@article{Huang2013, abstract = {The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A viruses. We present the duck genome sequence and perform deep transcriptome analyses to investigate immune-related genes. Our data indicate that the duck possesses a contractive immune gene repertoire, as in chicken and zebra finch, and this repertoire has been shaped through lineage-specific duplications. We identify genes that are responsive to influenza A viruses using the lung transcriptomes of control ducks and ones that were infected with either a highly pathogenic (A/duck/Hubei/49/05) or a weakly pathogenic (A/goose/Hubei/65/05) H5N1 virus. Further, we show how the duck’s defense mechanisms against influenza infection have been optimized through the diversification of its β-defensin and butyrophilin-like repertoires. These analyses, in combination with the genomic and transcriptomic data, provide a resource for characterizing the interaction between host and influenza viruses.}, author = {Huang, Yinhua and Li, Yingrui and Zhang, Yong and Qian, Wubin and Kim, Heebal and Ke, Magor and Li, Jianwen and Yi, Kang and Zhao, Yiqiang and Burt, David W. and Zhu, Pengyang and Li, Bo and Kw, Kim and Liu, Qiuyue and Chen, Hualan and Magor, Katharine E. and Gan, Shangquan and Ma, Groenen and Hu, Xiaoxiang and Tafer, Hakim and Vignal, Alain and Rp, Crooijmans and Feng, Huapeng and Lee, Taeheon and Rg, Webster and Kim, Kyu-Won and Jr, Aldridge and Fairley, Suan and Sheng, Zheya and Du, Zhenlin and Wc, Warren and Searle, Steve and Pf, Stadler and Goodman, Laurie and Webster, Robert G. and Rh, Kraus and An, Yang and Warren, Wesley C. and Groenen, Martien A. M. and Kehr, Stephanie and Crooijmans, Richard P. M. A. and Herrero, Javier and Zhao, Yaofeng and Marz, Manja and Faraut, Thomas and Stadler, Peter F. and Smith, Jacqueline and Cai, Qingle and Kraus, Robert H. S. and Dw, Burt and Aldridge, Jerry R. and Ren, Liming and Bartschat, Sebastian and Morisson, Mireille and Kaiser, Pete and Rao, Man and Fei, Jing and Pitel, Frederique and Griffin, Darren K. and Wang, Jun and Li, Ning and Dk, Griffin}, doi = {10.1038/ng.2657}, journal = {Nature Genetics}, month = {jun}, pages = {776-783}, title = {The duck genome and transcriptome provide insight into an avian influenza virus reservoir species}, url = {http://www.nature.com/articles/ng.2657.pdf}, volume = {45}, year = {2013} }