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Cold Spring Harbor Laboratory Press, Genes & Development, 23(25), p. 2423-2428, 2011

DOI: 10.1101/gad.181487.111

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SOX after SOX: SOXession regulates neurogenesis

Journal article published in 2011 by Michael Wegner ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Vertebrate embryonic stem (ES) cells give rise to many different cell types in multistep processes. These involve the establishment of a competent state, specification, differentiation, and maturation, and often involve Sox transcription factors. In this issue of Genes & Development, Bergsland and colleagues (pp. 2453–2464) determine the genome-wide binding profile of Sox2, Sox3, and Sox11 as ES cells become specified to neural precursors and differentiate into neurons. An ordered, sequential binding of these Sox proteins to a common set of gene enhancers was found to drive neurogenesis, as Sox proteins first help to preselect neural genes in ES cells and later ensure their proper activation in neural precursors or neurons.