All papers authored by James Spencer
Refreshing results…
2023
Catherine L. Tooke 
,
Philip Hinchliffe ,
Michael Beer ,
Kirill Zinovjev ,
Charlotte K. Colenso,
Christopher J. Schofield ,
Adrian J. Mulholland ,
James Spencer
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,
Philip Hinchliffe ,
Michael Beer ,
Kirill Zinovjev ,
Charlotte K. Colenso,
Christopher J. Schofield ,
Adrian J. Mulholland ,
James Spencer
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2022
Ewa I. Chudyk,
Michael Beer ,
Michael A. L. Limb,
Charlotte A. Jones,
James Spencer ,
Marc W. van der Kamp ,
Adrian J. Mulholland
,
Michael A. L. Limb,
Charlotte A. Jones,
James Spencer ,
Marc W. van der Kamp ,
Adrian J. Mulholland
QM/MM Simulations Reveal the Determinants of Carbapenemase Activity in Class A β-Lactamases
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2021
Jürgen Brem ,
Tharindi Panduwawala ,
Jon Ulf Hansen,
Joanne Hewitt,
Edgars Liepins,
Pawel Donets ,
Laura Espina,
Alistair J. M. Farley,
Kirill Shubin,
Gonzalo Gomez Campillos ,
Paula Kiuru ,
Shifali Shishodia ,
Daniel Krahn,
Robert K. Leśniak,
Juliane Schmidt
and 46 other authors
,
Tharindi Panduwawala ,
Jon Ulf Hansen,
Joanne Hewitt,
Edgars Liepins,
Pawel Donets ,
Laura Espina,
Alistair J. M. Farley,
Kirill Shubin,
Gonzalo Gomez Campillos ,
Paula Kiuru ,
Shifali Shishodia ,
Daniel Krahn,
Robert K. Leśniak,
Juliane Schmidt
and 46 other authors
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors
Download from www.nature.com
Agata Butryn ,
Philipp S. Simon ,
Pierre Aller ,
Philip Hinchliffe ,
Ramzi N. Massad,
Gabriel Leen,
Catherine L. Tooke ,
Isabel Bogacz,
In-Sik Kim,
Asmit Bhowmick,
Aaron S. Brewster ,
Nicholas E. Devenish,
Jürgen Brem ,
Jos J. A. G. Kamps ,
Pauline A. Lang
and 21 other authors
,
Philipp S. Simon ,
Pierre Aller ,
Philip Hinchliffe ,
Ramzi N. Massad,
Gabriel Leen,
Catherine L. Tooke ,
Isabel Bogacz,
In-Sik Kim,
Asmit Bhowmick,
Aaron S. Brewster ,
Nicholas E. Devenish,
Jürgen Brem ,
Jos J. A. G. Kamps ,
Pauline A. Lang
and 21 other authors
An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography
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Anka Lucic,
Philip Hinchliffe ,
Tika R. Malla,
Catherine L. Tooke ,
Jürgen Brem,
Karina Calvopiña,
Christopher T. Lohans,
Patrick Rabe,
Michael A. McDonough ,
Timothy Armistead,
Allen M. Orville ,
James Spencer ,
Christopher J. Schofield
,
Tika R. Malla,
Catherine L. Tooke ,
Jürgen Brem,
Karina Calvopiña,
Christopher T. Lohans,
Patrick Rabe,
Michael A. McDonough ,
Timothy Armistead,
Allen M. Orville ,
James Spencer ,
Christopher J. Schofield
Faropenem reacts with serine and metallo-β-lactamases to give multiple products
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Maria-Agustina Rossi ,
Veronica Martinez ,
Philip Hinchliffe ,
Maria-Fernanda Mojica ,
Valerie Castillo,
Diego Martín Moreno ,
Ryan Smith,
Brad Spellberg,
George L. Drusano,
Claudia Banchio,
Robert A. Bonomo,
James Spencer ,
Alejandro J. Vila ,
Graciela Mahler
Download from doi.org
,
Veronica Martinez ,
Philip Hinchliffe ,
Maria-Fernanda Mojica ,
Valerie Castillo,
Diego Martín Moreno ,
Ryan Smith,
Brad Spellberg,
George L. Drusano,
Claudia Banchio,
Robert A. Bonomo,
James Spencer ,
Alejandro J. Vila ,
Graciela Mahler
Download from doi.org
2019
Alen Krajnc ,
Jürgen Brem ,
Philip Hinchliffe ,
Karina Calvopiña,
Tharindi D. Panduwawala,
Pauline A. Lang ,
Jos J. A. G. Kamps,
Jonathan M. Tyrrell,
Emma Widlake,
Benjamin G. Saward,
Timothy R. Walsh,
James Spencer ,
Christopher J. Schofield
,
Jürgen Brem ,
Philip Hinchliffe ,
Karina Calvopiña,
Tharindi D. Panduwawala,
Pauline A. Lang ,
Jos J. A. G. Kamps,
Jonathan M. Tyrrell,
Emma Widlake,
Benjamin G. Saward,
Timothy R. Walsh,
James Spencer ,
Christopher J. Schofield
Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases
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Catherine L. Tooke ,
Philip Hinchliffe ,
Pauline A. Lang ,
Adrian J. Mulholland ,
Jürgen Brem ,
Christopher J. Schofield ,
James Spencer
,
Philip Hinchliffe ,
Pauline A. Lang ,
Adrian J. Mulholland ,
Jürgen Brem ,
Christopher J. Schofield ,
James Spencer
Molecular Basis of Class A β-Lactamase Inhibition by Relebactam
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Lindsay E. Evans ,
Aishwarya Krishna,
Yajing Ma,
Thomas E. Webb,
Dominic C. Marshall,
Catherine L. Tooke ,
James Spencer ,
Thomas B. Clarke,
Alan Armstrong ,
Andrew M. Edwards
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,
Aishwarya Krishna,
Yajing Ma,
Thomas E. Webb,
Dominic C. Marshall,
Catherine L. Tooke ,
James Spencer ,
Thomas B. Clarke,
Alan Armstrong ,
Andrew M. Edwards
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2018
Philip Hinchliffe ,
Carol A. Tanner,
Anthony P. Krismanich,
Geneviève Labbé ,
Valerie J. Goodfellow,
Laura Marrone,
Ahmed Y. Desoky,
Karina Calvopiña ,
Emily E. Whittle,
Fanxing Zeng,
Matthew B. Avison,
Niels C. Bols,
Stefan Siemann,
James Spencer ,
Gary I. Dmitrienko
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,
Carol A. Tanner,
Anthony P. Krismanich,
Geneviève Labbé ,
Valerie J. Goodfellow,
Laura Marrone,
Ahmed Y. Desoky,
Karina Calvopiña ,
Emily E. Whittle,
Fanxing Zeng,
Matthew B. Avison,
Niels C. Bols,
Stefan Siemann,
James Spencer ,
Gary I. Dmitrienko
Download from pubs.acs.org
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