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TB meningitis in HIV-positive patients in Europe and Argentina: clinical outcome and factors associated with mortality.
,
Anna Vassilenko,
Aza Rakhmanova,
Indra Zeltina,
Mh Losso,
Rf Miller,
Fa Post,
Jm Miro,
Enrico Girardi ,
Joan Caylá,
Mathias Bruyand,
Hansjakob Furrer
and other authors.
Abstract
Objectives. The study aimed at describing characteristics and outcome of tuberculous meningitis (TBM) in HIV-positive patients and comparing these parameters with those of extrapulmonary TB (TBEP) and pulmonary TB (TBP). Methods. Kaplan-Meier estimation and Poisson regression models were used to assess the mortality following TB diagnosis and to evaluate potential prognostic factors for the 3 groups of TB patients separately. Results. A total of 100 patients with TBM, 601 with TBEP, and 371 TBP were included. Patients with TBM had lower CD4 cell counts and only 17.0% received antiretroviral therapy (ART) at TB diagnosis. The cumulative probability of death at 12 months following TB was 51.2% for TBM (95% CI 41.4–61.6%), 12.3% for TBP (8.9–15.7%), and 19.4% for TBEP (16.1–22.6) (P