@article{Nievergelt2019, abstract = {AbstractThe risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5–20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses stratified by sex implicate 3 additional loci in men. Along with other novel genes and non-coding RNAs, a Parkinson’s disease gene involved in dopamine regulation, PARK2, is associated with PTSD. Finally, we demonstrate that polygenic risk for PTSD is significantly predictive of re-experiencing symptoms in the Million Veteran Program dataset, although specific loci did not replicate. These results demonstrate the role of genetic variation in the biology of risk for PTSD and highlight the necessity of conducting sex-stratified analyses and expanding GWAS beyond European ancestry populations.}, author = {Nievergelt, Caroline M. and Maihofer, Adam X. and Klengel, Torsten and Atkinson, Elizabeth G. and Chen, Chia-Yen and Choi, Karmel W. and Coleman, Jonathan R. I. and Dalvie, Shareefa and Duncan, Laramie E. and Gelernter, Joel and Levey, Daniel F. and Logue, Mark W. and Polimanti, Renato and Provost, Allison C. and Ratanatharathorn, Andrew and Stein, Murray B. and Torres, Katy and Aiello, Allison E. and Almli, Lynn M. and Amstadter, Ananda B. and Andersen, Søren B. and Andreassen, Ole A. and Arbisi, Paul A. and Ashley-Koch, Allison E. and Austin, S. Bryn and Avdibegovic, Esmina and Babić, Dragan and Bækvad-Hansen, Marie and Baker, Dewleen G. and Beckham, Jean C. and Bierut, Laura J. and Bisson, Jonathan I. and Boks, Marco P. and Bolger, Elizabeth A. and Børglum, Anders D. and Bradley, Bekh and Brashear, Megan and Breen, Gerome and Bryant, Richard A. and Bustamante, Angela C. and Bybjerg-Grauholm, Jonas and Calabrese, Joseph R. and Caldas-De-Almeida, José M. and Dale, Anders M. and Daly, Mark J. and Daskalakis, Nikolaos P. and Deckert, Jürgen and Delahanty, Douglas L. and Dennis, Michelle F. and Disner, Seth G. and Domschke, Katharina and Dzubur-Kulenovic, Alma and Erbes, Christopher R. and Evans, Alexandra and Farrer, Lindsay A. and Feeny, Norah C. and Flory, Janine D. and Forbes, David and Franz, Carol E. and Galea, Sandro and Garrett, Melanie E. and Gelaye, Bizu and Geuze, Elbert and Gillespie, Charles and Uka, Aferdita Goci and Gordon, Scott D. and Guffanti, Guia and Hammamieh, Rasha and Harnal, Supriya and Hauser, Michael A. and Heath, Andrew C. and Hemmings, Sian M. J. and Hougaard, David Michael and Jakovljevic, Miro and Jett, Marti and Johnson, Eric Otto and Jones, Ian and Jovanovic, Tanja and Qin, Xue-Jun and Junglen, Angela G. and Karstoft, Karen-Inge and Kaufman, Milissa L. and Kessler, Ronald C. and Khan, Alaptagin and Kimbrel, Nathan A. and King, Anthony P. and Koen, Nastassja and Kranzler, Henry R. and Kremen, William S. and Lawford, Bruce R. and Lebois, Lauren A. M. and Lewis, Catrin E. and Linnstaedt, Sarah D. and Lori, Adriana and Lugonja, Bozo and Luykx, Jurjen J. and Lyons, Michael J. and Maples-Keller, Jessica and Marmar, Charles and Martin, Alicia R. and Martin, Nicholas G. and Maurer, Douglas and Mavissakalian, Matig R. and McFarlane, Alexander and McGlinchey, Regina E. and McLaughlin, Katie A. and McLean, Samuel A. and McLeay, Sarah and Mehta, Divya and Milberg, William P. and Miller, Mark W. and Morey, Rajendra A. and Morris, Charles Phillip and Mors, Ole and Mortensen, Preben B. and Neale, Benjamin M. and Nelson, Elliot C. and Nordentoft, Merete and Norman, Sonya B. and O’Donnell, Meaghan and Orcutt, Holly K. and Panizzon, Matthew S. and Peters, Edward S. and Peterson, Alan L. and Peverill, Matthew and Pietrzak, Robert H. and Polusny, Melissa A. and Rice, John P. and Ripke, Stephan and Risbrough, Victoria B. and Roberts, Andrea L. and Rothbaum, Alex O. and Rothbaum, Barbara O. and Roy-Byrne, Peter and Ruggiero, Ken and Rung, Ariane and Rutten, Bart P. F. and Saccone, Nancy L. and Sanchez, Sixto E. and Schijven, Dick and Seedat, Soraya and Seligowski, Antonia V. and Seng, Julia S. and Sheerin, Christina M. and Silove, Derrick and Smith, Alicia K. and Smoller, Jordan W. and Sponheim, Scott R. and Stein, Dan J. and Stevens, Jennifer S. and Sumner, Jennifer A. and Teicher, Martin H. and Thompson, Wesley K. and Trapido, Edward and Uddin, Monica and Ursano, Robert J. and van den Heuvel, Leigh Luella and Van Hooff, Miranda and Vermetten, Eric and Vinkers, Christiaan H. and Voisey, Joanne and Wang, Yunpeng and Wang, Zhewu and Werge, Thomas and Williams, Michelle A. and Williamson, Douglas E. and Winternitz, Sherry and Wolf, Christiane and Wolf, Erika J. and Wolff, Jonathan D. and Yehuda, Rachel and Young, Ross M.-C.-D. and Young, Keith A. and Zhao, Hongyu and Zoellner, Lori A. and Liberzon, Israel and Ressler, Kerry J. and Haas, Magali and Koenen, Karestan C.}, doi = {10.1038/s41467-019-12576-w}, journal = {Nature Communications}, month = {oct}, title = {International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci}, url = {https://www.nature.com/articles/s41467-019-12576-w.pdf}, volume = {10}, year = {2019} }