@article{Mikumo2015, author = {Mikumo, Hironori and Yanagihara, Toyoshi and Hamada, Naoki and Harada, Eiji and Inoshima, Ichiro and Ogata, Saiko and Suetsugu, Saiko Ogata and Ikeda-Harada, Chika and Harada, Chika Ikeda and Mizuta, Yuichi and Omori, Masako Arimura and Arimura-Omori, Masako and Suziki, Kunihiro and Suzuki, Kunihiro and Yokoyama, Tetsuya and Nakanishi, Yoichi}, doi = {10.1016/j.bbrc.2017.03.031}, journal = {European Respiratory Journal}, month = {sep}, pages = {PA3035}, title = {Neutrophil elastase inhibitor sivelestat ameliorates gefitinib, naphthalene-induced acute pneumonitis in mice}, url = {https://doi.org/10.1016/j.bbrc.2017.03.031}, volume = {46}, year = {2015} } @article{Suzuki2017, abstract = {Rationale: Bax is a pro-apoptotic member of the Bcl-2 family of proteins, and plays a central role in mitochondria-dependent apoptosis. Several lines of evidence have implied that Bax is involved in both epithelial apoptosis and fibroblast proliferation in idiopathic pulmonary fibrosis; however, the mechanisms remain unknown. Bax-inhibiting peptide V5 (BIP-V5) exhibits membrane permeability and inhibits the activation of Bax. Objective: The purpose of this study was to investigate whether the control of Bax activity by BIP-V5 reduces the degree of bleomycin-induced lung injury. Methods: C57BL/6J mice were administered bleomycin and BIP-V5 intratracheally on day 0. Bronchoalveolar lavage fluid and lung tissue were obtained on day 7. Human pulmonary alveolar epithelial cells (A549 cells) and mouse pulmonary alveolar epithelial cells (LA-4 cells ) were stimulated with bleomycin to induce apoptosis. Results: Administration of BIP-V5 improved the survival rate and degree of bleomycin-induced lung injury by suppressing Bax activation in mice. BIP-V5 treatment decreased bleomycin-induced apoptosis of alveolar epithelial cell lines (A549 cells and LA-4 cells) by suppressing Bax activation. Conclusions: The administration of BIP-V5 may constitute a novel therapeutic strategy against lung injury.}, author = {Suzuki, Kunihiro and Yanagihara, Toyoshi and Yokoyama, Tetsuya and Maeyama, Takashige and Ogata-Suetsugu, Saiko and Arimura-Omori, Masako and Mikumo, Hironori and Hamada, Naoki and Harada, Eiji and Kuwano, Kazuyoshi and Harada, Taishi and Nakanishi, Yoichi}, doi = {10.1242/bio.026005}, journal = {Biology Open}, month = {nov}, title = {Bax-inhibiting peptide attenuates bleomycin-induced lung injury in mice}, url = {https://doi.org/10.1242/bio.026005}, year = {2017} } @article{Yanagihara2017, author = {Yanagihara, Toyoshi and Tomino, Takahiro and Uruno, Takehito and Fukui, Yoshinori}, doi = {10.1016/j.bbrc.2017.05.113}, journal = {Biochemical and Biophysical Research Communications}, month = {jul}, pages = {8-13}, title = {Thymic epithelial cell–specific deletion of Jmjd6 reduces Aire protein expression and exacerbates disease development in a mouse model of autoimmune diabetes}, url = {https://doi.org/10.1016/j.bbrc.2017.05.113}, volume = {489}, year = {2017} } @article{Yanagihara2017_2, author = {Yanagihara, Toyoshi and Ikematsu, Yuki and Kato, Koji and Yonekawa, Akiko and Ideishi, Satoko and Tochigi, Taro and Sugio, Takeshi and Miyawaki, Kohta and Tanaka, Kentaro and Harada, Eiji and Hamada, Naoki and Nakanishi, Yoichi}, doi = {10.1007/s00277-017-3146-z}, journal = {Annals of Hematology}, month = {oct}, pages = {359-360}, title = {Expression of PD-1 and PD-L1 on cytotoxic T lymphocytes and immune deficiency in a patient with adult T cell leukemia/lymphoma}, url = {https://oadoi.org/10.1007/s00277-017-3146-z}, volume = {97}, year = {2017} } @article{Yanagihara2018, author = {Yanagihara, Toyoshi and Yamamoto, Norio and Kotetsu, Yasuaki and Hamada, Naoki and Harada, Eiji and Suzuki, Kunihiro and Ijichi, Kayo and Oda, Yoshinao and Nakanishi, Yoichi}, doi = {10.1016/j.rmcr.2017.10.009}, journal = {Respiratory Medicine Case Reports}, month = {jan}, pages = {10-12}, title = {Interstitial pneumonia caused by dabigatran}, url = {https://doi.org/10.1016/j.rmcr.2017.10.009}, volume = {23}, year = {2018} } @article{Yokoyama2017, author = {Yokoyama, Tetsuya and Yanagihara, Toyoshi and Suzuki, Kunihiro and Hamada, Naoki and Tsubouchi, Kazuya and Ogata-Suetsugu, Saiko and Mikumo, Hironori and Ikeda-Harada, Chika and Maeyama, Takashige and Kuwano, Kazuyoshi and Nakanishi, Yoichi}, doi = {10.1186/s12950-017-0168-1}, journal = {Journal of Inflammation}, month = {sep}, title = {Depletion of club cells attenuates bleomycin-induced lung injury and fibrosis in mice}, url = {https://doi.org/10.1186/s12950-017-0168-1}, volume = {14}, year = {2017} }