@article{Akhrif2021, author = {Akhrif, Atae and Roy, Arunima and Peters, Katharina and Lesch, Klaus‐Peter and Romanos, Marcel and Schmitt‐Böhrer, Angelika and Neufang, Susanne}, doi = {10.1002/brb3.2054}, journal = {Brain and Behavior}, month = {feb}, title = {REVERSE phenotyping—Can the phenotype following constitutive Tph2 gene inactivation in mice be transferred to children and adolescents with and without adhd?}, url = {https://doi.org/10.1002/brb3.2054}, volume = {11}, year = {2021} } @article{Cabana-Domínguez2023, author = {Cabana-Domínguez, Judit and Antón-Galindo, Ester and Fernàndez-Castillo, Noèlia and Singgih, Euginia L. and O’Leary, Aet and Norton, William Hg and Strekalova, Tatyana and Schenck, Annette and Reif, Andreas and Lesch, Klaus-Peter and Slattery, David and Cormand, Bru}, doi = {10.1016/j.neubiorev.2022.104949}, journal = {Neuroscience & Biobehavioral Reviews}, month = {jan}, pages = {104949}, title = {The translational genetics of ADHD and related phenotypes in model organisms}, url = {https://oadoi.org/10.1016/j.neubiorev.2022.104949}, volume = {144}, year = {2023} } @article{Cupaioli2020, author = {Cupaioli, Francesca A. and Zucca, Fabio A. and Caporale, Cinzia and Lesch, Klaus-Peter and Passamonti, Luca and Zecca, Luigi}, doi = {10.1016/j.pnpbp.2020.110059}, journal = {Progress in Neuro-Psychopharmacology and Biological Psychiatry}, month = {aug}, pages = {110059}, title = {The neurobiology of human aggressive behavior: Neuroimaging, genetic, and neurochemical aspects}, url = {https://oadoi.org/10.1016/j.pnpbp.2020.110059}, volume = {106}, year = {2020} } @article{Demontis2023, author = {Demontis, Ditte and Bragi Walters, G. and Walters, G. Bragi and Athanasiadis, Georgios and Walters, Raymond and Therrien, Karen and Nielsen, Trine Tollerup and Farajzadeh, Leila and Voloudakis, Georgios and Bendl, Jaroslav and Zeng, Biau and Zhang, Wen and Grove, Jakob and Als, Thomas D. and Duan, Jinjie and Kyle Satterstrom, F. and Satterstrom, F. Kyle and Bybjerg-Grauholm, Jonas and Bækved-Hansen, Marie and Gudmundsson, Olafur O. and Magnusson, Sigurdur H. and Baldursson, Gisli and Davidsdottir, Katrin and Haraldsdottir, Gyda S. and Agerbo, Esben and Hoffman, Gabriel E. and Dalsgaard, Søren and Martin, Jonna and Ribasés, Marta and Boomsma, Dorret I. and Artigas, Maria Soler and Soler Artigas, Maria and Mota, Nina Roth and Roth Mota, Nina and Howrigan, Daniel and Medland, Sarah E. and Zayats, Tetyana and Rajagopal, Veera M. and Havdahl, Alexandra and Doyle, Alysa and Reif, Andreas and Thapar, Anita and Cormand, Bru and Liao, Calwing and Burton, Christie and Bau, Claiton H. D. and Rovaris, Diego Luiz and Sonuga-Barke, Edmund and Corfield, Elizabeth and Grevet, Eugenio Horacio and Larsson, Henrik and Gizer, Ian R. and Waldman, Irwin and Brikell, Isabell and Haavik, Jan and Crosbie, Jennifer and McGough, James and Kuntsi, Jonna and Glessner, Joseph and Langley, Kate and Lesch, Klaus-Peter and Rohde, Luis Augusto and Hutz, Mara H. and Klein, Marieke and Bellgrove, Mark and Tesli, Martin and O’Donovan, Michael C. and Andreassen, Ole Andreas and Leung, Patrick W. L. and Pan, Pedro M. and Joober, Ridha and Schachar, Russel and Loo, Sandra and Witt, Stephanie H. and Reichborn-Kjennerud, Ted and Banaschewski, Tobias and Hawi, Ziarih and Daly, Mark J. and Mors, Ole and Nordentoft, Merete and Hougaard, David M. and Mortensen, Preben Bo and Faraone, Stephen V. and Stefansson, Hreinn and Roussos, Panos and Franke, Barbara and Werge, Thomas and Neale, Benjamin M. and Stefansson, Kari and Børglum, Anders D.}, doi = {10.1038/s41588-023-01350-w}, journal = {Nature Genetics}, month = {apr}, title = {Author Correction: Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains}, url = {https://www.nature.com/articles/s41588-023-01350-w.pdf}, year = {2023} } @article{Grimm2020, abstract = {While impulsivity is a basic feature of attention-deficit/hyperactivity disorder (ADHD), no study explored the effect of different components of the Impulsiveness (Imp) and Venturesomeness (Vent) scale (IV7) on psychiatric comorbidities and an ADHD polygenic risk score (PRS). We used the IV7 self-report scale in an adult ADHD sample of 903 patients, 70% suffering from additional comorbid disorders, and in a subsample of 435 genotyped patients. Venturesomeness, unlike immediate Impulsivity, is not specific to ADHD. We consequently analyzed the influence of Imp and Vent also in the context of a PRS on psychiatric comorbidities of ADHD. Vent shows a distinctly different distribution of comorbidities, e.g., less anxiety and depression. PRS showed no effect on different ADHD comorbidities, but correlated with childhood hyperactivity. In a complementary analysis using principal component analysis with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition ADHD criteria, revised NEO Personality Inventory, Imp, Vent, and PRS, we identified three ADHD subtypes. These are an impulsive–neurotic type, an adventurous–hyperactive type with a stronger genetic component, and an anxious–inattentive type. Our study thus suggests the importance of adventurousness and the differential consideration of impulsivity in ADHD. The genetic risk is distributed differently between these subtypes, which underlines the importance of clinically motivated subtyping. Impulsivity subtyping might give insights into the organization of comorbid disorders in ADHD and different genetic background.}, author = {Grimm, Oliver and Weber, Heike and Kittel-Schneider, Sarah and Kranz, Thorsten M. and Jacob, Christian P. and Lesch, Klaus-Peter and Reif, Andreas}, doi = {10.3389/fpsyt.2020.557160}, journal = {Frontiers in Psychiatry}, month = {dec}, title = {Impulsivity and Venturesomeness in an Adult ADHD Sample: Relation to Personality, Comorbidity, and Polygenic Risk}, url = {https://doi.org/10.3389/fpsyt.2020.557160}, volume = {11}, year = {2020} } @article{Homberg2021, author = {Homberg, Judith R. and Adan, Roger A. H. and Alenina, Natalia and Asiminas, Antonis and Bader, Michael and Beckers, Tom and Begg, Denovan P. and Blokland, Arjan and Burger, Marilise E. and van Dijk, Gertjan and Eisel, Ulrich L. M. and Elgersma, Ype and Englitz, Bernhard and Fernandez-Ruiz, Antonio and Fitzsimons, Carlos P. and van Dam, Anne-Marie and Gass, Peter and Grandjean, Joanes and Havekes, Robbert and Henckens, Marloes J. A. G. and Herden, Christiane and Hut, Roelof A. and Jarrett, Wendy and Jeffrey, Kate and Jezova, Daniela and Kalsbeek, Andries and Kamermans, Maarten and Kas, Martien J. and Kasri, Nael Nadif and Kiliaan, Amanda J. and Kolk, Sharon M. and Korosi, Aniko and Korte, S. Mechiel and Kozicz, Tamas and Kushner, Steven A. and Leech, Kirk and Lesch, Klaus-Peter and Lesscher, Heidi and Lucassen, Paul J. and Luthi, Anita and Ma, Liya and Mallien, Anne S. and Meerlo, Peter and Mejias, Jorge F. and Meye, Frank J. and Mitchell, Anna S. and Mul, Joram D. and Olcese, Umberto and González, Azahara Oliva and Olivier, Jocelien D. A. and Pasqualetti, Massimo and Pennartz, Cyriel M. A. and Popik, Piotr and Prickaerts, Jos and de la Prida, Liset M. and Ribeiro, Sidarta and Roozendaal, Benno and Rossato, Janine I. and Salari, Ali-Akbar and Schoemaker, Regien G. and Smit, August B. and Vanderschuren, Louk J. M. J. and Takeuchi, Tomonori and van der Veen, Rixt and Smidt, Marten P. and Vyazovskiy, Vladyslav V. and Wiesmann, Maximilian and Wierenga, Corette J. and Williams, Bella and Willuhn, Ingo and Wöhr, Markus and Wolvekamp, Monique and van der Zee, Eddy A. and Genzel, Lisa}, doi = {10.1016/j.neuron.2021.07.015}, journal = {Neuron}, month = {aug}, pages = {2374-2379}, title = {The continued need for animals to advance brain research}, url = {https://oadoi.org/10.1016/j.neuron.2021.07.015}, volume = {109}, year = {2021} } @article{Jansch2021, abstract = {AbstractHuman induced pluripotent stem cells (hiPSCs) have revolutionized the generation of experimental disease models, but the development of protocols for the differentiation of functionally active neuronal subtypes with defined specification is still in its infancy. While dysfunction of the brain serotonin (5-HT) system has been implicated in the etiology of various neuropsychiatric disorders, investigation of functional human 5-HT specific neurons in vitro has been restricted by technical limitations. We describe an efficient generation of functionally active neurons from hiPSCs displaying 5-HT specification by modification of a previously reported protocol. Furthermore, 5-HT specific neurons were characterized using high-end fluorescence imaging including super-resolution microscopy in combination with electrophysiological techniques. Differentiated hiPSCs synthesize 5-HT, express specific markers, such as tryptophan hydroxylase 2 and 5-HT transporter, and exhibit an electrophysiological signature characteristic of serotonergic neurons, with spontaneous rhythmic activities, broad action potentials and large afterhyperpolarization potentials. 5-HT specific neurons form synapses reflected by the expression of pre- and postsynaptic proteins, such as Bassoon and Homer. The distribution pattern of Bassoon, a marker of the active zone along the soma and extensions of neurons, indicates functionality via volume transmission. Among the high percentage of 5-HT specific neurons (~ 42%), a subpopulation of CDH13 + cells presumably designates dorsal raphe neurons. hiPSC-derived 5-HT specific neuronal cell cultures reflect the heterogeneous nature of dorsal and median raphe nuclei and may facilitate examining the association of serotonergic neuron subpopulations with neuropsychiatric disorders.}, author = {Jansch, Charline and Ziegler, Georg C. and Forero, Andrea and Gredy, Sina and Wäldchen, Sina and Vitale, Maria Rosaria and Svirin, Evgeniy and Zöller, Johanna E. M. and Waider, Jonas and Günther, Katharina and Edenhofer, Frank and Sauer, Markus and Wischmeyer, Erhard and Lesch, Klaus-Peter}, doi = {10.1007/s00702-021-02303-5}, journal = {Journal of Neural Transmission}, month = {feb}, pages = {225-241}, title = {Serotonin-specific neurons differentiated from human iPSCs form distinct subtypes with synaptic protein assembly}, url = {https://oadoi.org/10.1007/s00702-021-02303-5}, volume = {128}, year = {2021} } @article{Kolter2021, abstract = {The serotonin transporter (5-HTT) is a key molecule of serotoninergic neurotransmission and target of many anxiolytics and antidepressants. In humans, 5-HTT gene variants resulting in lower expression levels are associated with behavioral traits of anxiety. Furthermore, functional magnetic resonance imaging (fMRI) studies reported increased cerebral blood flow (CBF) during resting state (RS) and amygdala hyperreactivity. 5-HTT deficient mice as an established animal model for anxiety disorders seem to be well suited for investigating amygdala (re-)activity in an fMRI study. We investigated wildtype (5-HTT+/+), heterozygous (5-HTT+/-), and homozygous 5-HTT-knockout mice (5-HTT-/-) of both sexes in an ultra-high-field 17.6 Tesla magnetic resonance scanner. CBF was measured with continuous arterial spin labeling during RS, stimulation state (SS; with odor of rats as aversive stimulus), and post-stimulation state (PS). Subsequently, post mortem c-Fos immunohistochemistry elucidated neural activation on cellular level. The results showed that in reaction to the aversive odor CBF in total brain and amygdala of all mice significantly increased. In male 5-HTT+/+ mice amygdala RS CBF levels were found to be significantly lower than in 5-HTT+/- mice. From RS to SS 5-HTT+/+ amygdala perfusion significantly increased compared to both 5-HTT+/- and 5-HTT-/- mice. Perfusion level changes of male mice correlated with the density of c-Fos-immunoreactive cells in the amygdaloid nuclei. In female mice the perfusion was not modulated by the 5-Htt-genotype, but by estrous cycle stages. We conclude that amygdala reactivity is modulated by the 5-Htt genotype in males. In females, gonadal hormones have an impact which might have obscured genotype effects. Furthermore, our results demonstrate experimental support for the tonic model of 5-HTTLPR function.}, author = {Kolter, Jann F. and Hildenbrand, Markus F. and Popp, Sandy and Nauroth, Stephan and Bankmann, Julian and Rother, Lisa and Waider, Jonas and Deckert, Jürgen and Asan, Esther and Jakob, Peter M. and Lesch, Klaus-Peter and Schmitt-Böhrer, Angelika}, doi = {10.1371/journal.pone.0247311}, journal = {PLoS ONE}, month = {feb}, pages = {e0247311}, title = {Serotonin transporter genotype modulates resting state and predator stress-induced amygdala perfusion in mice in a sex-dependent manner}, url = {https://doi.org/10.1371/journal.pone.0247311}, volume = {16}, year = {2021} } @article{Leibold2020, abstract = {Background: Inhaling 35% carbon dioxide induces an emotional and symptomatic state in humans closely resembling naturally occurring panic attacks, the core symptom of panic disorder. Previous research has suggested a role of the serotonin system in the individual sensitivity to carbon dioxide. In line with this, we previously showed that a variant in the SLC6A4 gene, encoding the serotonin transporter, moderates the fear response to carbon dioxide in humans. To study the etiological basis of carbon dioxide-reactivity and panic attacks in more detail, we recently established a translational mouse model. Aim: The purpose of this study was to investigate whether decreased expression of the serotonin transporter affects the sensitivity to carbon dioxide. Methods: Based on our previous work, wildtype and serotonin transporter deficient (+/–, –/–) mice were monitored while being exposed to carbon dioxide-enriched air. In wildtype and serotonin transporter +/– mice, also cardio-respiration was assessed. Results: For most behavioral measures under air exposure, wildtype and serotonin transporter +/– mice did not differ, while serotonin transporter –/– mice showed more fear-related behavior. Carbon dioxide exposure evoked a marked increase in fear-related behaviors, independent of genotype, with the exception of time serotonin transporter –/– mice spent in the center zone of the modified open field test and freezing in the two-chamber test. On the physiological level, when inhaling carbon dioxide, the respiratory system was strongly activated and heart rate decreased independent of genotype. Conclusion: Carbon dioxide is a robust fear-inducing stimulus. It evokes inhibitory behavioral responses such as decreased exploration and is associated with a clear respiratory profile independent of serotonin transporter genotype. }, author = {Leibold, Nicole K. and van den Hove, Daniel La and Weidner, Magdalena T. and Buchanan, Gordon F. and Steinbusch, Harry Wm and Lesch, Klaus-Peter and Schruers, Koen Rj}, doi = {10.1177/0269881120959611}, journal = {Journal of Psychopharmacology}, month = {oct}, pages = {1408-1417}, title = {Effect of serotonin transporter genotype on carbon dioxide-induced fear-related behavior in mice}, url = {https://oadoi.org/10.1177/0269881120959611}, volume = {34}, year = {2020} } @article{Mortimer2020, author = {Mortimer, Niall and Sánchez-Mora, Cristina and Rovira, Paula and Vilar-Ribó, Laura and Richarte, Vanesa and Corrales, Montse and Fadeuilhe, Christian and Rivero, Olga and Lesch, Klaus-Peter and Casas, Miguel and Ramos-Quiroga, Josep Antoni and Artigas, María Soler and Ribasés, Marta}, doi = {10.1016/j.euroneuro.2020.11.005}, journal = {European Neuropsychopharmacology}, month = {dec}, pages = {160-166}, title = {Transcriptome profiling in adult attention-deficit hyperactivity disorder}, url = {https://oadoi.org/10.1016/j.euroneuro.2020.11.005}, volume = {41}, year = {2020} } @article{Muzerelle2021, abstract = {AbstractProper maternal care is an essential factor of reproductive success in mammals, involving a repertoire of behaviors oriented toward the feeding and care of the offspring. Among the neurotransmitters involved in the initiation of these behaviors, serotonin (5-HT) seems to play an important role. Here we compared pup-oriented maternal behaviors in mice with constitutive 5-HT depletion, the tryptophan hydroxylase 2-knock-out (Tph2-KO) and the Pet1-KO mice. We report that the only common pup-oriented defect in these 2 hyposerotoninergic models is a defective nursing in parturient mice and altered nursing-like (crouching) behavior in virgin mice, while pup retrieval defects are only present in Tph2-KO. Despite a normal mammary gland development and milk production, the defect in appropriate nursing is responsible for severe growth retardation and early lethality of pups born to hyposerotonergic dams. This nursing defect is due to acute rather constitutive 5-HT depletion, as it is reproduced by adult knockdown of Tph2 in the dorsal raphe nucleus in mothers with a prior normal maternal experience. We conclude that 5-HT innervation from the dorsal raphe is required for both the initiation and maintenance of a normal nursing behavior. Our findings may be related to observations of reduced maternal/infant interactions in human depression.}, author = {Muzerelle, Aude and Soiza-Reilly, Mariano and Hainer, Cornelia and Ruet, Pierre-Louis and Lesch, Klaus-Peter and Bader, Michael and Alenina, Natalia and Scotto-Lomassese, Sophie and Gaspar, Patricia}, doi = {10.1038/s41598-021-84368-6}, journal = {Scientific Reports}, month = {mar}, title = {Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival}, url = {https://doi.org/10.1038/s41598-021-84368-6}, volume = {11}, year = {2021} } @article{Patel2021, author = {Patel, and Yash and del Mar Bonnin, Caterina and de la Foz, Victor Ortiz García and van Amelsvoort, Therese and van der Wee, Nic J. A. and van der Werff, Steven J. A. and van Haren, Neeltje E. M. and van Wingen, Guido A. and von Polier, Georg G. and van Rooij, Daan and van den Heuvel, Odile A. and van Erp, Theo G. M. and Parker, Nadine and Shin, Jean and Howard, Derek and French, Leon and Thomopoulos, Sophia I. and Pozzi, Elena and Abe, Yoshinari and Abé, Christoph and Anticevic, Alan and Alda, Martin and Aleman, Andre and Alloza, Clara and Alonso-Lana, Silvia and McIntosh, Andrew A. and Ameis, Stephanie H. and Anagnostou, Evdokia and Arango, Celso and Arnold, Paul D. and Asherson, Philip and Baranov, Alexandr and Assogna, Francesca and Bargalló, Núria and Auzias, Guillaume and Bau, Claiton H. D. and Ayesa-Arriola, Rosa and Baumeister, Sarah and Baune, Bernhard T. and Bakker, Geor and Bellgrove, Mark A. and Benedetti, Francesco and Banaj, Nerisa and Bertolino, Alessandro and Banaschewski, Tobias and Boedhoe, Premika S. W. and Bandeira, Cibele E. and Boks, Marco and Bollettini, Irene and Del Mar Bonnin, C. and Borgers, Tiana and Borgwardt, Stefan and Brandeis, Daniel and Brennan, Brian P. and Bruggemann, Jason M. and Bülow, Robin and Busatto, Geraldo F. and Calderoni, Sara and Calhoun, Vince D. and Calvo, Rosa and Canales-Rodríguez, Erick J. and Cannon, Dara M. and Carr, Vaughan J. and Cascella, Nicola and Cercignani, Mara and Chaim-Avancini, Tiffany M. and Christakou, Anastasia and Coghill, David and Conzelmann, Annette and Crespo-Facorro, Benedicto and Cubillo, Ana I. and Cullen, Kathryn R. and Cupertino, Renata B. and Roberts, Gloria and Glahn, David C. and Daly, Eileen and Dannlowski, Udo and Gogberashvili, Tinatin and Davey, Christopher G. and Goikolea, Jose M. and Denys, Damiaan and Gotlib, Ian H. and Deruelle, Christine and Goya-Maldonado, Roberto and Grabe, Hans J. and Di Giorgio, Annabella and Green, Melissa J. and Gur, R. E. and Dickie, Erin W. and Gur, R. C. and Grevet, Eugenio H. and Dima, Danai and Groenewold, Nynke A. and Dohm, Katharina and Grotegerd, Dominik and Ehrlich, Stefan and Gruber, Oliver and Ely, Benjamin A. and Gruner, Patricia and Guerrero-Pedraza, Amalia and Erwin-Grabner, Tracy and Ethofer, Thomas and Whalley, Heather C. and Fair, Damien A. and Haar, Shlomi and Fallgatter, Andreas J. and Haarman, Bartholomeus C. M. and Haavik, Jan and Faraone, Stephen V. and Hahn, Tim and Fatjó-Vilas, Mar and Hajek, Tomas and Fedor, Jennifer M. and Harrison, Benjamin J. and Gur, Raquel E. and Fitzgerald, Kate D. and Harrison, Neil A. and Gur, Ruben C. and Ford, Judith M. and Hartman, Catharina A. and Frodl, Thomas and Heslenfeld, Dirk J. and Fu, Cynthia H. Y. and Hibar, Derrek P. and Fullerton, Janice M. and Hilland, Eva and Gabel, Matt C. and Hirano, Yoshiyuki and Ho, Tiffany C. and Xu, Jian and Hoekstra, Pieter J. and Hoekstra, Liesbeth and Hohmann, Sarah and Hong, L. E. and Höschl, Cyril and Høvik, Marie F. and Howells, Fleur M. and Nenadic, Igor and Jalbrzikowski, Maria and James, Anthony C. and Janssen, Joost and Jaspers-Fayer, Fern and Jonassen, Rune and Karkashadze, Georgii and King, Joseph A. and Kircher, Tilo and Kirschner, Matthias and Koch, Kathrin and Kochunov, Peter and Portella, Maria J. and Kohls, Gregor and Konrad, Kerstin and Krämer, Bernd and Krug, Axel and Kuntsi, Jonna and Kwon, Jun Soo and Landén, Mikael and Landrø, Nils I. and Lazaro, Luisa and Lebedeva, Irina S. and Leehr, Elisabeth J. and Lera-Miguel, Sara and Lesch, Klaus-Peter and Lochner, Christine and Louza, Mario R. and Luna, Beatriz and Lundervold, Astri J. and Ramos-Quiroga, J. A. and Macmaster, Frank P. and Maglanoc, Luigi A. and Malpas, Charles B. and Marsh, Rachel and Martyn, Fiona M. and Picó-Pérez, Maria and Mataix-Cols, David and Picon, Felipe A. and Mathalon, Daniel H. and Piras, Fabrizio and McCarthy, Hazel and McDonald, Colm and Plessen, Kerstin J. and McPhilemy, Genevieve and Pomarol-Clotet, Edith and Meinert, Susanne and Preda, Adrian and Menchón, José M. and Puig, Olga and Minuzzi, Luciano and Mitchell, Philip B. and Quidé, Yann and Radua, Joaquim and Moreno, Carmen and Morgado, Pedro and O′Gorman Tuura, Ruth L. and Muratori, Filippo and O′Hearn, Kirsten and Rasser, Paul E. and Murphy, Clodagh M. and Rauer, Lisa and Murphy, Declan and Reddy, Janardhan and Mwangi, Benson and Redlich, Ronny and Nabulsi, Leila and Reif, Andreas and Nakagawa, Akiko and Reneman, Liesbeth and Nakamae, Takashi and Repple, Jonathan and Namazova, Leyla and Retico, Alessandra and Narayanaswamy, Janardhanan and Richarte, Vanesa and Jahanshad, Neda and Piras, Federica and Richter, Anja and Nguyen, Danai D. and Rosa, Pedro G. P. and Nicolau, Rosa and Rubia, Katya K. and Sacchet, Matthew D. and Antoni Ramos Quiroga, J. and Oosterlaan, Jaap and Salvador, Raymond and Opel, Nils and Santonja, Javier and Ophoff, Roel A. and Sarink, Kelvin and Oranje, Bob and Sarró, Salvador and Overs, Bronwyn J. and Satterthwaite, Theodore D. and Sawa, Akira and Paloyelis, Yannis and Schall, Ulrich and Pantelis, Christos and Schofield, Peter R. and Parellada, Mara and Pauli, Paul and Schrantee, Anouk and Seitz, Jochen and O'Gorman Tuura, R. L. and Serpa, Mauricio H. and Setién-Suero, Esther and O'Hearn, K. and Shaw, Philip and Shook, Devon and Silk, Tim J. and Sim, Kang and Simon, Schmitt and Simpson, Helen Blair and Singh, Aditya and Skoch, Antonin and García De La Foz, V. O. and Hashimoto, Ryota and Skokauskas, Norbert and Soares, Jair C. and Soreni, Noam and Soriano-Mas, Carles and Spalletta, Gianfranco and Spaniel, Filip and Stewart, S. E. and Stern, Emily R. and Takayanagi, Yoichiro and Evelyn Stewart, S. and Temmingh, Henk S. and Tolin, David F. and Tomecek, David and Tordesillas-Gutiérrez, Diana and Tosetti, Michela and Uhlmann, Anne and Van Amelsvoort, T. and Van Der Wee, N. J. A. and Lawrie, Stephen M. and Van Der Werff, S. J. A. and Van Haren, N. E. M. and Van Wingen, G. A. and Vance, Alasdair and Vázquez-Bourgon, Javier and Vecchio, Daniela and Venkatasubramanian, Ganesan and Vieta, Eduard and Vilarroya, Oscar and Vives-Gilabert, Yolanda and Voineskos, Aristotle N. and Völzke, Henry and Von Polier, G. G. and Walton, Esther and Weickert, Thomas W. and Weickert, Cynthia Shannon and Weideman, Andrea S. and Wittfeld, Katharina and Wolf, Daniel H. and Wu, Mon-Ju and Yang, T. T. and Yang, Kun and Yoncheva, Yuliya and Yun, Je-Yeon and Zanetti, Marcus V. and Van Rooij, D. and Cheng, Yuqi and Ziegler, Georg C. and Franke, Barbara and Veltman, Dick J. and Hoogman, Martine and Disorder, Writing Committee for the Attention-Deficit/Hyperactivity and Schmaal, Lianne and Stein, Dan J. and Van Den Heuvel, O. A. and Buitelaar, Jan K. and Andreassen, Ole A. and Disorder, Autism Spectrum and Turner, Jessica A. and Ching, Christopher R. K. and Van Erp, T. G. M. and Pausova, Zdenka and Thompson, Paul M. and Disorder, Bipolar and , and Paus, Tomáš and McPhilemey, G. and Disorder, Depressive and And, }, month = {jan}, title = {Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders}, year = {2021} } @article{Postema2021, author = {Postema, Merel C. and Zeeuw, Patrick and de Zeeuw, P. and Høvik, Marie F. and Weiss, Eileen Oberwelland and Jernigan, Terry L. and Kardatzki, Bernd and Karkashadze, Georgii and Baranov, Alexandr and Kelly, Clare and Bau, Claiton H. D. and Kohls, Gregor and Baumeister, Sarah and Konrad, Kerstin and Bellgrove, Mark A. and Kuntsi, Jonna and Lazaro, Luisa and Biederman, Joseph and Baur-Streubel, R. and Bralten, Janita and Lesch, Klaus‐Peter-P. and Brandeis, Daniel and Louza, Mario R. and Lera-Miguel, S. and Brem, Silvia and Lundervold, Astri J. and Buitelaar, Jan K. and Malpas, Charles B. and Busatto, Geraldo F. and Mattos, Paulo and Castellanos, Francisco X. and McCarthy, Hazel and Cercignani, Mara and van Erp, T. G. M. and Chantiluke, Kaylita C. and Nicolau, Rosa and Tovar-Moll, F. and Namazova-Baranova, L. and Christakou, Anastasia and Nigg, Joel T. and Chaim-Avancini, T. M. and Coghill, David and Novotny, Stephanie E. and von Polier, G. G. and Hoogman, Martine and Vives-Gilabert, Y. and Conzelmann, Annette and Vance, Alasdair and Cubillo, Ana I. and O'Gorman Tuura, Ruth L. and Vilarroya, Oscar and Oosterlaan, Jaap and Oberwelland Weiss, E. and Cupertino, Renata B. and Ambrosino, Sara and Oranje, Bob and Walitza, Susanne and Asherson, Philip and Doyle, Alysa E. and Paloyelis, Yannis and Banaschewski, Tobias and Durston, Sarah and Yoncheva, Yuliya N. and Polier, Georg G. and Pauli, Paul and Bandeira, Cibele E. and Earl, Eric A. and Picon, Felipe A. and Zanetti, Marcus V. and Epstein, Jeffery N. and Plessen, Kerstin J. and Ethofer, Thomas and Ziegler, Georg C. and Fair, Damien A. and Reif, Andreas and Fallgatter, Andreas J. and Reneman, Liesbeth and Ramos-Quiroga, J. A. and Faraone, Stephen V. and Rosa, Pedro G. P. and Frodl, Thomas and Rubia, Katya and Gabel, Matt C. and Schrantee, Anouk and Gogberashvili, Tinatin and Schweren, Lizanne J. S. and Grevet, Eugenio H. and Seitz, Jochen and Haavik, Jan and Shaw, Philip and Harrison, Neil A. and Silk, Tim J. and Hartman, Catharina A. and Skokauskas, Norbert and Heslenfeld, Dirk J. and Soliva Vila, Juan C. and Hoekstra, Pieter J. and Stevens, Michael C. and Hohmann, Sarah and Sudre, Gustavo and Tamm, Leanne and Jahanshad, Neda and Medland, Sarah E. and Thompson, Paul M. and Erp, Theo G. M. and Glahn, David C. and Fisher, Simon E. and Franke, Barbara and Francks, Clyde and Antoni Ramos‐Quiroga, J.}, month = {jan}, title = {Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets}, year = {2021} } @article{Strekalova2020, author = {Strekalova, Tatyana and Svirin, Evgeniy and Waider, Jonas and Gorlova, Anna and Cespuglio, Raymond and Kalueff, Allan and Pomytkin, Igor and Schmitt-Boehrer, Angelika G. and Lesch, Klaus-Peter and Anthony, Daniel C.}, doi = {10.1016/j.pnpbp.2020.110155}, journal = {Progress in Neuro-Psychopharmacology and Biological Psychiatry}, month = {oct}, pages = {110155}, title = {Altered behaviour, dopamine and norepinephrine regulation in stressed mice heterozygous in TPH2 gene}, url = {https://oadoi.org/10.1016/j.pnpbp.2020.110155}, volume = {108}, year = {2020} } @article{Strekalova2022, abstract = {Abstract Rationale The chronic mild stress (CMS) paradigm was first described almost 40 years ago and has become a widely used model in the search for antidepressant drugs for major depression disorder (MDD). It has resulted in the publication of almost 1700 studies in rats alone. Under the original CMS procedure, the expression of an anhedonic response, a key symptom of depression, was seen as an essential feature of both the model and a depressive state. The prolonged exposure of rodents to unpredictable/uncontrollable mild stressors leads to a reduction in the intake of palatable liquids, behavioral despair, locomotor inhibition, anxiety-like changes, and vegetative (somatic) abnormalities. Many of the CMS studies do not report these patterns of behaviors, and they often fail to include consistent molecular, neuroanatomical, and physiological phenotypes of CMS-exposed animals. Objectives To critically review the CMS studies in rats so that conceptual and methodological flaws can be avoided in future studies. Results Analysis of the literature supports the validity of the CMS model and its impact on the field. However, further improvements could be achieved by (i) the stratification of animals into ‘resilient’ and ‘susceptible’ cohorts within the CMS animals, (ii) the use of more refined protocols in the sucrose test to mitigate physiological and physical artifacts, and (iii) the systematic evaluation of the non-specific effects of CMS and implementation of appropriate adjustments within the behavioral tests. Conclusions We propose methodological revisions and the use of more advanced behavioral tests to refine the rat CMS paradigm, which offers a valuable tool for developing new antidepressant medications. }, author = {Strekalova, Tatyana and Liu, Yanzhi and Kiselev, Daniel and Khairuddin, Sharafuddin and Chiu, Jennifer Lok Yu and Lam, Justin and Chan, Ying-Shing and Pavlov, Dmitrii and Proshin, Andrey and Lesch, Klaus-Peter and Anthony, Daniel C. and Lim, Lee Wei}, doi = {10.1007/s00213-021-05982-w}, journal = {Psychopharmacology}, month = {jan}, pages = {663-693}, title = {Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives}, url = {https://oadoi.org/10.1007/s00213-021-05982-w}, volume = {239}, year = {2022} } @article{Strekalova2022_2, abstract = {The phenomenon of individual variability in susceptibility/resilience to stress and depression, in which the hippocampus plays a pivotal role, is attracting increasing attention. We investigated the potential role of hippocampal cyclooxygenase-2 (COX-2), which regulates plasticity, neuroimmune function, and stress responses that are all linked to this risk dichotomy. We used a four-week-long chronic mild stress (CMS) paradigm, in which mice could be stratified according to their susceptibility/resilience to anhedonia, a key feature of depression, to investigate hippocampal expression of COX-2, a marker of microglial activation Iba-1, and the proliferation marker Ki67. Rat exposure, social defeat, restraints, and tail suspension were used as stressors. We compared the effects of treatment with either the selective COX-2 inhibitor celecoxib (30 mg/kg/day) or citalopram (15 mg/kg/day). For the celecoxib and vehicle-treated mice, the Porsolt test was used. Anhedonic (susceptible) but not non-anhedonic (resilient) animals exhibited elevated COX-2 mRNA levels, increased numbers of COX-2 and Iba-1-positive cells in the dentate gyrus and the CA1 area, and decreased numbers of Ki67-positive cells in the subgranular zone of the hippocampus. Drug treatment decreased the percentage of anhedonic mice, normalized swimming activity, reduced behavioral despair, and improved conditioned fear memory. Hippocampal over-expression of COX-2 is associated with susceptibility to stress-induced anhedonia, and its pharmacological inhibition with celecoxib has antidepressant effects that are similar in size to those of citalopram.}, author = {Strekalova, Tatyana and Pavlov, Dmitrii and Trofimov, Alexander and Anthony, Daniel C. and Svistunov, Andrei and Proshin, Andrey and Umriukhin, Aleksei and Lyundup, Alexei and Lesch, Klaus-Peter and Cespuglio, Raymond}, doi = {10.3390/ijms23042061}, journal = {International Journal of Molecular Sciences}, month = {feb}, pages = {2061}, title = {Hippocampal Over-Expression of Cyclooxygenase-2 (COX-2) Is Associated with Susceptibility to Stress-Induced Anhedonia in Mice}, url = {https://doi.org/10.3390/ijms23042061}, volume = {23}, year = {2022} } @article{van't Ent2021, author = {van't Ent, D. and de la Foz, V. O.-G. and Völzke, H. and Dima, Danai and de Geus, Eco J. C. and de Haan, Lieuwe and Modabbernia, Amirhossein and de Zubicaray, Greig I. and den Braber, Anouk and Papachristou, Efstathios and Hulshoff Pol, H. E. and Jönsson, E. G. and Dorum, Erlend S. and Krämer, B. and Lázaro, L. and Agartz, Ingrid and Aghajani, Moji and Hosten, Norbert and Doucet, Gaelle E. and Howells, Fleur M. and Akudjedu, Theophilus N. and Huyser, Chaim and Albajes-Eizagirre, Anton and Alpert, Kathryn I. and Jahanshad, Neda and James, Anthony and Andreasen, Nancy C. and Jernigan, Terry L. and Andreassen, Ole A. and Jiang, Jiyang and Asherson, Philip and Banaschewski, Tobias and Alnæs, Dag and Joska, John A. and Gur, Rachel E. and Bargallo, Nuria and Gur, Ruben C. and Kahn, Rene and Baumeister, Sarah and Kalnin, Andrew and Baur-Streubel, Ramona and Kanai, Ryota and Bertolino, Alessandro and Klein, Marieke and Bonvino, Aurora and Meinert, S. and Klyushnik, Tatyana P. and Boomsma, Dorret I. and Koenders, Laura and Borgwardt, Stefan and Koops, Sanne and Bourque, Josiane and Brandeis, Daniel and Kuntsi, Jonna and Breier, Alan and Andersson, Micael and Lagopoulos, Jim and Brodaty, Henry and Brouwer, Rachel M. and Tomyshev, Alexander S. and Lebedeva, Irina and Buitelaar, Jan K. and Tordesillas-Gutiérrez, Diana and Lee, Won Hee and Busatto, Geraldo F. and Trollor, Julian N. and Lesch, Klaus-Peter and Buckner, Randy L. and Turner, Jessica A. and Lochner, Christine and Calhoun, Vincent and Pol, Hilleke E. Hulshoff and Uhlmann, Anne and Machielsen, Marise W. J. and Canales-Rodríguez, Erick J. and van den Heuvel, Odile A. and Maingault, Sophie and Cannon, Dara M. and van den Meer, Dennis and Martin, Nicholas G. and Caseras, Xavier and van der Wee, Nic J. A. and Martínez-Zalacaín, Ignacio and Castellanos, Francisco X. and van Haren, Neeltje E. M. and Mataix-Cols, David and Cervenka, Simon and Mazoyer, Bernard and Chaim-Avancini, Tiffany M. and Jonsson, Erik G. and van Erp, Theo G. M. and McDonald, Colm and Ching, Christopher R. K. and Veer, Ilya M. and McDonald, Brenna C. and Chubar, Victoria and Veltman, Dick J. and McIntosh, Andrew M. and Clark, Vincent P. and Voineskos, Aristotle and McMahon, Katie L. and Conrod, Patricia and McPhilemy, Genevieve and Ge, Doucet and Conzelmann, Annette and Walter, Henrik and Menchón, Jose M. and Crespo-Facorro, Benedicto and Walton, Esther and Sánchez-Juan, P. and Medland, Sarah E. and Crivello, Fabrice and Wang, Lei and Meyer-Lindenberg, Andreas and Crone, Eveline A. and Wang, Yang and Naaijen, Jilly and Kraemer, Bernd and Wassink, Thomas H. and Dale, Anders M. and Najt, Pablo and Weber, Bernd and Davey, Cristopher and Nakao, Tomohiro and Wen, Wei and Nordvik, Jan E. and Lazaro, Luisa and West, John D. and Nyberg, Lars and Westlye, Lars T. and Dickie, Erin W. and Oosterlaan, Jaap and Whalley, Heather and Di Giorgio, Annabella and Wierenga, Lara M. and Paloyelis, Yannis and Doan, Nhat Trung and Williams, Steven C. R. and Pauli, Paul and Wittfeld, Katharina and Pergola, Giulio and Ehrlich, Stefan and Wolf, Daniel H. and Pomarol-Clotet, Edith and Erk, Susanne and Worker, Amanda and Portella, Maria J. and Espeseth, Thomas and Wright, Margaret J. and Potkin, Steven G. and Fatouros-Bergman, Helena and Yang, Kun and Radua, Joaquim and Fisher, Simon E. and Yoncheva, Yulyia and Reif, Andreas and Fouche, Jean-Paul and Zanetti, Marcus and Rinker, Daniel A. and Franke, Barbara and Ziegler, Georg C. and Roffman, Joshua L. and Frodl, Thomas and Rosa, Pedro G. P. and Fuentes-Claramonte, Paola and Tn, Akudjedu and Sacchet, Matthew D. and Glahn, David C. and Sachdev, Perminder S. and Gotlib, Ian H. and Salvador, Raymond and Grabe, Hans-Joergen and Grimm, Oliver and Sarró, Salvador and Groenewold, Nynke A. and Satterthwaite, Theodore D. and Grotegerd, Dominik and Saykin, Andrew J. and Gruber, Oliver and Serpa, Mauricio H. and Gruner, Patricia and Schmaal, Lianne and Schnell, Knut and Schumann, Gunter and Harrison, Ben J. and Ortiz-Garcia De la Foz, Victor and Sim, Kang and Hartman, Catharine A. and Smoller, Jordan W. and Hatton, Sean N. and Sommer, Iris and Heinz, Andreas and Soriano-Mas, Carles and Heslenfeld, Dirk J. and Stein, Dan J. and Hibar, Derrek P. and Strike, Lachlan T. and Hickie, Ian B. and Swagerman, Suzanne C. and Ho, Beng-Choon and Tamnes, Christian K. and Hoekstra, Pieter J. and Temmingh, Henk S. and Hohmann, Sarah and Thomopoulos, Sophia I. and Holmes, Avram J. and Hoogman, Martine and Sanchez-Juan, Pascual and Thompson, Paul M. and Dannlowski, U. and Ki, Alpert and Dørum, E. S. and Van't Ent, Dennis and Voelzke, Henry and Gur, R. E. and Gur, R. C. and Hahn, T. and (KaSP), Karolinska Schizophrenia Project and Frangou, Sophia}, month = {feb}, title = {Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years.}, year = {2021} } @article{van't Ent2021_2, author = {van't Ent, Dennis and Williams, Steven Charles Rees and Frangou, Sophia and van 't Ent, D. and Modabbernia, Amirhossein and Doucet, Gaelle E. and Vp, Clark and Papachristou, Efstathios and Alpert, Kathryn I. and Andreasen, Nancy C. and Akudjedu, Theophilus N. and Andreassen, Ole A. and Agartz, Ingrid and Nc, Andreasen and Aghajani, Moji and Boomsma, Dorret I. and Oa, Andreassen and Andersson, Micael and Jk, Buitelaar and Asherson, Philip and Banaschewski, Tobias and Buitelaar, Jan K. and Bargallo, Nuria and de Zubicaray, Greig I. and Albajes Eizagirre, Anton and Busatto, Geraldo F. and Rl, Buckner and den Braber, Anouk and Buckner, Randy L. and Baumeister, Sarah and Tm, Chaim Avancini and Baur Streubel, Ramona and Bertolino, Alessandro and Alnaes, Dag and Bonvino, Aurora and Chaim-Avancini, Tiffany M. and Scr, Williams and Clark, Vincent P. and de Haan, Lieuwe and Borgwardt, Stefan and Ge, Doucet and Bourque, Josiane and Crone, Eveline A. and Dale, Anders M. and Brandeis, Daniel and de Geus, Eco J. C. and Breier, Alan and Dørum, E. S. and Brodaty, Henry and Dickie, Erin W. and Di Giorgio, Annabella and Brouwer, Rachel M. and Doan, Nhat Trung and Ehrlich, Stefan and Erk, Susanne and Espeseth, Thomas and Fatouros-Bergman, Helena and Calhoun, Vincent and Dorum, Erlend S. and Fisher, Simon E. and Canales-Rodríguez, Erick Jorge and Fouche, Jean-Paul and Franke, Barbara and Cannon, Dara M. and Frodl, Thomas and Caseras, Xavier and Fuentes-Claramonte, Paola and Glahn, David C. and Gotlib, Ian H. and Castellanos, Francisco X. and Grabe, Hans-Joergen and Grimm, Oliver and Cervenka, Simon and Groenewold, Nynke A. and Grotegerd, Dominik and de la Foz, Victor Ortiz-Garcia and Gur, R. E. and Gruber, Oliver and Ching, Christopher R. K. and Gur, R. C. and Gruner, Patricia and Hahn, T. and Conrod, Patricia and Gur, Rachel E. and Harrison, Ben J. and Gur, Ruben C. and Hartman, Catharine A. and Conzelmann, Annette and Hatton, Sean N. and Heinz, Andreas and Crespo-Facorro, Benedicto and Heslenfeld, Dirk J. and Hibar, Derrek P. and Crivello, Fabrice and Hickie, Ian B. and Ho, Beng-Choon and Hoekstra, Pieter J. and Hohmann, Sarah and Holmes, Avram J. and Davey, Christopher and Hosten, Norbert and van den Heuvel, Odile A. and Howells, Fleur M. and Hulshoff Pol, H. E. and van den Meer, Dennis and Ki, Alpert and van der Wee, Nic J. A. and Pol, Hilleke E. Hulshoff and van Haren, Neeltje E. M. and Huyser, Chaim and Jahanshad, Neda and van Erp, Theo G. M. and James, Anthony and Jernigan, Terry L. and Di, Boomsma and Jiang, Jiyang and Jonsson, Erik G. and Jönsson, E. G. and Joska, John A. and Kahn, Rene and Kalnin, Andrew and Kanai, Ryota and Chubar, Viktoria and Klein, Marieke and Klyushnik, Tatyana P. and Koenders, Laura and Kraemer, Bernd and Koops, Sanne and Lazaro, Luisa and Kuntsi, Jonna and Lagopoulos, Jim and Krämer, B. and Lebedeva, Irina and Lee, Won Hee and Lázaro, L. and Lesch, Klaus-Peter and Lochner, Christine and Machielsen, Marise W. J. and Maingault, Sophie and Martin, Nicholas G. and Martínez-Zalacaín, Ignacio and Hoogman, Martine and Mataix-Cols, David and Mazoyer, Bernard and Dannlowski, U. and McDonald, Colm and McDonald, Brenna C. and McIntosh, Andrew M. and McMahon, Katie L. and McPhilemy, Genevieve and Menchón, Jose M. and Medland, Sarah E. and Meyer-Lindenberg, Andreas and Meinert, S. and Naaijen, Jilly and Najt, Pablo and Nakao, Tomohiro and Nordvik, Jan E. and Gf, Busatto and Nyberg, Lars and Oosterlaan, Jaap and Paloyelis, Yannis and Tn, Akudjedu and Pauli, Paul and Pergola, Giulio and Pomarol-Clotet, Edith and Portella, Maria J. and Potkin, Steven G. and Radua, Joaquim and Reif, Andreas and Rinker, Daniel A. and Roffman, Joshua L. and Rosa, Pedro G. P. and Sanchez-Juan, Pascual and Sacchet, Matthew D. and Sachdev, Perminder S. and Salvador, Raymond and Sarró, Salvador and Satterthwaite, Theodore D. and Saykin, Andrew J. and Sánchez-Juan, P. and Serpa, Mauricio H. and Schmaal, Lianne and Schnell, Knut and Schumann, Gunter and Sim, Kang and Smoller, Jordan W. and Sommer, Iris and Soriano-Mas, Carles and Stein, Dan J. and Strike, Lachlan T. and Swagerman, Suzanne C. and Tamnes, Christian K. and Temmingh, Henk S. and Thomopoulos, Sophia I. and Tomyshev, Alexander S. and Tordesillas-Gutiérrez, Diana and Trollor, Julian N. and Turner, Jessica A. and Uhlmann, Anne and Veer, Ilya M. and Veltman, Dick J. and Ea, Crone and Voineskos, Aristotle and Völzke, H. and Voelzke, Henry and Walter, Henrik and Walton, Esther and Am, Dale and Wang, Lei and Wang, Yang and Wassink, Thomas H. and Weber, Bernd and Wen, Wei and West, John D. and Westlye, Lars T. and Whalley, Heather and Wierenga, Lara M. and Wittfeld, Katharina and Wolf, Daniel H. and Ejc, de Geus and Worker, Amanda and Wright, Margaret J. and Yang, Kun and Yoncheva, Yulyia and Zanetti, Marcus and Ziegler, Georg C. and Thompson, Paul M. and Dima, Danai}, month = {feb}, title = {Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years.}, year = {2021} } @article{Vitale2021, author = {Vitale, Maria Rosaria and Zöller, Johanna Eva Maria and Jansch, Charline and Janz, Anna and Edenhofer, Frank and Klopocki, Eva and van den Hove, Daniel and Vanmierlo, Tim and Rivero, Olga and Kasri, Nael Nadif and Nadif Kasri, Nael and Ziegler, Georg Christoph and Lesch, Klaus-Peter}, doi = {10.1016/j.scr.2021.102169}, journal = {Stem Cell Research}, month = {jan}, pages = {102169}, title = {Generation of induced pluripotent stem cell lines deficient for Cadherin 13 (UKWMPi002-A-1/B/C) Bassociated with neurodevelopmental disorders using CRISPR/Cas9}, url = {https://doi.org/10.1016/j.scr.2021.102169}, volume = {51}, year = {2021} } @article{Walters2022, author = {Walters, G. Bragi and Walters, Raymond and Therrien, Karen and Farajzadeh, Leila and Voloudakis, Georgios and Zhang, Wen and Grove, Jakob and Zeng, Biao and Nielsen, Trine Tollerup and Duan, Jinjie and Kyle Satterstrom, F. and Satterstrom, F. Kyle and Gudmundsson, Olafur O. and Magnusson, Sigurdur H. and Haraldsdottir, Gyda S. and Hoffman, Gabriel E. and Martin, Joanna and Soler Artigas, Maria and Rajagopal, Veera M. and Ribasés, Marta and Roth Mota, Nina and Havdahl, Alexandra and Doyle, Alysa and Reif, Andreas and Thapar, Anita and Howrigan, Daniel and Liao, Calwing and Medland, Sarah E. and Mota, Nina Roth and Zayats, Tetyana and Rovaris, Diego Luiz and Sonuga-Barke, Edmund and Grevet, Eugenio Horacio and Larsson, Henrik and Gizer, Ian R. and Waldman, Irwin and Haavik, Jan and McGough, James and Kuntsi, Joanna and Glessner, Joseph and Langley, Kate and Lesch, Klaus-Peter and Rohde, Luis Augusto and Hutz, Mara H. and Klein, Marieke and Tesli, Martin and Manikandan, Veera and O’Donovan, Michael C. and Leung, Patrick W. L. and Pan, Pedro M. and Joober, Ridha and Schachar, Russel and Loo, Sandra and Witt, Stephanie H. and Reichborn-Kjennerud, Ted and Mors, Ole and Nordentoft, Merete and Hawi, Ziarih and Hougaard, David M. and Mortensen, Preben Bo and Faraone, Stephen V. and Stefansson, Hreinn and Roussos, Panos and Franke, Barbara and Werge, Thomas and Neale, Benjamin M. and Stefansson, Kari and Bragi Walters, G. and Athanasiadis, Georgios and Bendl, Jaroslav and Als, Thomas D. and Bybjerg-Grauholm, Jonas and Bækved-Hansen, Marie and Baldursson, Gisli and Davidsdottir, Katrin and Agerbo, Esben and Dalsgaard, Søren and Boomsma, Dorret I. and Cormand, Bru and Artigas, Maria Soler and Burton, Christie and Bau, Claiton H. D. and Demontis, Ditte and Corfield, Elizabeth and Brikell, Isabell and Crosbie, Jennifer and Bellgrove, Mark and Andreassen, Ole Andreas and Banaschewski, Tobias and Daly, Mark J. and Børglum, Anders D. and And, }, doi = {10.1016/j.euroneuro.2022.07.018}, journal = {Nature Genetics}, month = {feb}, pages = {198-208}, title = {Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains}, url = {https://doi.org/10.1016/j.euroneuro.2022.07.018}, volume = {55}, year = {2022} }