@article{van der Most2014, abstract = {Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP), we genotyped ∼50,000 SNPs in up to 87,736 individuals of European ancestry and combined these in a meta-analysis. We replicated findings in an independent set of 68,368 individuals of European ancestry. Our analyses identified 11 previously undescribed associations in independent loci containing 31 genes including PDE1A, HLA-DQB1, CDK6, PRKAG2, VCL, H19, NUCB2, RELA, HOXC@ complex, FBN1, and NFAT5 at the Bonferroni-corrected array-wide significance threshold (p < 6 × 10(-7)) and confirmed 27 previously reported associations. Bioinformatic analysis of the 11 loci provided support for a putative role in hypertension of several genes, such as CDK6 and NUCB2. Analysis of potential pharmacological targets in databases of small molecules showed that ten of the genes are predicted to be a target for small molecules. In summary, we identified previously unknown loci associated with BP. Our findings extend our understanding of genes involved in BP regulation, which may provide new targets for therapeutic intervention or drug response stratification.}, author = {van der Most, Pj and van Duijn, Cm and Tragante, Vinicius and van der Schouw, Yt and de Bakker, Pi and Guo, Wei and Barnes, Mr and Franceschini, Nora and Ganesh, Sk and Johnson, Toby and Lanktree, Mb and Padmanabhan, Sandosh and Smith, En and Almoguera, Berta and Barnard, John and Holmes, Mv and Baumert, Jens and Karczewski, Kj and Elbers, Clara Cc and Farrall, Martin and Chang, Yp and Gho, Jm and Fischer, Me and Gieger, Christian and Goel, Anuj and Gong, Yan and Isaacs, Aaron and Leach, Irene Mateo and Mateo Leach, Irene and Meijs, Matthijs F. L. and Gaunt, Tr and Melander, Olle and Van Iperen, Ep and Kleber, Me and Pankratz, Nathan and McDonough, Cw and Shaffer, Jonathan and Shah, Sonia and Tomaszewski, Maciej and Wong, Co and Nelson, Cp and Nolte, Im and Witkowska, Kate and Price, Ts and Zhang, Li and Vonk, Jm and Van Iperen, Epa and Brown, Morris and Beitelshees, Al and Burt, Amber and Berenson, Gs and Kees Hovingh, G. and Bhatt, Dl and Davey-Smith, George and Cooper-Dehoff, Rm and Connell, Jm and Delles, Christian and Cruickshanks, Kj and Guo, Xiuqing and Haiqing, Shen and Charlotte Onland Moret, N. and Curtis, Sp and Gansevoort, Rt and Hovingh, Gk Kees and Hastie, Ce and Ridker, Paul M. and Bezzina, Cr and Klein, Ronald and Hofker, Mh and Maiwald, Steffi and Newton-Cheh, Christopher and O’Brien, Eoin T. and Kim, Ds and Casas, Jp and Onland-Moret, Nc Charlotte and Palmas, Walter and Parsa, Afshin and Kirkland, Sa and Pettinger, Mary and Klein, Be and Caulfield, Mj and M. Ridker, Paul and Li, Yr and Sever, Peter and Shimbo, Daichi and Steele, Laura and Chasman, Di and Thorand, Barbara and Monique Verschuren, W. and Trip, Mieke D. and O'Brien, Et and Verschuren, Wm Monique and Wijmenga, Cisca and Wyatt, Sharon and Young, Jh Hunter and Davidson, Kw and Penninx, Bw and Boerwinkle, Eric and Hunter Young, J. and Doevendans, Pa and Chakravarti, Aravinda and Dominiczak, Af and FitzGerald, Ga and Vasan, Rs and Gums, Jg and Ranchalis, Je and Hillege, Hl and Fornage, Myriam and Hakonarson, Hakon and Halder, Indrani and Jarvik, Gp and Illig, Thomas and Johnson, Ja and Rose, Lm and Kastelein, Jj and Koenig, Wolfgang and Kumari, Meena and März, Winfried and Murray, Sarah Ss and Stolk, Rp and Maerz, Winfried and O’Connell, Jeffery R. and O'Connell, Jeffery R. and Redline, Susan and Oldehinkel, Aj and Reilly, Muredach P. and Schadt, Eric Ee and Kottke-Marchant, Kandice and Pankow, Js and Snieder, Harold and Snyder, Michael and Tobin, Martin D. and van der Harst, Pim and Zwinderman, Ah and Rader, Dj and Stanton, Av and Uitterlinden, Ag and Samani, Nj and Watkins, Hugh and Johnson, Ad and Reiner, Ap and Zhu, Xiaofeng and Levy, Daniel and Asselbergs, Fw and Munroe, Pb and Keating, Bj}, doi = {10.1016/j.ajhg.2013.12.016}, month = {mar}, title = {Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.}, url = {https://doi.org/10.1016/j.ajhg.2013.12.016}, year = {2014} }