@article{Gialluisi2020, abstract = {AbstractDevelopmental dyslexia (DD) is a learning disorder affecting the ability to read, with a heritability of 40–60%. A notable part of this heritability remains unexplained, and large genetic studies are warranted to identify new susceptibility genes and clarify the genetic bases of dyslexia. We carried out a genome-wide association study (GWAS) on 2274 dyslexia cases and 6272 controls, testing associations at the single variant, gene, and pathway level, and estimating heritability using single-nucleotide polymorphism (SNP) data. We also calculated polygenic scores (PGSs) based on large-scale GWAS data for different neuropsychiatric disorders and cortical brain measures, educational attainment, and fluid intelligence, testing them for association with dyslexia status in our sample. We observed statistically significant (p < 2.8 × 10−6) enrichment of associations at the gene level, forLOC388780(20p13; uncharacterized gene), and forVEPH1(3q25), a gene implicated in brain development. We estimated an SNP-based heritability of 20–25% for DD, and observed significant associations of dyslexia risk with PGSs for attention deficit hyperactivity disorder (atpT = 0.05 in the training GWAS: OR = 1.23[1.16; 1.30] per standard deviation increase;p = 8 × 10−13), bipolar disorder (1.53[1.44; 1.63];p = 1 × 10−43), schizophrenia (1.36[1.28; 1.45];p = 4 × 10−22), psychiatric cross-disorder susceptibility (1.23[1.16; 1.30];p = 3 × 10−12), cortical thickness of the transverse temporal gyrus (0.90[0.86; 0.96];p = 5 × 10−4), educational attainment (0.86[0.82; 0.91];p = 2 × 10−7), and intelligence (0.72[0.68; 0.76];p = 9 × 10−29). This study suggests an important contribution of common genetic variants to dyslexia risk, and novel genomic overlaps with psychiatric conditions like bipolar disorder, schizophrenia, and cross-disorder susceptibility. Moreover, it revealed the presence of shared genetic foundations with a neural correlate previously implicated in dyslexia by neuroimaging evidence.}, author = {Gialluisi, Alessandro and Andlauer, Till F. M. and Mirza-Schreiber, Nazanin and Moll, Kristina and Becker, Jessica and Hoffmann, Per and Ludwig, Kerstin U. and Czamara, Darina and Pourcain, Beate St and Honbolygó, Ferenc and Tóth, Dénes and Csépe, Valéria and Huguet, Guillaume and Chaix, Yves and Iannuzzi, Stephanie and Demonet, Jean-Francois and Morris, Andrew P. and Hulslander, Jacqueline and Willcutt, Erik G. and DeFries, John C. and Olson, Richard K. and Smith, Shelley D. and Pennington, Bruce F. and Vaessen, Anniek and Maurer, Urs and Lyytinen, Heikki and Peyrard-Janvid, Myriam and Leppänen, Paavo H. T. and Brandeis, Daniel and Bonte, Milene and Stein, John F. and Talcott, Joel B. and Fauchereau, Fabien and Wilcke, Arndt and Kirsten, Holger and Müller, Bent and Francks, Clyde and Bourgeron, Thomas and Monaco, Anthony P. and Ramus, Franck and Landerl, Karin and Kere, Juha and Scerri, Thomas S. and Paracchini, Silvia and Fisher, Simon E. and Schumacher, Johannes and Nöthen, Markus M. and Müller-Myhsok, Bertram and Schulte-Körne, Gerd}, doi = {10.1038/s41380-020-00898-x}, journal = {Molecular Psychiatry}, month = {oct}, pages = {3004-3017}, title = {Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia}, url = {https://oadoi.org/10.1038/s41380-020-00898-x}, volume = {26}, year = {2020} }