@article{Tian2012, abstract = {With an increasing number of studies demonstrating alterations in T cell microRNA expression during autoimmune disease, modulation of the T cell microRNA network is considered a potential therapeutic strategy. Due to the complex and often opposing interactions of individual microRNA, prioritization of therapeutic targets first requires dissecting the dominant effects of the T cell microRNA network. Initial results utilizing a unidirectional screen suggested that the tolerogenic functions were dominant, with spontaneous colitis resulting from T cell-specific excision of Dicer. Here we performed a bidirectional screen for microRNA function by removing Dicer from the T cells of both wildtype mice and Transforming Growth Factor β (TGFβ) receptor-deficient mice. This allowed the impact of microRNA loss on T cell activation, effector T cell differentiation and autoimmune pathology to be systematically assessed. This bidirectional screen revealed a dominant immunogenic function for T cell microRNA, with potent suppression of T cell activation, IFNγ production and autoimmune pathology in all targeted organs except the colon, where Dicer-dependent microRNA demonstrated a dominant tolerogenic function. These results reverse the original conclusions of microRNA function in T cells by revealing a systemic pro-autoimmune function.}, author = {Tian, Lei and De Hertogh, Gert and Fedeli, Maya and Staats, Kim A. and Schonefeldt, Susann and Humblet-Baron, Stephanie and Van Den Bosch, Ludo and Dellabona, Paolo and Dooley, James and Liston, Adrian}, doi = {10.1016/j.jaut.2011.12.004}, journal = {Journal of Autoimmunity}, month = {feb}, pages = {39-48}, title = {Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice}, url = {https://www.researchgate.net/profile/Ludo_Van_Den_Bosch/publication/221729543_Loss_of_T_cell_microRNA_provides_systemic_protection_against_autoimmune_pathology_in_mice/links/0c96052ab22246dbee000000.pdf}, volume = {38}, year = {2012} }