Published in
American Society of Hematology, Blood, p. blood-2016-11-750612
DOI: 10.1182/blood-2016-11-750612
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Neutral tumor evolution in myeloma is associated with poor prognosis
Journal article published in 2017 by
David C. Johnson 
,
Oleg Lenive,
Jonathan Mitchell,
Graham Jackson,
Roger Owen,
Mark Drayson,
Gordon Cook,
John R. Jones,
Charlotte Pawlyn,
Faith E. Davies,
Brian A. Walker ,
Christopher Wardell,
Walter M. Gregory,
David Cairns,
Gareth J. Morgan
and other authors.
,
Oleg Lenive,
Jonathan Mitchell,
Graham Jackson,
Roger Owen,
Mark Drayson,
Gordon Cook,
John R. Jones,
Charlotte Pawlyn,
Faith E. Davies,
Brian A. Walker ,
Christopher Wardell,
Walter M. Gregory,
David Cairns,
Gareth J. Morgan
and other authors.
This paper is available in a repository.
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Abstract
Key Points A significant proportion of MM is dominated by neutral evolutionary dynamics. Neutral MM tumors are characterized by shorter survival, consistent with reduced sensitivity to drugs targeting the MM microenvironment.