@article{van der Grond2016, abstract = {Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (genetic = 0.748), which indicates a similar genetic background and allowed us to identify four additional loci through meta-analysis (N combined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, and Parkinson's disease, and were enriched near genes involved in growth pathways, including PI3K-AKT signaling. These findings identify the biological underpinnings of intracranial volume and their link to physiological and pathological traits. 2016 Nature America, Inc., part of Springer Nature. All rights reserved.}, author = {van der Grond, Jeroen and van der Lugt, Aad and van Donkelaar, Marjolein M. J. and van Eijk, Kristel R. and van der Meer, D. and van der Brug, Marcel and van der Wee, Nic J. A. and van Duijn, Cornelia M. and van Haren, Neeltje E. M. and van Tol, Marie-Jose and Adams, Hieab H. Hhh and Hibar, Derrek P. and Chouraki, Vincent and Stein, Jason L. and Nyquist, Paul A. and Rentería, Miguel E. and Trompet, Stella and Arias-Vasquez, Alejandro and Seshadri, Sudha and Beecham, Ashley H. and Van der Lee, Sven J. and Desrivières, Sylvane and Jahanshad, Neda and Wittfeld, Katharina and Abramovic, Lucija and Alhusaini, Saud and Amin, Najaf and Andersson, Micael and Arfanakis, Konstantinos and Aribisala, Benjamin S. and Armstrong, Nicola J. and Athanasiu, Lavinia and Bernard, Manon and Axelsson, Tomas and Bis, Joshua C. and Blanken, Laura M. E. and Blanton, Susan H. and Bohlken, Marc Mar and Bralten, Janita and Brickman, Adam M. and Carmichael, Owen and Chakravarty, Mm Mallar and Chauhan, Ganesh and Chen, Qiang and Van Der Lee, Sj and Cuellar-Partida, Gabriel and Braber, Anouk Den and Doan, Nhat Trung and Lee, Sven J. van der and Ehrlich, Stefan and Filippi, Irina and Ge, Tian and Giddaluru, Sudheer and Bernard, M. and Goldman, Aaron L. and Gottesman, Rebecca F. and Greven, Corina U. and Grimm, Oliver and Griswold, Michael E. and Beiser, Alex and Guadalupe, Tulio and Hass, Johanna and Haukvik, Unn K. and Hilal, Saima and Hofer, Edith and Hoehn, David and Bernard, Bernard and Holmes, Avram J. and Hoogman, Martine and Janowitz, Deborah and Jia, Tianye and Kasperaviciute, Dalia and Boks, Mar and Kim, Sungeun and Kraemer, Bernd and Ching, Christophe R. K. and Lee, Phil H. and Liao, Jiemin and Liewald, David C. M. and Lopez, Lorna M. and Luciano, Michelle and Macare, Christine and Marquand, Andre and Liao, Li and Matarin, Mar and Mather, Karen A. and Mattheisen, Manuel and Marquand, Mar and Mazoyer, Bernard and McKay, David R. and McWhirter, Rebekah and Milaneschi, Yuri and Ho, Edith and Mirza-Schreiber, Nazanin and Muetzel, Ryan L. and Maniega, Susana Muñoz and Nho, Kwangsik and Nugent, Allison C. and Ho, David and Loohuis, Loes M. Olde and Oosterlaan, Jaap and Papmeyer, Martina and Pappa, Irene and Pirpamer, Lukas and Pudas, Sara and Ho, Avram J. and Pütz, Benno and Rajan, Kumar B. and Ramasamy, Adaikalavan and Richards, Jennifer S. and Risacher, Shannon L. and Martin, Mar and Rommelse, Nanda and Rose, Emma J. and Royle, Natalie A. and Klein, Mar and Rundek, Tatjana and Sämann, Philipp G. and Satizabal, Claudia L. and Munoz Maniega, Susana and Schork, Andrew J. and Shen, Li and Shin, Jean and Shumskaya, Elena and Smith, Albert V. and Olde Loohuis, Loes M. and Sprooten, Emma and Strike, Lachlan T. and Van Erp, Theo G. M. and Thomson, Russell J. (R18461) and Tordesillas-Gutierrez, Diana and Martin, Martina and Roiz-Santiañez, Robert and Trabzuni, Daniah and Vaidya, Dhananjay and Schmaal, Li and Van der Meer, Dennis and Teumer, Alex and Toro, Robert and Donkelaar, Marjolein M. J. Van and Eijk, Kristel R. van and Van Rooij, Daan and Walton, Esther and Westlye, Lars T. and Rooij, Daan van and Whelan, Christophe D. and Windham, Beverly G. and Winkler, Anderson M. and Woldehawariat, Girma and Wolf, Christiane and Wolfers, Thomas W. and Xu, Bing and Van Der Grond, J. and Yanek, Lisa R. and Yang, Jingyun and Zijdenbos, Alex and Zwiers, Marcel P. and den Braber, A. and Agartz, Ingrid and Aggarwal, Neelum T. and Almasy, Laura and Ames, David A. and Van Donkelaar, Mmj and Amouyel, Philippe and Andreassen, Ole Andreas and Arepalli, Sampath and Assareh, Amelia Aa and Barral, Sandra and Bastin, Mark E. and Van Eijk, Kr and Becker, Diane M. and Becker, James T. and Bennett, David A. and Blangero, John B. and van Bokhoven, Hans and Van Erp, Tgm and Boomsma, Dorret I. and Brodaty, Henry and Brouwer, Rachel M. and Brunner, Han G. and Buckner, Randy L. and Bokhoven, Hans van and Buitelaar, Jan K. and Bulayeva, Kazima B. and Cahn, Wiepke and Calhoun, Vince D. and Ejc, de Geus and Cannon, Dara M. and Cavalleri, Gianpiero L. and Geus, Eco J. de and Cheng, Ching-Yu and Chen, Christophe and Cichon, Sven and Cookson, Mark R. and Corvin, Aiden and Crespo-Facorro, Benedicto and Jager, Philip L. de and Curran, Joanne E. and Czisch, Michael and Dale, Anders M. and Davies, Gareth E. and Zubicaray, Greig I. de and De Jager, Philip L. and de Geus, Eco J. C. and de Zubicaray, Greig I. and Delanty, Norman and Depondt, Chantal and DeStefano, Anita L. and Dillman, Allissa and De Geus, Ejc J. C. and Djurovic, Srdjan and Donohoe, Gary and Drevets, Wayne C. and Duggirala, Ravi and Dyer, Thomas D. and Erk, Susanne and Espeseth, Thomas E. and Evans, Denis A. and Fedko, Iryna O. and De Zubicaray, Gi and Fernández, Guillén and Ferrucci, Luigi and Fisher, Simon E. and Destefano, Al and Fleischman, Debra A. and Ford, Ian and Foroud, Tatiana M. and Fox, Peter T. and Francks, Clyde and Fukunaga, Masaki and Goring, Harald Hhh and Gibbs, J. Raphael and Glahn, David C. and Gollub, Randy L. and Göring, Harald H. H. and Grabe, Hans J. and Green, Robert C. and Gruber, Oliver and Gudnason, Vilmundur and Samann, Pg G. and Guelfi, Sebastian and Hansell, Narelle K. and Hardy, John and Hartman, Catharina A. and Hashimoto, Ryota and Hegenscheid, Katrin and Heinz, Andreas and Le Hellard, Stephanie and Hernandez, Dena G. and Heslenfeld, Dirk J. and Ho, Beng-Choon and Ho, B.-C. and Hoekstra, Pieter J. and Hoffmann, Wolfgang and Hofman, Albert and Holsboer, Florian and Homuth, Georg and Hosten, Norbert and Hottenga, Jouke-Jan and Hulshoff Pol, Hilleke E. and Jonsson, Eg and Pol, Hilleke E. Hulshoff and Ikeda, Masashi and Ikram, Mk Kamran and Jack, Clifford R. and Jenkinson, Mark and Jr, Clifford R. Jack and Johnson, Robert and Jönsson, Erik G. and Jukema, Jw Wouter and Kahn, René S. and Kanai, Ryota and Kloszewska, Iwona and Martin, Oliver and Knopman, David S. and Kochunov, Peter and Kwok, John B. and Lawrie, Stephen M. and Lemaître, Hervé and Liu, Xinmin and Longo, Dan L. and Longstreth, Wt T. and Jr, W. T. Longstreth and Lopez, Oscar L. and Lovestone, Simon and Martinez, Oliver P. and Martinot, Jean-Luc and Mattay, Venkata S. and Martin, Jean-Luc and McDonald, Colm and McIntosh, Andrew M. and McMahon, Katie L. and McMahon, Francis J. and Mcintosh, Andrew and Mecocci, Patrizia and Melle, Ingrid and Meyer-Lindenberg, Andreas and Mohnke, Sebastian and Montgomery, Grant W. and Morris, Derek W. and Nothen, Markus Mm and Mosley, Thomas H. and Mühleisen, Thomas W. and Müller-Myhsok, Bertram and Nalls, Michael A. and Nauck, Matthias and Nichols, Thomas E. and Niessen, Wiro J. and Nöthen, Markus M. and Nyberg, Lars and Ohi, Kazutaka and Olvera, Rene L. and Ophoff, Roel A. and Pandolfo, Massimo and Paus, Tomas and Pausova, Zdenka and Penninx, Brenda W. J. H. and van 't Ent, Dennis and Pike, Gb Bruce and Potkin, Steven G. and Psaty, Bruce M. and Rietschel, Marcel and Reppermund, Simone and de Craen, Anton J. M. and Roffman, Joshua L. and Romanczuk-Seiferth, Nina and Valdes Hernandez, Maria C. and Rotter, Jerome I. and Ryten, Mina and Sacco, Ralph L. and Sachdev, Perminder S. and Saykin, Andrew J. and Schmidt, Reinhold and Brug, Marcel van der and Schofield, Peter R. and Sigurdsson, Sigurdur and Simmons, Andy and Singleton, Andrew and Sisodiya, Sanjay M. and Lugt, Aad van der and Smith, Colin and Smoller, Jordan W. and Soininen, Hilkka and Srikanth, Velandai and Steen, Vidar M. and Stott, David J. and Wee, Nic J. van der and Sussmann, Jessika E. and Thalamuthu, Anbupalam and Tiemeier, Henning and Toga, Arthur W. and Traynor, Bryan J. and Troncoso, Juan and Duijn, Cornelia M. van and Turner, Jessica A. and Tzourio, Christophe and Uitterlinden, Andre G. and Van Der Lugt, A. and Hernández, Maria C. Valdés and Haren, Neeltje E. van and Van Der Wee, Nja and Ent, Dennis Van′t and Tol, Marie-Jose van and Van Duijn, Cm and Van ′t Ent, Dennis and Van Haren, Nem and Vardarajan, Badri N. and Veltman, Dick J. and Van T. Ent, Dennis and Vernooij, Meike W. and Völzke, Henry and Walter, Henrik and Wardlaw, Joanna M. and Wassink, Thomas H. and Weale, Michael E. and Weinberger, Wei and Weinberger, Daniel R. and Weiner, Michael Wei and Wen, Wei and Westman, Eric and White, Tonya and Wong, Tien Y. and Decarli, C. and Wright, Clinton B. and Zielke, Hr Ronald and Zonderman, Alan B. and Deary, Ian J. and DeCarli, Charles and Martin, Nicholas G. and Schmidt, Helena and Arfan Ikram, M. and Martin, N. G. and Wright, Margaret J. and Launer, Lenore J. and Schumann, Gunter and Craen, Anton J. de and Fornage, Myriam and Franke, Barbara and Debette, Stéphanie and Medland, Sarah E. and Martin, Ng and De Craen, Ajm and Ikram, M. Arfan and Thompson, Paul M.}, doi = {10.1038/nn.4398}, journal = {Nature Neuroscience}, month = {jan}, pages = {1569-1582}, title = {Novel genetic loci underlying human intracranial volume identified through genome-wide association}, url = {http://www.nature.com/articles/nn.4398.pdf}, volume = {19}, year = {2016} }