@article{Haslam2021, abstract = { Background: ChREBP (carbohydrate responsive element binding protein) is a transcription factor that responds to sugar consumption. Sugar-sweetened beverage (SSB) consumption and genetic variants in the CHREBP locus have separately been linked to HDL-C (high-density lipoprotein cholesterol) and triglyceride concentrations. We hypothesized that SSB consumption would modify the association between genetic variants in the CHREBP locus and dyslipidemia. Methods: Data from 11 cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (N=63 599) and the UK Biobank (N=59 220) were used to quantify associations of SSB consumption, genetic variants, and their interaction on HDL-C and triglyceride concentrations using linear regression models. A total of 1606 single nucleotide polymorphisms within or near CHREBP were considered. SSB consumption was estimated from validated questionnaires, and participants were grouped by their estimated intake. Results: In a meta-analysis, rs71556729 was significantly associated with higher HDL-C concentrations only among the highest SSB consumers (β, 2.12 [95% CI, 1.16–3.07] mg/dL per allele; P <0.0001), but not significantly among the lowest SSB consumers ( P =0.81; P Diff <0.0001). Similar results were observed for 2 additional variants (rs35709627 and rs71556736). For triglyceride, rs55673514 was positively associated with triglyceride concentrations only among the highest SSB consumers (β, 0.06 [95% CI, 0.02–0.09] ln-mg/dL per allele, P =0.001) but not the lowest SSB consumers ( P =0.84; P Diff =0.0005). Conclusions: Our results identified genetic variants in the CHREBP locus that may protect against SSB-associated reductions in HDL-C and other variants that may exacerbate SSB-associated increases in triglyceride concentrations. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT00005133, NCT00005121, NCT00005487, and NCT00000479. }, author = {Haslam, Danielle E. and Peloso, Gina M. and Guirette, Melanie and Imamura, Fumiaki and Bartz, Traci M. and Pitsillides, Achilleas N. and Wang, Carol A. and Li-Gao, Ruifang and Westra, Jason M. and Pitkänen, Niina and Young, Kristin L. and Graff, Mariaelisa and Wood, Alexis C. and Braun, Kim V. E. and Luan, Jian’an and Kähönen, Mika and Kiefte-De Jong, Jessica C. and Ghanbari, Mohsen and Tintle, Nathan and Lemaitre, Rozenn N. and Mook-Kanamori, Dennis O. and North, Kari and Helminen, Mika and Mossavar-Rahmani, Yasmin and Snetselaar, Linda and Martin, Lisa W. and Viikari, Jorma S. and Oddy, Wendy H. and Pennell, Craig E. and Rosendall, Frits R. and Ikram, M. Arfan and Uitterlinden, Andre G. and Psaty, Bruce M. and Mozaffarian, Dariush and Rotter, Jerome I. and Taylor, Kent D. and Lehtimäki, Terho and Raitakari, Olli T. and Livingston, Kara A. and Voortman, Trudy and Forouhi, Nita G. and Wareham, Nick J. and de Mutsert, Renée and Rich, Steven S. and Manson, JoAnn E. and Mora, Samia and Ridker, Paul M. and Merino, Jordi and Meigs, James B. and Dashti, Hassan S. and Chasman, Daniel I. and Lichtenstein, Alice H. and Smith, Caren E. and Dupuis, Josée and Herman, Mark A. and McKeown, Nicola M.}, doi = {10.1161/circgen.120.003288}, journal = {Circulation: Genomic and Precision Medicine}, month = {aug}, title = {Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations}, url = {https://oadoi.org/10.1161/circgen.120.003288}, volume = {14}, year = {2021} }