@article{Mao2021, abstract = {Abstract Light is a key environmental cue that fundamentally regulates plant growth and development, which is mediated by the multiple photoreceptors including the blue light (BL) photoreceptor cryptochrome 1 (CRY1). The signaling mechanism of Arabidopsis thaliana CRY1 involves direct interactions with CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1)/SUPPRESSOR OF PHYA-105 1 and stabilization of COP1 substrate ELONGATED HYPOCOTYL 5 (HY5). H2A.Z is an evolutionarily conserved histone variant, which plays a critical role in transcriptional regulation through its deposition in chromatin catalyzed by SWR1 complex. Here we show that CRY1 physically interacts with SWC6 and ARP6, the SWR1 complex core subunits that are essential for mediating H2A.Z deposition, in a BL-dependent manner, and that BL-activated CRY1 enhances the interaction of SWC6 with ARP6. Moreover, HY5 physically interacts with SWC6 and ARP6 to direct the recruitment of SWR1 complex to HY5 target loci. Based on previous studies and our findings, we propose that CRY1 promotes H2A.Z deposition to regulate HY5 target gene expression and photomorphogenesis in BL through the enhancement of both SWR1 complex activity and HY5 recruitment of SWR1 complex to HY5 target loci, which is likely mediated by interactions of CRY1 with SWC6 and ARP6, and CRY1 stabilization of HY5, respectively.}, author = {Mao, Zhilei and Wei, Xuxu and Li, Ling and Xu, Peng and Zhang, Jingyi and Wang, Wenxiu and Guo, Tongtong and Kou, Shuang and Wang, Wanting and Miao, Langxi and Cao, Xiaoli and Zhao, Jiachen and Yang, Guangqiong and Zhang, Shilong and Lian, Hongli and Yang, Hong-Quan}, doi = {10.1093/plcell/koab091}, journal = {The Plant Cell}, month = {mar}, pages = {1961-1979}, title = {Arabidopsis cryptochrome 1 controls photomorphogenesis through regulation of H2A.Z deposition}, url = {https://oadoi.org/10.1093/plcell/koab091}, volume = {33}, year = {2021} }