@article{Peloso2014, abstract = {Low-frequency coding DNA sequence variants in the proprotein convertase subtilisin/kexin type 9 gene (PCSK9) lower plasma low-density lipoprotein cholesterol (LDL-C), protect against risk of coronary heart disease (CHD), and have prompted the development of a new class of therapeutics. It is uncertain whether the PCSK9 example represents a paradigm or an isolated exception. We used the "Exome Array" to genotype >200,000 low-frequency and rare coding sequence variants across the genome in 56,538 individuals (42,208 European ancestry [EA] and 14,330 African ancestry [AA]) and tested these variants for association with LDL-C, high-density lipoprotein cholesterol (HDL-C), and triglycerides. Although we did not identify new genes associated with LDL-C, we did identify four low-frequency (frequencies between 0.1% and 2%) variants (ANGPTL8 rs145464906 [c.361C>T; p.Gln121(∗)], PAFAH1B2 rs186808413 [c.482C>T; p.Ser161Leu], COL18A1 rs114139997 [c.331G>A; p.Gly111Arg], and PCSK7 rs142953140 [c.1511G>A; p.Arg504His]) with large effects on HDL-C and/or triglycerides. None of these four variants was associated with risk for CHD, suggesting that examples of low-frequency coding variants with robust effects on both lipids and CHD will be limited.}, author = {Peloso, Gina M. and Auer, Paul L. and Bis, Joshua C. and Voorman, Arend and Morrison, Alanna C. and Stitziel, Nathan O. and Brody, Jennifer A. and Khetarpal, Sumeet A. and Crosby, Jacy R. and Fornage, Myriam and Isaacs, Aaron and Jakobsdottir, Johanna and Feitosa, Mary F. and Davies, Gail and Huffman, Jennifer E. and Manichaikul, Ani and Davis, Brian and Lohman, Kurt and Joon, Aron Y. and Smith, Albert V. and Grove, Megan L. and Zanoni, Paolo and Redon, Valeska and Demissie, Serkalem and Lawson, Kim and Peters, Ulrike and Carlson, Christopher and Jackson, Rebecca D. and Ryckman, Kelli K. and Mackey, Rachel H. and Robinson, Jennifer G. and Siscovick, David S. and Schreiner, Pamela J. and Mychaleckyj, Josyf C. and Pankow, James S. and Hofman, Albert and Uitterlinden, André G and Harris, Tamara B. and Taylor, Kent D. and Stafford, Jeanette M. and Reynolds, Lindsay M. and Marioni, Riccardo E. and Dehghan, Abbas and Franco, Oscar H. and Patel, Aniruddh P. and Lu, Yingchang and Hindy, George and Gottesman, Omri and Bottinger, Erwin P. and Melander, Olle and Orho-Melander, Marju and Loos, Ruth J. F. and Duga, Stefano and Merlini, Piera Angelica and Farrall, Martin and Goel, Anuj and Asselta, Rosanna and Girelli, Domenico and Martinelli, Nicola and Shah, Svati H. and Kraus, William E. and Li, Mingyao and Rader, Daniel J. and Reilly, Muredach P. and Mcpherson, Ruth and Ida Chen, Y. D. and Watkins, Hugh and Ardissino, Diego and Zhang, Qunyuan and Wang, Judy and Tsai, Michael Y. and Taylor, Herman A. and Correa, Adolfo and Griswold, Michael E. and Lange, Leslie A. and Starr, John M. and Rudan, Igor and Eiriksdottir, Gudny and Launer, Lenore J. and Ordovas, Jose M. and Levy, Daniel and Chen, Yd-D. Ida and Reiner, Alexander P. and Hayward, Caroline and Polasek, Ozren and Deary, Ian J. and Borecki, Ingrid B. and Liu, Yongmei and Gudnason, Vilmundur and Wilson, James G. and van Duijn, Cornelia M. and Kooperberg, Charles and Rich, Stephen S. and Psaty, Bruce M. and Rotter, Jerome I. and O'Donnell, Cj and O’Donnell, Christopher J. and Rice, Kenneth and Boerwinkle, Eric and Kathiresan, Sekar and Adrienne Cupples, L. and Cupples, La Adrienne}, doi = {10.1016/j.ajhg.2014.01.009}, month = {feb}, title = {Association of Low-Frequency and Rare Coding-Sequence Variants with Blood Lipids and Coronary Heart Disease in 56,000 Whites and Blacks}, url = {https://doi.org/10.1016/j.ajhg.2014.01.009}, year = {2014} }