@article{Dashti2019, abstract = {AbstractSleep is an essential state of decreased activity and alertness but molecular factors regulating sleep duration remain unknown. Through genome-wide association analysis in 446,118 adults of European ancestry from the UK Biobank, we identify 78 loci for self-reported habitual sleep duration (p < 5 × 10−8; 43 loci at p < 6 × 10−9). Replication is observed for PAX8, VRK2, and FBXL12/UBL5/PIN1 loci in the CHARGE study (n = 47,180; p < 6.3 × 10−4), and 55 signals show sign-concordant effects. The 78 loci further associate with accelerometer-derived sleep duration, daytime inactivity, sleep efficiency and number of sleep bouts in secondary analysis (n = 85,499). Loci are enriched for pathways including striatum and subpallium development, mechanosensory response, dopamine binding, synaptic neurotransmission and plasticity, among others. Genetic correlation indicates shared links with anthropometric, cognitive, metabolic, and psychiatric traits and two-sample Mendelian randomization highlights a bidirectional causal link with schizophrenia. This work provides insights into the genetic basis for inter-individual variation in sleep duration implicating multiple biological pathways.}, author = {Dashti, Hassan S. and Jones, Samuel E. and Wood, Andrew R. and Lane, Jacqueline M. and van Hees, Vincent T. and Wang, Heming and Rhodes, Jessica A. and Song, Yanwei and Patel, Krunal and Anderson, Simon G. and Beaumont, Robin N. and Bechtold, David A. and Bowden, Jack and Cade, Brian E. and Garaulet, Marta and Kyle, Simon D. and Little, Max A. and Loudon, Andrew S. and Luik, Annemarie I. and Scheer, Frank A. J. L. and Spiegelhalder, Kai and Tyrrell, Jessica and Gottlieb, Daniel J. and Tiemeier, Henning and Ray, David W. and Purcell, Shaun M. and Frayling, Timothy M. and Redline, Susan and Lawlor, Deborah A. and Rutter, Martin K. and Weedon, Michael N. and Saxena, Richa}, doi = {10.1038/s41467-019-08917-4}, journal = {Nature Communications}, month = {mar}, title = {Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates}, url = {https://www.nature.com/articles/s41467-019-08917-4.pdf}, volume = {10}, year = {2019} }