Published in
American Society of Hematology, Blood Advances, 3(2), p. 240-251, 2018
DOI: 10.1182/bloodadvances.2017011171
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Soluble GPVI is elevated in injured patients: shedding is mediated by fibrin activation of GPVI
Journal article published in 2018 by
Samantha J. Montague 
,
Céline Delierneux ,
Christelle Lecut,
Nathalie Layios,
Robert J. Dinsdale,
Christine S.-M. Lee ,
Natalie S. Poulter ,
Robert K. Andrews ,
Peter Hampson,
Christopher M. Wearn,
Nathalie Maes,
Jonathan Bishop ,
Amy Bamford ,
Chris Gardiner ,
Woei Ming Lee
and other authors.
,
Céline Delierneux ,
Christelle Lecut,
Nathalie Layios,
Robert J. Dinsdale,
Christine S.-M. Lee ,
Natalie S. Poulter ,
Robert K. Andrews ,
Peter Hampson,
Christopher M. Wearn,
Nathalie Maes,
Jonathan Bishop ,
Amy Bamford ,
Chris Gardiner ,
Woei Ming Lee
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key Points Soluble GPVI is elevated in patients with thermal injury with sepsis, and sGPVI levels augment severity score prediction of mortality. The GPVI ligand, fibrin, induces GPVI shedding without requirement for platelet activation or signaling