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American Society for Microbiology, Journal of Clinical Microbiology, 6(48), p. 2237-2239, 2010

DOI: 10.1128/jcm.00662-10

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CagA and VacA Polymorphisms Are Associated with Distinct Pathological Features in Helicobacter pylori-Infected Adults with Peptic Ulcer and Non-Peptic Ulcer Disease

Journal article published in 2010 by Effrosini G. Panayotopoulou, Dionyssios N. Sgouras, Konstantinos S. Papadakos, Kalliopi Petraki, Sébastien Breurec, Spyros Michopoulos, Gerassimos Mantzaris, George Papatheodoridis ORCID, Andreas Mentis, Athanasios Archimandritis
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Polymorphic variability in Helicobacter pylori factors CagA and VacA contributes to bacterial virulence. The presence of one CagA EPIYA-C site is an independent risk factor for gastroduodenal ulceration (odds ratio [OR], 4.647; 95% confidence interval [CI], 2.037 to 10.602), while the presence of the vacA i1 allele is a risk factor for increased activity (OR, 5.310; 95% CI, 2.295 to 12.287) and severity of gastritis (OR, 3.862; 95% CI, 1.728 to 8.632).