@article{Katsanos2021, abstract = { Background and Purpose: We systematically evaluated the impact of the coronavirus 2019 (COVID-19) pandemic on stroke care across the world. Methods: Observational studies comparing characteristics, acute treatment delivery, or hospitalization outcomes between patients with stroke admitted during the COVID-19 pandemic and those admitted before the pandemic were identified by Medline, Scopus, and Embase databases search. Random-effects meta-analyses were conducted for all outcomes. Results: We identified 46 studies including 129 491 patients. Patients admitted with stroke during the COVID-19 pandemic were found to be younger (mean difference, −1.19 [95% CI, −2.05 to −0.32]; I 2 =70%) and more frequently male (odds ratio, 1.11 [95% CI, 1.01–1.22]; I 2 =54%) compared with patients admitted with stroke in the prepandemic era. Patients admitted with stroke during the COVID-19 pandemic, also, had higher baseline National Institutes of Health Stroke Scale scores (mean difference, 0.55 [95% CI, 0.12–0.98]; I 2 =90%), higher probability for large vessel occlusion presence (odds ratio, 1.63 [95% CI, 1.07–2.48]; I 2 =49%) and higher risk for in-hospital mortality (odds ratio, 1.26 [95% CI, 1.05–1.52]; I 2 =55%). Patients with acute ischemic stroke admitted during the COVID-19 pandemic had higher probability of receiving endovascular thrombectomy treatment (odds ratio, 1.24 [95% CI, 1.05–1.47]; I 2 =40%). No difference in the rates of intravenous thrombolysis administration or difference in time metrics regarding onset to treatment time for intravenous thrombolysis and onset to groin puncture time for endovascular thrombectomy were detected. Conclusions: The present systematic review and meta-analysis indicates an increased prevalence of younger patients, more severe strokes attributed to large vessel occlusion, and higher endovascular treatment rates during the COVID-19 pandemic. Patients admitted with stroke during the COVID-19 pandemic had higher in-hospital mortality. These findings need to be interpreted with caution in view of discrepant reports and heterogeneity being present across studies. }, author = {Katsanos, Aristeidis H. and Zand, Ramin and Yaghi, Shadi and Turc, Guillaume and Palaiodimou, Lina and Sharma, Vijay K. and Kamel, Hooman and Navi, Babak B. and Shoamanesh, Ashkan and Vadikolias, Konstantinos and Benetou, Vassiliki and Tsioufis, Konstantinos and Mavridis, Dimitris and Catanese, Luciana and Tsiodras, Sotirios and Shahjouei, Shima and Tsivgoulis, Georgios and Lagiou, Pagona and Sfikakis, Petros P. and Alexandrov, Andrei V.}, doi = {10.1161/strokeaha.121.034601}, journal = {Stroke}, month = {nov}, pages = {3651-3660}, title = {Changes in Stroke Hospital Care During the COVID-19 Pandemic: A Systematic Review and Meta-Analysis}, url = {https://oadoi.org/10.1161/strokeaha.121.034601}, volume = {52}, year = {2021} }