@article{Ys2010, abstract = {Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2 diabetes. We report a meta-analysis of nine genome-wide association studies (n = 15,234 nondiabetic individuals) and a follow-up of 29 independent loci (n = 6,958-30,620). We identify variants at the GIPR locus associated with 2- h glucose level (rs10423928, beta (s.e.m.) = 0.09 (0.01) mmol/l per A allele, P = 2.0 x 10(-15)). The GIPR A-allele carriers also showed decreased insulin secretion (n = 22,492; insulinogenic index, P = 1.0 x 10(-17); ratio of insulin to glucose area under the curve, P = 1.3 x 10(-16)) and diminished incretin effect (n = 804; P = 4.3 x 10(-4)). We also identified variants at ADCY5 (rs2877716, P = 4.2 x 10(-16)), VPS13C (rs17271305, P = 4.1 x 10(-8)), GCKR (rs1260326, P = 7.1 x 10(-11)) and TCF7L2 (rs7903146, P = 4.2 x 10(-10)) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies (n = 35,869 cases, 89,798 controls, OR = 1.12, 95% CI 1.09-1.15, P = 4.8 x 10(-18)).}, author = {Ys, Aulchenko and Yd, Chen and Saxena, Richa and Hivert, Marie-France and Langenberg, Claudia and Linda Kao, W. H. and Pankow, James S. and Tanaka, Toshiko and Mf, Hivert and Ak, Manning and Vollenweider, Peter and Jackson, Anne U. and Hm, Stringham and Lyssenko, Valeriya and Kao, Wh H. Linda and Glazer, Nicole L. and Anluan, J. and Bouatia-Naji, Nabila and Manning, Alisa K. and Luan, Jian’an and Tw, Boesgaard and Dupuis, Josee and Stringham, Heather M. and Prokopenko, Inga and O’Connell, Jeffrey and Johnson, Toby and Grarup, Niels and Dj, Couper and Li, Man and Boesgaard, Trine W. and Oconnell, J. and Lecoeur, Cecile and Koettgen, Anna and Shrader, Peter and van Hoek, Mandy and Ingelsson, Erik and Ch, Andreasen and Couper, David J. and Js, Pankow and Rice, Kenneth and Bacquer, Olivier Le and Song, Kijoung and O'Connell, Jeffrey and Andreasen, Camilla H. and Dina, Christian and Mn, Weedon and Köttgen, Anna and Le Bacquer, Olivier and Böttcher, Yvonne and Pattou, François and Hoek, M. and Taneera, Jalal and Steinthorsdottir, Valgerdur and Bf, Voight and Rybin, Denis and Ardlie, Kristin and Rn, Bergman and Sampson, Michael and Qi, Lu and Boettcher, Yvonne and Weedon, Michael N. and Sj, Bielinski and Aulchenko, Yurii S. and Voight, Benjamin F. and Ll, Bonnycastle and Grallert, Harald and Balkau, Beverley and Ta, Buchanan and Bergman, Richard N. and Bielinski, Suzette J. and Bonnefond, Amélie and Sj, Bumpstead and Bonnycastle, Lori Ll and Wichmann, He Erich and Borch-Johnsen, Knut and Böttcher, Yvonne and Crawford, Gabriel J. and Au, Jackson and Brunner, Eric and Buchanan, Thomas A. and Bumpstead, Suzannah J. and Ps, Chines and Cavalcanti-Proença, Christine and Fs, Collins and Charpentier, Guillaume and Chen, Yii-Der Ida and Chines, Peter S. and Wh, Kao and Collins, Francis S. and Jm, Egan and Cornelis, Marilyn and Jørgensen, Torben and J. Crawford, Gabriel and Mr, Erdos and Delplanque, Jerome and Doney, Alex and Ng, Forouhi and Egan, Josephine M. and Erdos, Michael R. and Levy-Marchal, Claire and Firmann, Mathieu and Cs, Fox and Forouhi, Nita G. and Fox, Caroline S. and Goodarzi, Mark O. and Nl, Glazer and Graessler, Jürgen and Hingorani, Aroon and Isomaa, Bo and Mo, Goodarzi and Jorgensen, Torben and Apalmer, C. N. and Kivimaki, Mika and Wilson, James F. and Kovacs, Peter and Jùrgensen, T. and Krohn, Knut and Kumari, Meena and Jb, McAteer and Lauritzen, Torsten and Lévy-Marchal, Claire and Mayor, Vladimir and Bd, Mitchell and McAteer, Jarred B. and Meyre, David and Kl, Mohlke and Mitchell, Braxton D. and Tönjes, Anke and Mohlke, Karen L. and Williams, Gordon H. and Morken, Mario A. and Ma, Morken and Narisu, Narisu and Cn, Palmer and Palmer, Colin N. A. and Pakyz, Ruth and Pascoe, Laura and Toenjes, Anke and Payne, Felicity and Aa, Sayer and Pearson, Daniel and Rathmann, Wolfgang and Lj, Scott and Sandbaek, Annelli and Sayer, Avan Aihie and Van Duijn, Cornelia and Scott, Laura J. and Consortium, G. and Sharp, Stephen J. and Sj, Sharp and Illig, Thomas and Sijbrands, Eric and Ds, Siscovick and Singleton, Andrew and Erich Wichmann, H. and Nl, Smith and Zeggini, Eleftheria and Duijn, C. and Siscovick, David S. and Hu, Frank B. and Smith, Nicholas L. and Morris, Andrew D. and Zhao, Jing Hua and Frayling, Timothy M. and Sparsø, Thomas and Aj, Swift and Hattersley, Andrew T. and Swift, Amy J. and Sparsù, T. and Tt, Valle and Syddall, Holly and Thorsteinsdottir, Unnur and Thorleifsson, Gudmar and Stefansson, Kari and Nilsson, Peter and Tönjes, Anke and Syvanen, Ann-Christine and Shuldiner, Alan R. and Tuomi, Tiinamaija and Walker, Mark and Bornstein, Stefan R. and Tuomilehto, Jaakko and Dm, Waterworth and Valle, Timo Tt and Schwarz, Peter and Jh, Zhao and Waeber, Gerard and Nathan, David M. and Giant, Consortium and Walley, Andrew and Kuusisto, Johanna and Laakso, Markku and Waterworth, Dawn M. and Magic, Investigators and Cooper, Cyrus and Marmot, Michael and Ferrucci, Luigi and He, Wichmann and Mooser, Vincent and Stumvoll, Michael and Jf, Wilson and Loos, Ruth J. F. and Altshuler, David and Fb, Hu and Psaty, Bruce M. and Rotter, Jerome I. and Boerwinkle, Eric and Ad, Morris and Hansen, Torben and Pedersen, Oluf and Tm, Frayling and Florez, Jose C. and McCarthy, Mark I. and At, Hattersley and Boehnke, Michael and Barroso, Inês and Sladek, Robert and Ac, Syvänen and Froguel, Philippe and Meigs, James B. and Ar, Shuldiner and Groop, Leif and Wareham, Nicholas J. and Giant Consortium, Magic Investigators and Watanabe, Richard M. and Rm, Watanabe}, doi = {10.1038/ng.521}, month = {jan}, title = {Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge}, url = {http://www.nature.com/articles/ng.521.pdf}, year = {2010} }