@article{Broer2014, abstract = {Oxidative stress and inflammation are major contributors to accelerated age-related relative telomere length (RTL) shortening. Both conditions are strongly linked to leptin and adiponectin, the most prominent adipocyte-derived protein hormones. As high leptin levels and low levels of adiponectin have been implicated in inflammation, one expects adiponectin to be positively associated with RTL while leptin should be negatively associated. Within the ENGAGE consortium, we investigated the association of RTL with adiponectin and leptin in seven independent cohorts with a total of 11,448 participants. We performed partial correlation analysis on Z-transformed RTL and LN-transformed leptin/adiponectin, adjusting for age and sex. In extended models we adjusted for body mass index (BMI) and C-reactive protein (CRP). Adiponectin showed a borderline significant association with RTL. This appeared to be determined by a single study and when the outlier study was removed, this association disappeared. The association between RTL and leptin was highly significant (r = -0.05; p = 1.81 × 10(-7)). Additional adjustment for BMI or CRP did not change the results. Sex-stratified analysis revealed no difference between men and women. Our study suggests that high leptin levels are associated with short RTL.}, author = {Broer, Linda and Raschenberger, Julia and Deelen, Joris and Mangino, Massimo and Codd, Veryan and Pietilainen, Kirsi H. and Albrecht, Eva and Amin, Najaf and Beekman, Marian and de Craen, Anton J. M. and De Craen, A. J. M. and Gieger, Christian and Haun, Margot and Henneman, Peter and Herder, Christian and Hovatta, Iiris and Laser, Annika and Kedenko, Lyudmyla and Koenig, Wolfgang and Kollerits, Barbara and Moilanen, Eeva and Oostra, Ben A. and Paulweber, Bernhard and Quaye, Lydia and Rissanen, Aila and Roden, Michael and Surakka, Ida and Valdes, Ana M. and Vuolteenaho, Katriina and Thorand, Barbara and van Dijk, Ko Willems and Kaprio, Jaakko and Spector, Tim D. and Eline Slagboom, P. and Slagboom, P. Eline and Samani, Nilesh J. and Kronenberg, Florian and van Duijn, Cornelia M. and Ladwig, Karl-Heinz}, doi = {10.1007/s10654-014-9940-1}, journal = {European Journal of Epidemiology}, month = {jul}, pages = {629-638}, title = {Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants}, url = {https://www.researchgate.net/profile/Peter_Henneman/publication/264633987_Association_of_adiponectin_and_leptin_with_relative_telomere_length_in_seven_independent_cohorts_including_11448_participants/links/53f1d5ce0cf26b9b7dd101b3.pdf}, volume = {29}, year = {2014} }