@article{Hou2016, abstract = {Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behaviour. Genome-wide association studies (GWAS) have identified several risk loci that together account for a small portion of the heritability. To identify additional risk loci, we performed a two-stage meta-analysis of >9 million genetic variants in 9,784 bipolar disorder patients and 30,471 controls, the largest GWAS of BD to date. In this study, to increase power we used ∼2,000 lithium-treated cases with a long-term diagnosis of BD from the Consortium on Lithium Genetics, excess controls, and analytic methods optimized for markers on the X-chromosome. In addition to four known loci, results revealed genome-wide significant associations at two novel loci: an intergenic region on 9p21.3 (rs12553324, P = 5.87 × 10 (-) (9); odds ratio (OR) = 1.12) and markers within ERBB2 (rs2517959, P = 4.53 × 10 (-) (9); OR = 1.13). No significant X-chromosome associations were detected and X-linked markers explained very little BD heritability. The results add to a growing list of common autosomal variants involved in BD and illustrate the power of comparing well-characterized cases to an excess of controls in GWAS.}, author = {Hou, Liping and Bergen, Sarah E. and Akula, Nirmala and Hultman, Christina M. and Song, Jie and Aubry, Jean-Michel and Badner, Judith A. and Barrett, Thomas B. and Landen, Mikael and Se, Bergen and Baune, Bernhard T. and Adli, Mazda and Berrettini, Wade H. and Bhattacharjee, Abesh Kumar and Alda, Martin and Biernacka, Joanna M. and Birner, Armin and Étain, Bruno and Bloss, Cinnamon S. and Ardau, Raffaella and Brichant-Petitjean, Clara and Bui, Elise T. and Arias, Barbara and Byerley, William and Cervantes, Pablo and Chillotti, Caterina and Cichon, Sven and Colom, Francesc and Backlund, Lena and Coryell, William and Craig, David W. and Cruceanu, Cristiana and Czerski, Piotr M. and Cm, Hultman and Davis, Tony and Dayer, Alexandre and Bauer, Michael and Degenhardt, Franziska and Del Zompo, Maria and DePaulo, J. Raymond and Edenberg, Howard J. and Etain, Bruno and Bellivier, Frank and Nothen, Markus M. and Falkai, Peter and Foroud, Tatiana and Forstner, Andreas J. and Benabarre, Antonio and Frisen, Louise and Frye, Mark A. and Bengesser, Susanne and Fullerton, Janice M. and Gard, Sebastien and Ösby, Urban and Garnham, Julie S. and Gershon, Elliot S. and Goes, Fernando S. and Greenwood, Tiffany A. and Grigoroiu-Serbanescu, Maria and Hauser, Joanna and Heilbronner, Urs and Heilmann-Heimbach, Stefanie and Osby, Urban and Herms, Stefan and Hipolito, Maria and Hitturlingappa, Shashi and Hoffmann, Per and Hofmann, Andrea and Jamain, Stephane and Jimenez, Esther and Kahn, Jean-Pierre and Kassem, Layla and Witt, Stephanie H. and Kelsoe, John R. and Wright, Adam and Kittel-Schneider, Sarah and Zandi, Peter P. and Kliwicki, Sebastian and Zhang, Peng and Zollner, Sebastian and Koller, Daniel L. and Konig, Barbara and Lackner, Nina and Laje, Gonzalo and Lang, Maren and Lavebratt, Catharina and Lawson, William B. and Leboyer, Marion and Leckband, Susan G. and Jm, Aubry and Liu, Chunyu and Maaser, Anna and Mahon, Pamela B. and Maier, Wolfgang and Maj, Mario and Manchia, Mirko and Mitchell, Philip B. and Martinsson, Lina and Mitjans, Marina and McCarthy, Michael J. and Mondimore, Francis M. and McElroy, Susan L. and Monteleone, Palmiero and McInnis, Melvin G. and Ja, Badner and McKinney, Rebecca and Muhleisen, Thomas W. and Nöthen, Markus M. and Nievergelt, Caroline M. and Novak, Tomas and Tb, Barrett and Nurnberger, John I. and Pfennig, Andrea and Nwulia, Evaristus A. and Potash, James B. and Propping, Peter and Reif, Andreas and Reininghaus, Eva and Rice, John and Rietschel, Marcella and Rouleau, Guy A. and Rybakowski, Janusz K. and Schalling, Martin and Scheftner, William A. and Schofield, Peter R. and Bt, Baune and Schork, Nicholas J. and Schulze, Thomas G. and Schumacher, Johannes and Schweizer, Barbara W. and Severino, Giovanni and Shekhtman, Tatyana and Shilling, Paul D. and Simhandl, Christian and Slaney, Claire M. and Smith, Erin N. and Squassina, Alessio and Stamm, Thomas and Strohmaier, Jana and Stopkova, Pavla and Szelinger, Szabolcs and Streit, Fabian and Tighe, Sarah K. and Tortorella, Alfonso and Turecki, Gustavo and Vieta, Eduard and Volkert, Julia and McMahon, Francis J. and Wh, Berrettini}, doi = {10.1093/hmg/ddw181}, month = {mar}, title = {Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder}, url = {https://academic.oup.com/hmg/article-pdf/25/15/3383/8624729/ddw181.pdf}, year = {2016} }