3031}, title = {Functional Impact of An ADHD-Associated DIRAS2 Promoter Polymorphism}, url = {http://europepmc.org/articles/pmc5101550?pdf=render}, volume = {41}, year = {2016} } @article{Hoogman2017, author = {Hoogman, Martine and Bralten, Janita and Hibar, Derrek P. and Mennes, Maarten and Zwiers, Marcel P. and Schweren, Lizanne S. J. and van Hulzen, Kimm J. E. and Medland, Sarah E. and Shumskaya, Elena and Jahanshad, Neda and Zeeuw, Patrick de and Szekely, Eszter and Sudre, Gustavo and Wolfers, Thomas and Onnink, Alberdingk M. H. and Dammers, Janneke T. and Mostert, Jeanette C. and Vives-Gilabert, Yolanda and Kohls, Gregor and Oberwelland, Eileen and Seitz, Jochen and Schulte-Rüther, Martin and Ambrosino, Sara and Doyle, Alysa E. and Høvik, Marie F. and Dramsdahl, Margaretha and Tamm, Leanne and van Erp, Theo G. M. and Dale, Anders and Schork, Andrew and Conzelmann, Annette and Zierhut, Kathrin and Baur, Ramona and McCarthy, Hazel and Yoncheva, Yuliya N. and Cubillo, Ana and Chantiluke, Kaylita and Mehta, Mitul A. and Paloyelis, Yannis and Hohmann, Sarah and Baumeister, Sarah and Bramati, Ivanei and Mattos, Paulo and Tovar-Moll, Fernanda and Douglas, Pamela and Banaschewski, Tobias and Brandeis, Daniel and Kuntsi, Jonna and Asherson, Philip and Rubia, Katya and Kelly, Clare and Martino, Adriana Di and Milham, Michael P. and Castellanos, Francisco X. and Frodl, Thomas and Zentis, Mariam and Lesch, Klaus-Peter and Reif, Andreas and Pauli, Paul and Jernigan, Terry L. and Haavik, Jan and Plessen, Kerstin J. and Lundervold, Astri J. and Hugdahl, Kenneth and Seidman, Larry J. and Biederman, Joseph and Rommelse, Nanda and Heslenfeld, Dirk J. and Hartman, Catharina A. and Hoekstra, Pieter J. and Oosterlaan, Jaap and Polier, Georg von and Konrad, Kerstin and Vilarroya, Oscar and Ramos-Quiroga, Josep Antoni and Soliva, Joan Carles and Durston, Sarah and Buitelaar, Jan K. and Faraone, Stephen V. and Shaw, Philip and Thompson, Paul M. and Franke, Barbara}, doi = {10.1016/s2215-0366(17)30049-4}, journal = {The Lancet Psychiatry}, month = {apr}, pages = {310-319}, title = {Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis}, url = {https://oadoi.org/10.1016/s2215-0366(17)30049-4}, volume = {4}, year = {2017} } @article{Klein2016, author = {Klein, Marieke and Berger, Stefanie and Hoogman, Martine and Dammers, Janneke and Makkinje, Remco and Heister, Angelien J. G. A. M. and Galesloot, Tessel E. and Kiemeney, Lambertus A. L. M. and Weber, Heike and Kittel-Schneider, Sarah and Lesch, Klaus-Peter and Reif, Andreas and Ribasés, Marta and Ramos-Quiroga, Josep Antoni and Cormand, Bru and Zayats, Tetyana and Hegvik, Tor-Arne and Jacobsen, Kaya K. and Johansson, Stefan and Haavik, Jan and Mota, Nina R. and Bau, Claiton H. D. and Grevet, Eugenio H. and Doyle, Alysa and Faraone, Stephen V. and Arias-Vásquez, Alejandro and Franke, Barbara}, doi = {10.1016/j.euroneuro.2016.06.012}, journal = {European Neuropsychopharmacology}, month = {sep}, pages = {1527-1532}, title = {Meta-analysis of the DRD5 VNTR in persistent ADHD}, url = {https://oadoi.org/10.1016/j.euroneuro.2016.06.012}, volume = {26}, year = {2016} } @article{Kyriakakis2017, author = {Kyriakakis, Emmanouil and Frismantiene, Agne and Dasen, Boris and Pfaff, Dennis and Rivero, Olga and Lesch, Klaus-Peter and Erne, Paul and Resink, Therese J. and Philippova, Maria}, doi = {10.1016/j.cellsig.2017.04.004}, journal = {Cellular Signalling}, month = {jul}, pages = {163-175}, title = {T-cadherin promotes autophagy and survival in vascular smooth muscle cells through MEK1/2/Erk1/2 axis activation}, url = {https://oadoi.org/10.1016/j.cellsig.2017.04.004}, volume = {35}, year = {2017} } @article{Lesch2016, author = {Lesch, Klaus-Peter}, doi = {10.1111/jcpp.12574}, journal = {Journal of Child Psychology and Psychiatry}, month = {may}, pages = {659-661}, title = {Maturing insights into the genetic architecture of neurodevelopmental disorders - from common and rare variant interplay to precision psychiatry}, url = {http://onlinelibrary.wiley.com/doi/10.1111/jcpp.12574/pdf}, volume = {57}, year = {2016} } @article{Merker2017, author = {Merker, Sören and Reif, Andreas and Ziegler, Georg C. and Weber, Heike and Mayer, Ute and Ehlis, Ann-Christine and Conzelmann, Annette and Johansson, Stefan and Müller-Reible, Clemens and Nanda, Indrajit and Haaf, Thomas and Ullmann, Reinhard and Romanos, Marcel and Fallgatter, Andreas J. and Pauli, Paul and Strekalova, Tatyana and Jansch, Charline and Vasquez, Alejandro Arias and Haavik, Jan and Ribasés, Marta and Ramos-Quiroga, Josep Antoni and Buitelaar, Jan K. and Franke, Barbara and Lesch, Klaus-Peter}, doi = {10.1111/jcpp.12702}, journal = {Journal of Child Psychology and Psychiatry}, month = {feb}, pages = {798-809}, title = { SLC2A3 single-nucleotide polymorphism and duplication influence cognitive processing and population-specific risk for attention-deficit/hyperactivity disorder}, url = {https://oadoi.org/10.1111/jcpp.12702}, volume = {58}, year = {2017} } @article{Meyer2016, author = {Meyer, Neele and Richter, S. Helene and Schreiber, Rebecca S. and Kloke, Vanessa and Kaiser, Sylvia and Lesch, Klaus-Peter and Sachser, Norbert}, doi = {10.3389/fnbeh.2016.00097}, journal = {Frontiers in Behavioral Neuroscience}, month = {may}, title = {The Unexpected Effects of Beneficial and Adverse Social Experiences during Adolescence on Anxiety and Aggression and Their Modulation by Genotype}, url = {https://doi.org/10.3389/fnbeh.2016.00097}, volume = {10}, year = {2016} } @incollection{Norton2017, author = {Norton, William and Lange, Merlin and Bally-Cuif, Laure and Lesch, Klaus-Peter}, doi = {10.1007/978-3-319-33774-6_7}, journal = {The rights and wrongs of zebrafish: Behavioral phenotyping of zebrafish}, month = {jan}, pages = {145-169}, title = {Zebrafish Models of Attention-Deficit/Hyperactivity Disorder (ADHD)}, url = {https://oadoi.org/10.1007/978-3-319-33774-6_7}, year = {2017} } @article{Prelog2016, author = {Prelog, Martina and Hilligardt, Deborah and Schmidt, Christian A. and Przybylski, Grzegorz K. and Leierer, Johannes and Almanzar, Giovanni and El Hajj, Nady and Lesch, Klaus-Peter and Arolt, Volker and Zwanzger, Peter and Haaf, Thomas and Domschke, Katharina}, doi = {10.1371/journal.pone.0157930}, journal = {PLoS ONE}, month = {jun}, pages = {e0157930}, title = {Hypermethylation of FOXP3 Promoter and Premature Aging of the Immune System in Female Patients with Panic Disorder?}, url = {https://doi.org/10.1371/journal.pone.0157930}, volume = {11}, year = {2016} } @article{Reuter2016, author = {Reuter, Isabel and Knaup, Sabine and Romanos, Marcel and Lesch, Klaus-Peter and Drepper, Carsten and Lillesaar, Christina}, doi = {10.1007/s00702-016-1556-z}, journal = {Journal of Neural Transmission}, month = {apr}, pages = {841-848}, title = {Developmental exposure to acetaminophen does not induce hyperactivity in zebrafish larvae}, url = {https://oadoi.org/10.1007/s00702-016-1556-z}, volume = {123}, year = {2016} } @article{Strekalova2017, author = {Strekalova, Tatyana and Bahzenova, Nataliia and Trofimov, Alexander and Schmitt-Böhrer, Angelika G. and Markova, Nataliia and Grigoriev, Vladimir and Zamoyski, Vladimir and Serkova, Tatiana and Redkozubova, Olga and Vinogradova, Daria and Umriukhin, Alexei and Fisenko, Vladimir and Lillesaar, Christina and Shevtsova, Elena and Sokolov, Vladimir and Aksinenko, Alexey and Lesch, Klaus-Peter and Bachurin, Sergey}, doi = {10.1007/s12035-017-0745-6}, journal = {Molecular Neurobiology}, month = {aug}, pages = {335-349}, title = {Pro-neurogenic, Memory-Enhancing and Anti-stress Effects of DF302, a Novel Fluorine Gamma-Carboline Derivative with Multi-target Mechanism of Action}, url = {https://oadoi.org/10.1007/s12035-017-0745-6}, volume = {55}, year = {2017} } @article{Trofimov2017, author = {Trofimov, Alexander and Strekalova, Tatyana and Mortimer, Niall and Zubareva, Olga and Schwarz, Alexander and Svirin, Evgeniy and Umriukhin, Aleksei and Svistunov, Andrei and Lesch, Klaus-Peter and Klimenko, Victor}, doi = {10.1007/s12640-017-9720-2}, journal = {Neurotoxicity Research}, month = {apr}, pages = {175-186}, title = {Postnatal LPS Challenge Impacts Escape Learning and Expression of Plasticity Factors Mmp9 and Timp1 in Rats: Effects of Repeated Training}, url = {http://link.springer.com/content/pdf/10.1007/s12640-017-9720-2.pdf}, volume = {32}, year = {2017} } @article{van Hulzen2016, author = {van Hulzen, Kimm J. E. and Franke, Barbara and Scholz, Claus-Jürgen and Ripke, Stephan and Klein, Marieke and McQuillin, Andrew and Sonuga-Barke, Edmund J. and Kelsoe, John R. and Landén, Mikael and Andreassen, Ole A. and Lesch, Klaus-Peter and Weber, Heike and Faraone, Stephen V. and Arias-Vasquez, Alejandro and Reif, Andreas}, doi = {10.1016/j.biopsych.2016.08.040}, journal = {Biological Psychiatry}, month = {oct}, title = {Genetic Overlap Between Attention-Deficit/Hyperactivity Disorder and Bipolar Disorder: Evidence From Genome-wide Association Study Meta-analysis.}, url = {http://eprints.soton.ac.uk/399606/}, year = {2016} } @article{Veniaminova2016, author = {Veniaminova, Ekaterina and Cespuglio, Raymond and Markova, Nataliia and Mortimer, Niall and Cheung, Chi Wai and Steinbusch, Harry W. and Lesch, Klaus-Peter and Strekalova, Tatyana}, doi = {10.18679/cn11-6030_r.2016.014}, journal = {Translational Neuroscience and Clinics}, month = {jun}, pages = {87-95}, title = {Behavioral Features of Mice Fed with a Cholesterol-Enriched Diet: Deficient Novelty Exploration and Unaltered Aggressive Behavior}, url = {https://oadoi.org/10.18679/cn11-6030_r.2016.014}, volume = {2}, year = {2016} } @article{Veniaminova2017, author = {Veniaminova, Ekaterina and Cespuglio, Raymond and Cheung, Chi Wai and Umriukhin, Alexei and Markova, Nataliia and Shevtsova, Elena and Lesch, Klaus-Peter and Anthony, Daniel C. and Strekalova, Tatyana}, doi = {10.1155/2017/9498247}, journal = {Neural Plasticity}, month = {jan}, pages = {1-14}, title = {Autism-Like Behaviours and Memory Deficits Result from a Western Diet in Mice}, url = {https://doi.org/10.1155/2017/9498247}, volume = {2017}, year = {2017} }