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Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD
UploadTwo FTD-ALS genes converge on the endosomal pathway to induce TDP-43 pathology and degeneration
UploadPoly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins
UploadC9orf72 poly(GR) aggregation induces TDP-43 proteinopathy
UploadHeterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity
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