@article{Pemberton2021, abstract = {AbstractDevelopments in neuroradiological MRI analysis offer promise in enhancing objectivity and consistency in dementia diagnosis through the use of quantitative volumetric reporting tools (QReports). Translation into clinical settings should follow a structured framework of development, including technical and clinical validation steps. However, published technical and clinical validation of the available commercial/proprietary tools is not always easy to find and pathways for successful integration into the clinical workflow are varied. The quantitative neuroradiology initiative (QNI) framework highlights six necessary steps for the development, validation and integration of quantitative tools in the clinic. In this paper, we reviewed the published evidence regarding regulatory-approved QReports for use in the memory clinic and to what extent this evidence fulfils the steps of the QNI framework. We summarize unbiased technical details of available products in order to increase the transparency of evidence and present the range of reporting tools on the market. Our intention is to assist neuroradiologists in making informed decisions regarding the adoption of these methods in the clinic. For the 17 products identified, 11 companies have published some form of technical validation on their methods, but only 4 have published clinical validation of their QReports in a dementia population. Upon systematically reviewing the published evidence for regulatory-approved QReports in dementia, we concluded that there is a significant evidence gap in the literature regarding clinical validation, workflow integration and in-use evaluation of these tools in dementia MRI diagnosis.}, author = {Pemberton, Hugh G. and Zaki, Lara A. M. and Goodkin, Olivia and Das, Ravi K. and Steketee, Rebecca M. E. and Barkhof, Frederik and Vernooij, Meike W.}, doi = {10.1007/s00234-021-02746-3}, journal = {Neuroradiology}, month = {sep}, pages = {1773-1789}, title = {Technical and clinical validation of commercial automated volumetric MRI tools for dementia diagnosis—a systematic review}, url = {https://oadoi.org/10.1007/s00234-021-02746-3}, volume = {63}, year = {2021} }