@article{Scott2012, abstract = {Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q < 0.05). Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on insulin resistance. Gene-based analyses identified further biologically plausible loci, suggesting that additional loci beyond those reaching genome-wide significance are likely to represent real associations. This conclusion is supported by an excess of directionally consistent and nominally significant signals between discovery and follow-up studies. Functional analysis of these newly discovered loci will further improve our understanding of glycemic control.}, author = {Scott, Robert A. and Lagou, Vasiliki and Welch, Rp P. and Wheeler, Eleanor and Welch, Ryan P. and Montasser, May E. and Strawbridge, Rona J. and Luan, Jian’an and Strawbridge, Rj J. and Rehnberg, Emil and MäGi, Reedik and Sm, Willems and Yengo, Loïc and Gustafsson, Stefan and Yengo, Loic and Wouter Jukema, J. and Kanoni, Stavroula and Shungin, Dmitry and Lecoeur, Cecile and Rasmussen-Torvik, Laura J. and Sanna, Serena and Rj, Loos and Sidore, Carlo and Tv, Varga and Johnson, Paul C. D. and Smith, Av and Jukema, Jw Wouter and Verweij, Niek and Johnson, Toby and Thorleifsson, Gudmar and Mahajan, Anubha and Sj, Bakker and Shah, Sonia and Hottenga, Jouke-Jan and Smith, Albert V. and Sennblad, Bengt and Gieger, Christian and Salo, Perttu and St Pourcain, Beate and Perola, Markus and Timpson, Nicholas J. and Evans, David M. and Pourcain, Beate St and Wu, Ying and Andrews, Jeanette S. and Zhao, Wei and Hui, Jennie and Voight, Bf and Sh, Wild and Bielak, Lawrence F. and Horikoshi, Momoko and Smith, George Davey and Stirrups, Kathleen and Navarro, Pau and Vitart, Veronique and Smith, G. D. and Isaacs, Aaron and O'Connell, Jeffrey R. and Smith, Gd and Voight, Benjamin F. and Sm, Keinänen Kiukaanniemi and Raychaudhuri, Soumya and Fraser, Ross M. and Hayward, Caroline and Te, Saaristo and Fall, Tove and Esko, Tonu and Tb, Harris and Rayner, Nigel W. and Mihailov, Evelin and Chen, Han and Robertson, Neil and Morris, Andrew P. and Lindgren, Cecilia M. and Rybin, Denis and Ra, Scott and Willems, Sara M. and Liu, Ching-Ti and Beckmann, Jacques S. and Cm, Lindgren and Stringham, Heather M. and Chines, Peter S. and Mägi, Reedik and Song, Kijoung and Jackson, Anne U. and Kang, Hyun Min-I.-N. and Tanaka, Toshiko and Ap, Morris and Peden, John F. and Goel, Anuj and Magi, Reedik and Nw, Rayner and Hicks, Andrew Aa and de Geus, Eco J. C. and Müller-Nurasyid, Martina and Ct, Liu and An, Ping and Franco-Cereceda, Anders and Js, Beckmann and Folkersen, Lasse and Ps, Chines and Marullo, Letizia and Jansen, Hanneke and Au, Jackson and Oldehinkel, Albertine J. and Bruinenberg, Marcel and Pankow, James S. and OĆonnell, and Varga, Tibor V. and van Duijn, Cornelia M. and North, Kari E. and Forouhi, Nita G. and Hm, Kang and Loos, Ruth J. F. and Edkins, Sarah and Hm, Stringham and Trompet, Stella and Hallmans, Göran and Oksa, Heikki and Jf, Peden and Antonella, Mulas and O’connell, Jeffrey R. and de Faire, Ulf and Nagaraja, Ramaiah and Ford, Ian and Aa, Hicks and Bakker, Stephan J. L. and Aj, Oldehinkel and Kong, Augustine and van der Harst, Pim and Js, Pankow and Gigante, Bruna and Kumari, Meena and Small, Kerrin and Herder, Christian and Ke, North and Munroe, Patricia B. and Ng, Forouhi and Rivadeneira, Fernando and Caulfield, Mark and Liu, Yongmei and Atalay, Mustafa and Uitterlinden, Andre G. and Antti, Jula and Mangino, Massimo and Kiess, Wieland and Miljkovic, Iva and James, Alan L. and Müller-Nurasyid, Martina and Willemsen, Gonneke and Smit, Johannes H. and Palmer, Colin N. A. and Doney, Alex S. F. and Campbell, Susan and Polasek, Ozren and Bonnycastle, Lori Ll and Hercberg, Serge and Dimitriou, Maria and Zemunik, Tatijana and Bolton, Jennifer L. and Fowkes, Gerard R. and Wild, Sarah H. and Kovacs, Peter and Lindström, Jaana and Esko, Tõnu and Rathmann, Wolfgang and Bandinelli, Stefania and Basart, Hanneke V. and Grallert, Harald and Maerz, Winfried and Kleber, Marcus E. and Pb, Munroe and Boehm, Bernhard O. and Peters, Annette and Rudan, Igor and Pramstaller, Peter Pp and Province, Michael A. and Watkins, Hugh and Borecki, Ingrid B. and Hastie, Nicholas D. and Stumvoll, Michael and Campbell, Harry and Waterworth, Dawn M. and Farrall, Martin and Al, James and Tuomilehto, Jaakko and Ferrucci, Luigi and Watanabe, Richard M. and Bergman, Richard N. and Muller-Nurasyid, Martina and Collins, Francis S. and Ag, Uitterlinden and Penninx, Brenda W. and Vollenweider, Peter and Hofman, Albert and De Geus, E. J. C. and Wilson, James F. and Oostra, Ben A. and Wright, Alan F. and Psaty, Bruce M. and Uusitupa, Matti and Hovingh, Gk Kees and Cn, Palmer and Metspalu, Andres and Magnusson, Patrik K. E. and Kyvik, Kirsten O. and As, Doney and Kaprio, Jaakko and Price, Jackie F. and Jh, Smit and Dedoussis, George V. and Van Duijn, C. M. and Shuldiner, Alan R. and Deloukas, Panos and Meneton, Pierre and Lind, Lars and Boehnke, Michael and Toenjes, Anke and Ll, Bonnycastle and Morris, Andrew D. and Peyser, Patricia A. and Jl, Bolton and Beilby, John P. and Schwarz, Peter E. H. and Körner, Antje and Kuusisto, Johanna and Gr, Fowkes and Rauramaa, Rainer and Laakso, Markku and Bornstein, Stefan R. and Lakka, Timo A. and Spector, Tim D. and Kees Hovingh, G. and Adair, Linda S. and Illig, Thomas and Faire, U. D. and Van Der Harst, P. and Hamsten, Anders and Saaristo, Timo E. and Gudnason, Vilmundur and Hv, Basart and Kivimaki, Mika and Hingorani, Aroon and Stefansson, Kari and Keinanen-Kiukaanniemi, Sirkka M. and Co, DIAbetes Genetics Replication and Meta-Analysis (Diagram) and Boomsma, Dorret I. and Sattar, Naveed and Körner, Antje and Dupuis, Josee and Pedersen, Nancy L. and Ripatti, Samuli and Korner, Antje and Salomaa, Veikko and Harris, Tamara B. and Cucca, Francesco and Davey Smith, George and Mohlke, Karen L. and Balkau, Beverley and Wareham, Nicholas J. and Froguel, Philippe and Di, Boomsma and Pouta, Anneli and Jarvelin, Marjo-Riitta and Nl, Pedersen and Bouatia-Naji, Nabila and Teslovich, Tanya M. and McCarthy, Mark I. and Franks, Paul W. and Meigs, James B. and Kl, Mohlke and Florez, Jose C. and Mr, Järvelin and Langenberg, Claudia and Ingelsson, Erik and Prokopenko, Inga and , and Barroso, Inês and Consortium, DIAbetes Genetics Replication and Meta-Analysis (Diagram)}, doi = {10.1038/ng.2385}, month = {aug}, title = {Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways}, url = {https://www.nature.com/articles/ng.2385.pdf}, year = {2012} }