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All papers authored by Saranna Fanning

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2022 Saranna Fanning

ORCID

, Haley Cirka, Jennifer L. Thies

ORCID

, Jooyoung Jeong, Sarah M. Niemi, Joon Yoon

ORCID

, Gary P. H. Ho

ORCID

, Julian A. Pacheco

ORCID

ORCID

, Lei Liu

ORCID

, Clary B. Clish

ORCID

, Kevin J. Hodgetts, John N. Hutchinson

ORCID

, Christina R. Muratore, Guy A. Caldwell

ORCID

and 2 other authors

Lipase regulation of cellular fatty acid homeostasis as a Parkinson’s disease therapeutic strategy

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Silke Nuber, Chee Yeun Chung

ORCID

, Daniel F. Tardiff, Pascal A. Bechade, Thomas D. McCaffery, Kazuma Shimanaka, Jeonghoon Choi, Belle Chang, Waseem Raja, Esther Neves, Christopher Burke, Xin Jiang, Ping Xu, Vikram Khurana, Ulf Dettmer and 4 other authors

A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity

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Arati Tripathi

ORCID

, Heba Alnakhala, Elizabeth Terry-Kantor, Andrew Newman, Lei Liu, Thibaut Imberdis, Saranna Fanning

ORCID

, Silke Nuber, Nagendran Ramalingam, Dennis Selkoe, Ulf Dettmer

Pathogenic Mechanisms of Cytosolic and Membrane-Enriched α-Synuclein Converge on Fatty Acid Homeostasis

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2021 Arati Tripathi, Saranna Fanning

ORCID

ORCID

Lipotoxicity Downstream of α-Synuclein Imbalance: A Relevant Pathomechanism in Synucleinopathies?

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Tae-Eun Kim, Andrew J. Newman, Thibaut Imberdis, Lisa Brontesi, Arati Tripathi, Nagendran Ramalingam, Saranna Fanning

ORCID

, Dennis Selkoe, Ulf Dettmer

Excess membrane binding of monomeric alpha-, beta- and gamma-synuclein is invariably associated with inclusion formation and toxicity

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2020 Silke Nuber

ORCID

, Alice Y. Nam, Molly M. Rajsombath, Haley Cirka, Xiaoping Hronowski, Junmin Wang, Kevin Hodgetts, Liubov S. Kalinichenko, Christian P. Müller, Vera Lambrecht, Jürgen Winkler, Andreas Weihofen

ORCID

, Thibaut Imberdis, Ulf Dettmer, Saranna Fanning

ORCID

and 1 other authors

A Stearoyl–Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α‐Synuclein Mice

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Elizabeth Terry-Kantor, Arati Tripathi, Thibaut Imberdis

ORCID

, Zachary M. LaVoie

ORCID

, Gary P. H. Ho

ORCID

, Dennis Selkoe, Saranna Fanning

ORCID

, Nagendran Ramalingam, Ulf Dettmer

ORCID

Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor

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Saranna Fanning

ORCID

, Dennis Selkoe, Ulf Dettmer

ORCID

Vesicle trafficking and lipid metabolism in synucleinopathy

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Saranna Fanning

ORCID

, Dennis Selkoe, Ulf Dettmer

ORCID

Parkinson’s disease: proteinopathy or lipidopathy?

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2019 Thibaut Imberdis

ORCID

, Joseph Negri, Nagendran Ramalingam, Elizabeth Terry-Kantor, Gary P. H. Ho

ORCID

, Saranna Fanning

ORCID

, Georgia Stirtz, Tae-Eun Kim, Oren A. Levy, Tracy L. Young-Pearse, Dennis Selkoe

ORCID

, Ulf Dettmer

Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase

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Christina A. Cuomo

ORCID

, Saranna Fanning

ORCID

, Sharvari Gujja, Qiandong Zeng, Julian R. Naglik

ORCID

, Scott G. Filler

ORCID

, Aaron P. Mitchell

ORCID

Genome Sequence for Candida albicans Clinical Oral Isolate 529L

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Saranna Fanning

ORCID

, Aftabul Haque, Thibaut Imberdis, Valeriya Baru, M. Inmaculada Barrasa, Silke Nuber, Daniel Termine, Nagendran Ramalingam, Gary P. H. Ho

ORCID

, Tallie Noble, Jackson Sandoe, Yali Lou, Dirk Landgraf, Yelena Freyzon, Gregory Newby and 16 other authors

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

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Thibaut Imberdis, Saranna Fanning

ORCID

, Andrew Newman, Nagendran Ramalingam, Ulf Dettmer

Studying α-Synuclein Conformation by Intact-Cell Cross-Linking

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2018 Can Kayatekin

ORCID

, Audra Amasino, Giorgio Gaglia, Jason Flannick, Julia M. Bonner, Saranna Fanning

ORCID

, Priyanka Narayan, M. Inmaculada Barrasa, David Pincus, Dirk Landgraf, Justin Nelson, William R. Hesse, Michael Costanzo, Chad L. Myers, Charles Boone and 2 other authors

Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity

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2017 Gabriela Caraveo, Martin Soste, Valentina Cappelleti, Valentina Cappelletti, Saranna Fanning

ORCID

, Damian B. van Rossum, Luke Whitesell, Yanmei Huang, Chee Yeun Chung, Valeriya Baru, Sofia Zaichick, Paola Picotti, Susan Lindquist

FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome

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Ulf Dettmer, Nagendran Ramalingam, Victoria E. von Saucken, Tae-Eun Kim, Andrew J. Newman, Elizabeth Terry-Kantor, Silke Nuber, Maria Ericsson, Saranna Fanning

ORCID

, Tim Bartels, Susan Lindquist, Oren A. Levy, Dennis Selkoe

Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells

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Vikram Khurana, Jian Peng, Chee Yeun Chung, Pavan K. Auluck, Saranna Fanning

ORCID

, Daniel F. Tardiff, Theresa Bartels, Martina Koeva, Stephen W. Eichhorn, Hadar Benyamini, Yali Lou, Andy Nutter-Upham, Valeriya Baru, Yelena Freyzon, Nurcan Tuncbag and 15 other authors

Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways

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2014 Jill R. Blankenship, Shaoji Cheng, Carol A. Woolford, Wenjie Xu, Tanner M. Johnson, P. David Rogers, P. David Rogers, Saranna Fanning

ORCID

, M. Hong Nguyen, M. Hong Nguyen, Cornelius J. Clancy, Aaron P. Mitchell

Mutational Analysis of Essential Septins Reveals a Role for Septin-Mediated Signaling in Filamentation

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2013 Melanie L. Langford, Jessica C. Hargarten, Krista D. Patefield, Elizabeth Marta, Jill R. Blankenship, Saranna Fanning

ORCID

, Kenneth W. Nickerson, Audrey L. Atkin

Candida albicans Czf1 and Efg1 Coordinate the Response to Farnesol during Quorum Sensing, White-Opaque Thermal Dimorphism, and Cell Death

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Jigar V. Desai, Vincent M. Bruno, Shantanu Ganguly, Ronald J. Stamper, Kaitlin F. Mitchell, Norma Solis, Elizabeth M. Hill, Wenjie Xu, Scott G. Filler, David R. Andes, Saranna Fanning

ORCID

, Frederick Lanni, Aaron P. Mitchell

Regulatory Role of Glycerol in Candida albicans Biofilm Formation

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