Published in
American Society of Hematology, Blood Advances, 6(1), p. 341-351, 2017
DOI: 10.1182/bloodadvances.2016002980
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Th17 plasticity and transition toward a pathogenic cytokine signature are regulated by cyclosporine after allogeneic SCT
Journal article published in 2017 by
Kate H. Gartlan 
,
Antiopi Varelias,
Motoko Koyama,
Renee J. Robb,
Kate A. Markey,
Karshing Chang,
Andrew N. Wilkinson,
David Smith,
Md Ashik Ullah,
Rachel D. Kuns,
Neil C. Raffelt,
Stuart D. Olver,
Katie E. Lineburg,
Bianca E. Teal,
Melody Cheong
and other authors.
,
Antiopi Varelias,
Motoko Koyama,
Renee J. Robb,
Kate A. Markey,
Karshing Chang,
Andrew N. Wilkinson,
David Smith,
Md Ashik Ullah,
Rachel D. Kuns,
Neil C. Raffelt,
Stuart D. Olver,
Katie E. Lineburg,
Bianca E. Teal,
Melody Cheong
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key Points Th17 cells differentiate early after allo-SCT in both mouse and man and display a high degree of cytokine plasticity. IL-12/IL-23 drives further differentiation of Th17 toward an inflammatory phenotype that is inhibited by cyclosporine treatment.