@article{Armbruster2020, author = {Armbruster, Diana and Brocke, Burkhard and Kirschbaum, Clemens and Witt, Stephanie H. and Lesch, Klaus-Peter and Strobel, Alexander}, doi = {10.1016/j.physbeh.2020.112831}, journal = {Physiology & Behavior}, month = {may}, pages = {112831}, title = {Rhythm and blues: Influence of CLOCK T3111C on peripheral electrophysiological indicators of negative affective processing}, url = {https://oadoi.org/10.1016/j.physbeh.2020.112831}, volume = {219}, year = {2020} } @article{Enge2019, abstract = {AbstractFunctional genetic polymorphisms in the brain dopamine (DA) system have been suggested to underlie individual differences in response inhibition, namely the suppression of a prepotent or inappropriate action. However, findings on associations between single DA polymorphisms and inhibitory control often are mixed, partly due to their small effect sizes. In the present study, a cumulative genetic score (CGS) was used: alleles previously associated with both impulsive behavior and lower baseline DA level, precisely the DRD4 Exon III 7-repeat, DAT1 VNTR 10-repeat and the COMT 158val allele, each added a point to the DA-CGS. Participants (N = 128) completed a Go/No-Go task varying in difficulty and EEG recordings were made with focus on the NoGo-P3, an ERP that reflects inhibitory response processes. We found a higher DA-CGS (lower basal/tonic DA level) to be associated with better performance (lower %FA and more adaptive responding) in the very demanding/rapid than in the less demanding/rapid condition, whereas the reverse pattern was true for individuals with a lower DA-CGS. A similar interaction pattern of DA-CGS and task condition was found for NoGo-P3 amplitude. In line with assumptions of distinct optimum DA levels for different cognitive demands, a DA-CGS-dependent variation of tonic DA levels could have modulated the balance between cognitive stability and flexibility, thereby affecting the optimal DA level required for the specific task condition. Moreover, a task demand-dependent phasic DA release might have added to the DA-CGS-related basal/tonic DA levels, thereby additionally affecting the balance between flexibility and stability, in turn influencing performance and NoGo-P3.}, author = {Enge, Sören and Sach, Mareike and Reif, Andreas and Lesch, Klaus-Peter and Miller, Robert and Fleischhauer, Monika}, doi = {10.3758/s13415-019-00752-w}, journal = {Cognitive, Affective, and Behavioral Neuroscience}, month = {dec}, pages = {59-75}, title = {Cumulative Dopamine Genetic Score predicts behavioral and electrophysiological correlates of response inhibition via interactions with task demand}, url = {https://oadoi.org/10.3758/s13415-019-00752-w}, volume = {20}, year = {2019} } @article{Forero2020, author = {Forero, Andrea and Ku, Hsing-Ping and Malpartida, Ana Belén and Wäldchen, Sina and Alhama-Riba, Judit and Kulka, Christina and Aboagye, Benjamin and Norton, William H. J. and Young, Andrew M. J. and Ding, Yu-Qiang and Blum, Robert and Sauer, Markus and Rivero, Olga and Lesch, Klaus-Peter}, doi = {10.1016/j.neuropharm.2020.108018}, journal = {Neuropharmacology}, month = {may}, pages = {108018}, title = {Serotonin (5-HT) neuron-specific inactivation of Cadherin-13 impacts 5-HT system formation and cognitive function}, url = {https://oadoi.org/10.1016/j.neuropharm.2020.108018}, volume = {168}, year = {2020} } @article{Gorlova2020, author = {Gorlova, Anna and Ortega, Gabriela and Waider, Jonas and Bazhenova, Natalia and Veniaminova, Ekaterina and Proshin, Andrey and Kalueff, Allan V. and Anthony, Daniel C. and Lesch, Klaus-Peter and Strekalova, Tatyana}, doi = {10.1016/j.jad.2020.04.014}, journal = {Journal of Affective Disorders}, month = {jul}, pages = {440-451}, title = {Stress-induced aggression in heterozygous TPH2 mutant mice is associated with alterations in serotonin turnover and expression of 5-HT6 and AMPA subunit 2A receptors}, url = {https://oadoi.org/10.1016/j.jad.2020.04.014}, volume = {272}, year = {2020} } @article{Hoogman2020, author = {Hoogman, Martine and van Rooij, Daan and Rooij, Daan and Klein, Marieke and Boedhoe, Premika and Ilioska, Iva and Li, Ting and Patel, Yash and Postema, Merel C. and Zhang‐James, Yanli and Anagnostou, Evdokia and Arango, Celso and Auzias, Guillaume and Banaschewski, Tobias and Bau, Claiton H. D. and Behrmann, Marlene and Bellgrove, Mark A. and Brandeis, Daniel and Brem, Silvia and Busatto, Geraldo F. and Calderoni, Sara and Calvo, Rosa and Castellanos, Francisco X. and Coghill, David and Conzelmann, Annette and Daly, Eileen and Deruelle, Christine and Dinstein, Ilan and Durston, Sarah and Ecker, Christine and Ehrlich, Stefan and Epstein, Jeffery N. and Fair, Damien A. and Fitzgerald, Jacqueline and Freitag, Christine M. and Frodl, Thomas and Gallagher, Louise and Grevet, Eugenio H. and Haavik, Jan and Hoekstra, Pieter J. and Janssen, Joost and Karkashadze, Georgii and King, Joseph A. and Konrad, Kerstin and Kuntsi, Jonna and Lazaro, Luisa and Lerch, Jason P. and Lesch, Klaus‐Peter and Louza, Mario R. and Luna, Beatriz and Mattos, Paulo and McGrath, Jane and Muratori, Filippo and Murphy, Clodagh and Nigg, Joel T. and Oberwelland‐Weiss, Eileen and O'Gorman Tuura, Ruth L. and O'Hearn, Kirsten and Oosterlaan, Jaap and Parellada, Mara and Pauli, Paul and Plessen, Kerstin J. and Ramos‐Quiroga, J. Antoni and Reif, Andreas and Reneman, Liesbeth and Retico, Alessandra and Rosa, Pedro G. P. and Rubia, Katya and Shaw, Philip and Silk, Tim J. and Tamm, Leanne and Vilarroya, Oscar and Walitza, Susanne and Jahanshad, Neda and van den Heuvel, Odile A. and Faraone, Stephen V. and Francks, Clyde and Heuvel, Odile A. and Paus, Tomas and Thompson, Paul M. and Buitelaar, Jan K. and Franke, Barbara}, doi = {10.1002/hbm.25029}, journal = {Human Brain Mapping}, month = {may}, pages = {37-55}, title = {Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure}, url = {https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhbm.25029}, volume = {43}, year = {2020} } @article{Kappel2019, author = {Kappel, Djenifer B. and Maceda, Iago and Børglum, Anders and Lesch, Klaus-Peter and Reif, Andreas and Cormand, Bru and Demontis, Ditte and Bau, Claiton H. D. and Lao, Oscar}, doi = {10.1016/j.euroneuro.2019.07.218}, journal = {European Neuropsychopharmacology}, month = {oct}, pages = {S103}, title = {77 Insights From Rare Variants Into Adhd Symptoms in a Clinical Setting and the General Population}, url = {https://oadoi.org/10.1016/j.euroneuro.2019.07.218}, volume = {29}, year = {2019} } @article{Lee2019, author = {Lee, Phil H. and Won, Hyejung and Rosenthal, Jacob and Zhu, Zhaozhong and Tucker-Drob, Elliot M. and Posthuma, Danielle and Wang, Meg M.-J. and Yu, Dongmei and Stahl, Eli A. and Walters, Raymond K. and Rohde, Luis A. and Zai, Clement C. and Poterba, Timothy and Poulsen, Jesper B. and Ramos-Quiroga, Josep Antoni and Reif, Andreas and Ribasés, Marta and Rothenberger, Aribert and Rovira, Paula and Sánchez-Mora, Cristina and Satterstrom, F. Kyle and Schachar, Russell and Steinberg, Stacy and Stefansson, Hreinn and Turley, Patrick and Walters, G. Bragi and Werge, Thomas and Zayats, Tetyana and Qvist, Per and Rehnström, Karola and Reichenberg, Abraham and Reichert, Jennifer and Roeder, Kathryn and Rouleau, Guy A. and Saemundsen, Evald and Sanders, Stephan J. and Sandin, Sven and St Pourcain, Beate and Stefansson, Kari and Sutcliffe, James S. and Talkowski, Michael E. and Anttila, Verneri and Weiss, Lauren A. and Willsey, A. Jeremy and Feng, Yen-Chen A. and Nivard, Michel G. and Grotzinger, Andrew D. and Anney, Richard J. L. and Duncan, Laramie E. and Ge, Tian and Adolfsson, Rolf and Banaschewski, Tobias and Belangero, Sintia and Cook, Edwin H. and Coppola, Giovanni and Derks, Eske M. and Hoekstra, Pieter J. and Kaprio, Jaakko and Keski-Rahkonen, Anna and Kirov, George and Kranzler, Henry R. and Luykx, Jurjen J. and Agerbo, Esben and Arranz, M. J. and Asherson, Philip and Bækvad-Hansen, Marie and Baldursson, Gísli and Bellgrove, Mark and Belliveau, Richard A. and Buitelaar, Jan and Burton, Christie L. and Bybjerg-Grauholm, Jonas and Casas, Miquel and Cerrato, Felecia and Chambert, Kimberly and Churchhouse, Claire and Cormand, Bru and Crosbie, Jennifer and Dalsgaard, Søren and Demontis, Ditte and Doyle, Alysa E. and Dumont, Ashley and Elia, Josephine and Grove, Jakob and Gudmundsson, Olafur O. and Haavik, Jan and Hakonarson, Hakon and Hansen, Christine S. and Hartman, Catharina A. and Hawi, Ziarih and Potash, James B. and Hervás, Amaia and Reinbold, Céline S. and Hougaard, David M. and Rietschel, Marcella and Howrigan, Daniel P. and Rivera, Margarita and Huang, Hailiang and Roberson, Mary and Kuntsi, Jonna and Schalling, Martin and Langley, Kate and Schofield, Peter R. and Lesch, Klaus-Peter and Schulze, Thomas G. and Leung, Patrick W. L. and Scott, Laura J. and Loo, Sandra K. and Serretti, Alessandro and Martin, Joanna and Sigurdsson, Engilbert and Martin, Alicia R. and Smeland, Olav B. and McGough, James J. and Stordal, Eystein and Medland, Sarah E. and Streit, Fabian and Moran, Jennifer L. and Strohmaier, Jana and Mors, Ole and Thorgeirsson, Thorgeir E. and Mortensen, Preben B. and Treutlein, Jens and Oades, Robert D. and Turecki, Gustavo and Palmer, Duncan S. and Vaaler, Arne E. and Pedersen, Carsten B. and Vieta, Eduard and Pedersen, Marianne G. and Vincent, John B. and Peters, Triinu and Wang, Yunpeng and Witt, Stephanie H. and Zandi, Peter and Artigas, Maria Soler and Arking, Dan E. and Bettella, Francesco and Buxbaum, Joseph D. and Christensen, Jane H. and Collins, Ryan L. and Coon, Hilary and De Rubeis, Silvia and Delorme, Richard and Grice, Dorothy E. and Hansen, Thomas F. and Holmans, Peter A. and Hope, Sigrun and Hultman, Christina M. and Klei, Lambertus and Ladd-Acosta, Christine and Magnusson, Pall and Nærland, Terje and Nyegaard, Mette and Pinto, Dalila and Agartz, Ingrid and Akil, Huda and Albani, Diego and Alda, Martin and Als, Thomas D. and Anjorin, Adebayo and Backlund, Lena and Rabionet, Raquel and Bass, Nicholas and Raevuori, Anu and Bauer, Michael and Ramoz, Nicolas and Baune, Bernhard T. and Reichborn-Kjennerud, Ted and Bellivier, Frank and Ricca, Valdo and Bergen, Sarah E. and Roberts, Marion and Berrettini, Wade H. and Rujescu, Dan and Biernacka, Joanna M. and Rybakowski, Filip and Blackwood, Douglas H. R. and Scherag, André and Bøen, Erlend and Schmidt, Ulrike and Budde, Monika and Seitz, Jochen and Bunney, William and Slachtova, Lenka and Burmeister, Margit and Slof-Op‘t Landt, Margarita C. T. and Byerley, William and Slopien, Agnieszka and Byrne, Enda M. and Sorbi, Sandro and Cichon, Sven and Southam, Lorraine and Clarke, Toni-Kim and Strober, Michael and Coleman, Jonathan R. I. and Tortorella, Alfonso and Craddock, Nicholas and Tozzi, Federica and Curtis, David and Treasure, Janet and Czerski, Piotr M. and Tziouvas, Konstantinos and Dale, Anders M. and van Elburg, Annemarie A. and Dalkner, Nina and Wade, Tracey D. and Dannlowski, Udo and Wagner, Gudrun and Degenhardt, Franziska and Walton, Esther and Di Florio, Arianna and Watson, Hunna J. and Elvsåshagen, Torbjørn and Wichmann, H.-Erich and Etain, Bruno and Woodside, D. Blake and Fischer, Sascha B. and Zeggini, Eleftheria and Forstner, Andreas J. and Zerwas, Stephanie and Forty, Liz and Zipfel, Stephan and Frank, Josef and Frye, Mark and Fullerton, Janice M. and Gade, Katrin and Gaspar, Héléna A. and Gershon, Elliot S. and Gill, Michael and Goes, Fernando S. and Gordon, Scott D. and Gordon-Smith, Katherine and Green, Melissa J. and Greenwood, Tiffany A. and Grigoroiu-Serbanescu, Maria and Guzman-Parra, José and Hauser, Joanna and Hautzinger, Martin and Heilbronner, Urs and Porteous, David J. and Herms, Stefan and Preisig, Martin and Hoffmann, Per and Quiroz, Jorge A. and Holland, Dominic and Schaefer, Catherine and Jamain, Stéphane and Schulte, Eva C. and Jones, Ian and Shi, Jianxin and Jones, Lisa A. and Smith, Daniel J. and Kandaswamy, Radhika and Thomson, Pippa A. and Kelsoe, John R. and Tiemeier, Henning and Kennedy, James L. and Uher, Rudolf and Joachim, Oedegaard Ketil and van der Auwera, Sandra and Kittel-Schneider, Sarah and Weissman, Myrna M. and Kogevinas, Manolis and Koller, Anna C. and Lavebratt, Catharina and Lewis, Cathryn M. and Li, Qingqin S. and Lissowska, Jolanta and Loohuis, Loes M. O. and Lucae, Susanne and Maaser, Anna and Malt, Ulrik F. and Martin, Nicholas G. and Martinsson, Lina and McElroy, Susan L. and McMahon, Francis J. and McQuillin, Andrew and Melle, Ingrid and Metspalu, Andres and Millischer, Vincent and Mitchell, Philip B. and Montgomery, Grant W. and Morken, Gunnar and Morris, Derek W. and Müller-Myhsok, Bertram and Mullins, Niamh and Pulver, Ann E. and Myers, Richard M. and Quested, Digby J. and Nievergelt, Caroline M. and Riley, Brien and Nordentoft, Merete and Sanders, Alan R. and Adolfsson, Annelie Nordin and Schall, Ulrich and Nöthen, Markus M. and Schwab, Sibylle G. and Ophoff, Roel A. and Scott, Rodney J. and Owen, Michael J. and Sham, Pak C. and Paciga, Sara A. and Silverman, Jeremy M. and Pato, Carlos N. and Sim, Kang and Pato, Michele T. and Steixner, Agnes A. and Perlis, Roy H. and Tooney, Paul A. and Perry, Amy and van Os, Jim and Vawter, Marquis P. and Walsh, Dermot and Weiser, Mark and Wildenauer, Dieter B. and Williams, Nigel M. and Wormley, Brandon K. and Zhang, Fuquan and Adan, Roger A. H. and Alfredsson, Lars and Ando, Tetsuya and Aschauer, Harald and Baker, Jessica H. and Bencko, Vladimir and Bergen, Andrew W. and Kim, Youl-Ri and Birgegård, Andreas and Perica, Vesna Boraska and Brandt, Harry and Burghardt, Roland and Carlberg, Laura and Cassina, Matteo and Clementi, Maurizio and Courtet, Philippe and Crawford, Steven and Crow, Scott and Crowley, James J. and Danner, Unna N. and Davis, Oliver S. P. and Degortes, Daniela and DeSocio, Janiece E. and Dick, Danielle M. and Dina, Christian and Docampo, Elisa and Egberts, Karin and Ehrlich, Stefan and Espeseth, Thomas and Fernández-Aranda, Fernando and Fichter, Manfred M. and Foretova, Lenka and Plessen, Kerstin J. and Forzan, Monica and Richter, Margaret A. and Gambaro, Giovanni and Rizzo, Renata and Giegling, Ina and Robertson, Mary and Gonidakis, Fragiskos and Roessner, Veit and Gorwood, Philip and Ruhrmann, Stephan and Mayora, Monica Gratacos and Samuels, Jack F. and Guo, Yiran and Sandor, Paul and Halmi, Katherine A. and Schlögelhofer, Monika and Hatzikotoulas, Konstantinos and Shin, Eun-Young and Hebebrand, Johannes and Singer, Harvey and Helder, Sietske G. and Song, Dong-Ho and Herpertz-Dahlmann, Beate and Song, Jungeun and Herzog, Wolfgang and Spalletta, Gianfranco and Hinney, Anke and Stein, Dan J. and Imgart, Hartmut and Stewart, S. Evelyn and Jiménez-Murcia, Susana and Storch, Eric A. and Johnson, Craig and Stranger, Barbara and Stuhrmann, Manfred and Jordan, Jennifer and Tarnok, Zsanett and Julià, Antonio and Tischfield, Jay A. and Kaminská, Deborah and Tübing, Jennifer and Karhunen, Leila and Visscher, Frank and Karwautz, Andreas and Vulink, Nienke and Kas, Martien J. H. and Wagner, Michael and Kaye, Walter H. and Walitza, Susanne and Kennedy, Martin A. and Wanderer, Sina and Woods, Martin and Klareskog, Lars and Worbe, Yulia and Klump, Kelly L. and Zai, Gwyneth and Knudsen, Gun Peggy S. and Zinner, Samuel H. and Landén, Mikael and Sullivan, Patrick F. and Le Hellard, Stephanie and Levitan, Robert D. and Li, Dong and Lichtenstein, Paul and Zheutlin, Amanda and Maj, Mario and Marsal, Sara and McDevitt, Sara and Mitchell, James and Monteleone, Palmiero and Monteleone, Alessio Maria and Munn-Chernoff, Melissa A. and Ripke, Stephan and Nacmias, Benedetta and Santangelo, Susan L. and Navratilova, Marie and Scharf, Jeremiah M. and Stein, Murray B. and O’Toole, Julie K. and Thornton, Laura M. and Padyukov, Leonid and Walters, James T. R. and Pantel, Jacques and Wray, Naomi R. and Papezova, Hana and Lewis, Glyn and Smoller, Jordan W. and Adams, Mark J. and Andlauer, Till F. M. and Berger, Klaus and Binder, Elisabeth B. and Plee0@mgh Harvard Edu, Cross-Disorder Group of the Psychiatric Genomics Consortium Electronic address: and Boomsma, Dorret I. and Castelao, Enrique and Colodro-Conde, Lucía and Direk, Nese and Docherty, Anna R. and Domenici, Enrico and Domschke, Katharina and Dunn, Erin C. and Foo, Jerome C. and Kim, Y.-R. and D.-E. Geus, E. J. C. and Grabe, Hans J. and Hamilton, Steven P. and Horn, Carsten and Hottenga, Jouke-Jan and Howard, David and Ising, Marcus and Kloiber, Stefan and Levinson, Douglas F. and M., Maj and Magnusson, Patrik K. E. and Mbarek, Hamdi and Middeldorp, Christel M. and Mostafavi, Sara and Nyholt, Dale R. and Penninx, Brenda W.-J.-H. and Peterson, Roseann E. and Pistis, Giorgio and O'Toole, J. K. and Alexander, Madeline and Begemann, Martin and Bramon, Elvira and Buccola, Nancy G. and Cairns, Murray J. and Campion, Dominique and Carr, Vaughan J. and Cloninger, C. Robert and Cohen, David and Collier, David A. and Corvin, Aiden and DeLisi, Lynn E. and Donohoe, Gary and Dudbridge, Frank and Duan, Jubao and Freedman, Robert and Gejman, Pablo V. and Golimbet, Vera and Godard, Stephanie and Ehrenreich, Hannelore and Hartmann, Annette M. and Henskens, Frans A. and Ikeda, Masashi and Iwata, Nakao and Jablensky, Assen V. and Joa, Inge and Jönsson, Erik G. and Kelly, Brian J. and Knight, Jo and Konte, Bettina and Laurent-Levinson, Claudine and Lee, Jimmy and Lencz, Todd and Lerer, Bernard and Loughland, Carmel M. and Malhotra, Anil K. and Mallet, Jacques and McDonald, Colm and Mitjans, Marina and Mowry, Bryan J. and Murphy, Kieran C. and Murray, Robin M. and O’Neill, F. Anthony and Oh, Sang-Yun and Palotie, Aarno and Pantelis, Christos and Petryshen, Tracey L. and Androutsos, Christos and Arnold, Paul D. and Barr, Cathy L. and Barta, Csaba and Bey, Katharina and Bienvenu, O. Joseph and Black, Donald W. and Brown, Lawrence W. and Budman, Cathy and Cath, Danielle and Cheon, Keun-Ah and Ciullo, Valentina and Coffey, Barbara J. and Cusi, Daniele and Davis, Lea K. and O'Neill, F. A. and Denys, Damiaan and Depienne, Christel and Dietrich, Andrea and Eapen, Valsamma and Kim, Young Key and Falkai, Peter and Kim, Young-Shin and Fernandez, Thomas V. and Garcia-Delgar, Blanca and Geller, Daniel A. and Gilbert, Donald L. and Grados, Marco A. and Greenberg, Erica and Grünblatt, Edna and Hagstrøm, Julie and Hanna, Gregory L. and Hartmann, Andreas and Hedderly, Tammy and Heiman, Gary A. and Heyman, Isobel and Hong, Hyun Ju and Huang, Alden and Huyser, Chaim and Ibanez-Gomez, Laura and Khramtsova, Ekaterina A. and King, Robert A. and Koh, Yun-Joo and Konstantinidis, Anastasios and Kook, Sodahm and Kuperman, Samuel and Leventhal, Bennett L. and Lochner, Christine and Ludolph, Andrea G. and Madruga-Garrido, Marcos and Malaty, Irene and Maras, Athanasios and McCracken, James T. and Meijer, Inge A. and Mir, Pablo and Morer, Astrid and Müller-Vahl, Kirsten R. and Münchau, Alexander and Murphy, Tara L. and Kim, Y. K. and Naarden, Allan and Nagy, Peter and Nestadt, Gerald and Nestadt, Paul S. and Nicolini, Humberto and Nurmi, Erika L. and Okun, Michael S. and Paschou, Peristera and Piras, Fabrizio and Piras, Federica and Pittenger, Christopher and Franke, Barbara and Daly, Mark J. and Bulik, Cynthia M. and McIntosh, Andrew M. and O’Donovan, Michael C. and Andreassen, Ole A. and Børglum, Anders D. and O'Donovan, M. C. and Breen, Gerome and Edenberg, Howard J. and Fanous, Ayman H. and Faraone, Stephen V. and Gelernter, Joel and Mathews, Carol A. and Mattheisen, Manuel and Mitchell, Karen S. and Neale, Michael C. and Nurnberger, John I. and Geschwind, Daniel H. and Neale, Benjamin M. and Kendler, Kenneth S. and Consortium, Cross-Disorder Group of the Psychiatric Genomics}, doi = {10.1016/j.cell.2019.11.020}, journal = {Cell}, month = {dec}, pages = {1469-1482.e11}, title = {Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders}, url = {https://oadoi.org/10.1016/j.cell.2019.11.020}, volume = {179}, year = {2019} } @article{Lieb2019, author = {Lieb, Margaret W. and Arnold, Mathew R. and Loupy, Kelsey M. and Nguyen, Kadi T. and Hassell, James E. and Schnabel, K’Loni S. and Weidner, Magdalena and Kern, Raphael and Day, Heidi E. W. and Lesch, Klaus-Peter and Waider, Jonas and Lowry, Christopher A.}, doi = {10.1016/j.bbr.2019.112086}, journal = {Behavioural Brain Research}, month = {nov}, pages = {112086}, title = {Effects of maternal separation on serotonergic systems in the dorsal and median raphe nuclei of adult male Tph2-deficient mice}, url = {https://oadoi.org/10.1016/j.bbr.2019.112086}, volume = {373}, year = {2019} } @article{McNeill2020, abstract = {AbstractGenetic and molecular mechanisms that play a causal role in mental illnesses are challenging to elucidate, particularly as there is a lack of relevant in vitro and in vivo models. However, the advent of induced pluripotent stem cell (iPSC) technology has provided researchers with a novel toolbox. We conducted a systematic review using the PRISMA statement. A PubMed and Web of Science online search was performed (studies published between 2006–2020) using the following search strategy: hiPSC OR iPSC OR iPS OR stem cells AND schizophrenia disorder OR personality disorder OR antisocial personality disorder OR psychopathy OR bipolar disorder OR major depressive disorder OR obsessive compulsive disorder OR anxiety disorder OR substance use disorder OR alcohol use disorder OR nicotine use disorder OR opioid use disorder OR eating disorder OR anorexia nervosa OR attention-deficit/hyperactivity disorder OR gaming disorder. Using the above search criteria, a total of 3515 studies were found. After screening, a final total of 56 studies were deemed eligible for inclusion in our study. Using iPSC technology, psychiatric disease can be studied in the context of a patient’s own unique genetic background. This has allowed great strides to be made into uncovering the etiology of psychiatric disease, as well as providing a unique paradigm for drug testing. However, there is a lack of data for certain psychiatric disorders and several limitations to present iPSC-based studies, leading us to discuss how this field may progress in the next years to increase its utility in the battle to understand psychiatric disease.}, author = {McNeill, Rhiannon V. and Ziegler, Georg C. and Radtke, Franziska and Nieberler, Matthias and Lesch, Klaus-Peter and Kittel-Schneider, Sarah}, doi = {10.1007/s00702-020-02197-9}, journal = {Journal of Neural Transmission}, month = {may}, pages = {1547-1568}, title = {Mental health dished up—the use of iPSC models in neuropsychiatric research}, url = {https://oadoi.org/10.1007/s00702-020-02197-9}, volume = {127}, year = {2020} } @article{Munter2019, author = {Munter, Johannes P. J. M. and Shafarevich, Igor and Liundup, Alexei and Pavlov, Dmitrii and Wolters, Erik Ch and Gorlova, Anna and Veniaminova, Ekaterina and Umriukhin, Aleksei and Kalueff, Allan and Svistunov, Andrei and Kramer, Boris W. and Lesch, Klaus‐Peter and Strekalova, Tatyana}, doi = {10.1111/cns.13280}, journal = {CNS Neuroscience and Therapeutics}, month = {dec}, pages = {504-517}, title = {Neuro‐Cells therapy improves motor outcomes and suppresses inflammation during experimental syndrome of amyotrophic lateral sclerosis in mice}, url = {https://doi.org/10.1111/cns.13280}, volume = {26}, year = {2019} } @article{Munter2020, author = {Munter, Johannes P. J. M. and Shafarevich, Igor and Liundup, Alexei and Pavlov, Dmitrii and Wolters, Erik Ch and Gorlova, Anna and Veniaminova, Ekaterina and Umriukhin, Aleksei and Kalueff, Allan and Svistunov, Andrei and Kramer, Boris W. and Lesch, Klaus‐Peter and Strekalova, Tatyana}, doi = {10.1111/cns.13161}, journal = {CNS Neuroscience and Therapeutics}, month = {apr}, title = {Inside Front Cover}, url = {https://doi.org/10.1111/cns.13161}, volume = {26}, year = {2020} } @article{Munter2020_2, author = {Munter, Johannes and Babaevskaya, Diana and Wolters, Erik C.-H. and Pavlov, Dmitrii and Lysikova, Ekaterina and Kalueff, Allan and Gorlova, Anna and Oplatchikova, Margarita and Pomytkin, Igor A. and Proshin, Andrey and Umriukhin, Aleksei and Lesch, Klaus‐Peter and Strekalova, Tatyana}, doi = {10.1111/jcmm.15628}, journal = {Journal of Cellular and Molecular Medicine}, month = {jul}, pages = {10251-10257}, title = {Molecular and behavioural abnormalities in the FUS‐tg mice mimic frontotemporal lobar degeneration: Effects of old and new anti‐inflammatory therapies}, url = {https://doi.org/10.1111/jcmm.15628}, volume = {24}, year = {2020} } @article{Rovira2020, author = {Rovira, Paula and da Silva, Bruna Santos and Zayats, Tetyana and Demontis, Ditte and , and Sánchez-Mora, Cristina and Weber, Heike and Klein, Marieke and Mota, Nina Roth and Garcia-Martínez, Iris and Pagerols, Mireia and Arribas, Lorena and Richarte, Vanesa and Corrales, Montserrat and Fadeuilhe, Christian and Bosch, Rosa and Martin, Gemma Español and Almos, Peter and Doyle, Alysa E. and Grevet, Eugenio Horacio and Grimm, Oliver and Vilar Ribó, Laura and Halmøy, Anne and Hoogman, Martine and Hutz, Mara and Jacob, Christian P. and Kittel-Schneider, Sarah and Knappskog, Per M. and Lundervold, Astri J. and Rivero, Olga and Rovaris, Diego Luiz and Salatino-Oliveira, Angelica and Silva, B. S. D. and Svirin, Evgeniy and Sprooten, Emma and Strekalova, Tatyana and Arias-Vasquez, Alejandro and Sonuga Barke, Edmund J. S. and Asherson, Philip and Dotto Bau, C. H. and Bau, Claiton Henrique Dotto and Buitelaar, Jan K. and Cormand, Bru and Faraone, Stephen V. and Haavik, Jan and Johansson, Stefan E. and Kuntsi, Jonna and Larsson, Henrik and Lesch, Klaus-Peter and Reif, Andreas and Rohde, Luis Augusto and Casas, Miquel and Børglum, Anders D. and Franke, Barbara and Ramos-Quiroga, Josep Antoni and Artigas, María Soler and And, Marta Ribasés and Ribasés, M.}, month = {apr}, title = {Shared genetic background between children and adults with attention deficit/hyperactivity disorder}, year = {2020} } @article{Schiele2019, author = {Schiele, Miriam A. and Kollert, Leonie and Lesch, Klaus-Peter and Arolt, Volker and Zwanzger, Peter and Deckert, Jürgen and Ziegler, Christiane and Domschke, Katharina}, doi = {10.1016/j.euroneuro.2019.07.131}, journal = {European Neuropsychopharmacology}, month = {oct}, pages = {1161-1167}, title = {Hypermethylation of the serotonin transporter gene promoter in panic disorder–Epigenetic imprint of comorbid depression?}, url = {https://oadoi.org/10.1016/j.euroneuro.2019.07.131}, volume = {29}, year = {2019} } @article{Schneider2020, abstract = {AbstractMemory decline can be a devastating disease and increases in aging Western populations. Memory enhancement technologies hold promise for this and other conditions. Approaches include stem cell transplantation, which improved memory in several animal studies as well as vaccination against Alzheimer´s disease (AD) by β-amyloid antibodies. For a positive clinical effect, the vaccine should probably be administered over a long period of time and before amyloid pathologies manifest in the brain. Different drugs, such as erythropoietin or antiplatelet therapy, improve memory in neuropsychiatric diseases or AD or at least in animal studies. Omega-3 polyunsaturated fatty acid-rich diets improve memory through the gut–brain axis by altering the gut flora through probiotics. Sports, dancing, and memory techniques (e.g., Method of Loci) utilize behavioral approaches for memory enhancement, and were effective in several studies. Augmented reality (AR) is an auspicious way for enhancing memory in real time. Future approaches may include memory prosthesis for head-injured patients and light therapy for restoring memory in AD. Memory enhancement in humans in health and disease holds big promises for the future. Memory training helps only in mild or no impairment. Clinical application requires further investigation.}, author = {Schneider, Felicitas and Horowitz, Alan and Lesch, Klaus-Peter and Dandekar, Thomas}, doi = {10.1038/s41398-020-0697-x}, journal = {Translational Psychiatry}, month = {jan}, title = {Delaying memory decline: different options and emerging solutions}, url = {https://oadoi.org/10.1038/s41398-020-0697-x}, volume = {10}, year = {2020} } @article{Stegner2019, abstract = { Background and Purpose— Ischemic stroke is one of the leading causes of disability and death. The principal goal of acute stroke treatment is the recanalization of the occluded cerebral arteries, which is, however, only effective in a very narrow time window. Therefore, neuroprotective treatments that can be combined with recanalization strategies are needed. Calcium overload is one of the major triggers of neuronal cell death. We have previously shown that capacitative Ca 2+ entry, which is triggered by the depletion of intracellular calcium stores, contributes to ischemia-induced calcium influx in neurons, but the responsible Ca 2+ channel is not known. Methods— Here, we have generated mice lacking the calcium channel subunit Orai2 and analyzed them in experimental stroke. Results— Orai2-deficient mice were protected from ischemic neuronal death both during acute ischemia under vessel occlusion and during ischemia/reperfusion upon successful recanalization. Calcium signals induced by calcium store depletion or oxygen/glucose deprivation were significantly diminished in Orai2-deficient neurons demonstrating that Orai2 is a central mediator of neuronal capacitative Ca 2+ entry and is involved in calcium overload during ischemia. Conclusions— Our experimental data identify Orai2 as an attractive target for pharmaceutical intervention in acute stroke. }, author = {Stegner, David and Hofmann, Sebastian and Schuhmann, Michael K. and Kraft, Peter and Herrmann, Alexander M. and Popp, Sandy and Höhn, Marlen and Popp, Michael and Klaus, Vanessa and Post, Antonia and Kleinschnitz, Christoph and Braun, Attila and Meuth, Sven G. and Lesch, Klaus-Peter and Stoll, Guido and Kraft, Robert and Nieswandt, Bernhard}, doi = {10.1161/strokeaha.119.025357}, journal = {Stroke}, month = {nov}, pages = {3238-3245}, title = {Loss of Orai2-Mediated Capacitative Ca 2+ Entry Is Neuroprotective in Acute Ischemic Stroke}, url = {https://oadoi.org/10.1161/strokeaha.119.025357}, volume = {50}, year = {2019} } @article{Veniaminova2020, author = {Veniaminova, Ekaterina and Oplatchikova, Margarita and Bettendorff, Lucien and Kotenkova, Elena and Lysko, Alexander and Vasilevskaya, Ekaterina and Kalueff, Allan V. and Fedulova, Liliya and Umriukhin, Aleksei and Lesch, Klaus-Peter and Anthony, Daniel C. and Strekalova, Tatyana}, doi = {10.1016/j.lfs.2019.117163}, journal = {Life Sciences}, month = {jan}, pages = {117163}, title = {Prefrontal cortex inflammation and liver pathologies accompany cognitive and motor deficits following Western diet consumption in non-obese female mice}, url = {https://oadoi.org/10.1016/j.lfs.2019.117163}, volume = {241}, year = {2020} } @article{Veniaminova2020_2, author = {Veniaminova, Ekaterina and Cespuglio, Raymond and Chernukha, Irina and Schmitt-Boehrer, Angelika G. and Morozov, Sergey and Kalueff, Allan V. and Kuznetsova, Oxana and Anthony, Daniel C. and Lesch, Klaus-Peter and Strekalova, Tatyana}, doi = {10.3389/fnins.2020.00024}, journal = {Frontiers in Neuroscience}, month = {feb}, title = {Metabolic, Molecular, and Behavioral Effects of Western Diet in Serotonin Transporter-Deficient Mice: Rescue by Heterozygosity?}, url = {https://doi.org/10.3389/fnins.2020.00024}, volume = {14}, year = {2020} } @article{Ziegler2019, abstract = {AbstractIn panic disorder (PD), epigenetic mechanisms such as DNA methylation of candidate genes have been suggested to play a key role at the intersection of genetic and environmental factors. On an epigenome-wide level, however, only two studies in PD patients have been published so far, while to date no study has intra-individually analyzed dynamic epigenetic correlates of treatment-response in PD on a DNA methylome level. Here, an epigenome-wide association study (EWAS) was performed in a sample of 57 PD patients and matched healthy controls using the Illumina MethylationEPIC BeadChip, along with a longitudinal approach assessing changes on the DNA methylome level corresponding to clinical effects of a manualized six-week cognitive-behavioral therapy (CBT) in PD. While no epigenome-wide significant hits could be discerned, top suggestive evidence was observed for decreased methylation in PD at cg19917903 in the Cilia and Flagella Associated Protein 46 (CFAP46) gene, and for an increase in methylation after CBT at cg06943668 in the Interleukin 1 Receptor Type 1 (IL1R1) gene in treatment responders to CBT. Additional exploratory analyses based on biological validity and a combined statistical/biological ranking point to further new potential PD risk genes such as the CCL4L1 or GMNN genes, and suggest dynamic methylation of, e.g., the ZFP622 and the SLC43A2 genes along with response to CBT. These EWAS and first longitudinal epigenome-wide pilot data in PD add to the emerging candidate gene-based body of evidence for epigenetic mechanisms to be involved in PD pathogenesis and to possibly constitute dynamic biological correlates of therapeutic interventions.}, author = {Ziegler, Christiane and Grundner-Culemann, Franziska and Ma, Schiele and Schiele, Miriam A. and Schlosser, Pascal and Kollert, Leonie and Mahr, Marina and Gajewska, Agnieszka and Kp, Lesch and Lesch, Klaus-Peter and Deckert, Jürgen and Köttgen, Anna and Domschke, Katharina}, doi = {10.1038/s41398-019-0648-6}, journal = {Translational Psychiatry}, month = {nov}, title = {The DNA methylome in panic disorder: a case-control and longitudinal psychotherapy-epigenetic study}, url = {https://doi.org/10.1038/s41398-019-0648-6}, volume = {9}, year = {2019} } @article{Ziegler2020, author = {Ziegler, Georg C. and Almos, Peter and McNeill, Rhiannon V. and Jansch, Charline and Lesch, Klaus‐Peter}, doi = {10.1002/jcp.29753}, journal = {Journal of Cellular Physiology}, month = {may}, pages = {9021-9036}, title = {Cellular effects and clinical implications of SLC2A3 copy number variation}, url = {https://oadoi.org/10.1002/jcp.29753}, volume = {235}, year = {2020} }