Prevalence of sexual dimorphism in mammalian phenotypic traits

Karp, Natasha A.; Seavitt, John R.; Smedley, Damian; Sorg, Tania; Speak, Anneliese O.; Steel, Karen P.; Svenson, Karen L.; Suzuki, Tomohiro; Tamura, Masaru; Yamada, Ikuko; Tanaka, Nobuhiko; Yoshiki, Atsushi; Tolentino, Heather A.; Tolentino, Todd; Vukobradovic, Igor; Shang, Xueyuan; Wang, Yanchun; Zhu, Yingchun; Sohel, Khondoker; Tondat, Sandra; Sleep, Gillian; Teboul, Lydia; Szoke-Kovacs, Zsombor; Stewart, Michelle; Sinclair, Caroline; Wardle-Jones, Hannah; Woods, Mike; Tudor, Catherine L.; Tuck, Elizabeth J.; Siragher, Emma J.; Vancollie, Valerie E.; Shannon, Carl; Sumowski, Maksymilian T.; Swiatkowska, Agnieszka; Wilson, Heather M.; Vasseur, Laurent; Treise, Irina; Stoeger, Tobias; Wurst, Wolfgang; Steinkamp, Ralph; Östereicher, Manuela A.; Stoeger, Claudia; Yildrim, AliÖ; Zimprich, Annemarie; Seisenberger, Claudia; Zimmer, Andreas; Wolf, Eckhard; Wakana, Shigeharu; West, David; Wells, Sara; Westerberg, Henrik; Yaacoby, Shay; White, Jacqueline K.; Meehan, Terrence F.; Mott, Richard F.; Murray, Stephen A.; Parkinson, Helen; Ramirez-Solis, Ramiro; Santos, Luis; Na, Karp; Mason, Jeremy; Obata, Yuichi; Miura, Ikuo; Guo, Shiying; Greenaway, Simon; Heller, Ruth; Herault, Yann; Justice, Monica J.; Schuchbauer, Michael A.; Kurbatova, Natalja; Lelliott, Christopher J.; Pedroia, Sheryl M.; Lloyd, K. C. Kent; Mallon, Ann-Marie; Owen, Celeste; Mank, Judith E.; Qu, Dawei; Masuya, Hiroshi; Newbigging, Susan; Al, Beaudet; Morikawa, Lily; McKerlie, Colin; Kaneda, Hideki; Nutter, Lauryl M. J.; Penton, Patricia; Kobayashi, Kimio; Miller, David; Kelsey, Lois; Pereira, Monica; Guo, Ruolin; Law, Napoleon; Radage, Adam; Laurin, Valerie; Mianne, Joffrey; Lan, Qing; Hunter, Jane; MacMaster, Suzanne; Gertsenstein, Marina; Melvin, David G.; Raj, Navis P. S.; Jacob, Elsa; Loeffler, Jorik; Johnson, Sara; Pearson, Selina A.; Re, Braun; Sanderson, Mark; Maritati, Marina; McLaren, Robbie S. B.; Keskivali-Bond, Piia; Grau, Evelyn; Griggs, Nicola; Roberson, Laura-Anne; Kundi, Helen; Pavlovic, Guillaume; Griffiths, Mark N. D.; Sdm, Brown; Kipp, Christian; Holroyd, Simon A.; Benjamini, Yoav; Hooks, Yvette E.; Moreth, Kristin; Green, Angela L.; Kussy, Fiona L.; Neff, Frauke; Maguire, Simon A.; Bower, Lynette; Lafont, David T.; Ej, Chesler; Ollert, Markus; Gates, Amy S.; Isherwood, Christopher M.; Mazzeo, Cecilia Icoresi; Lillistone, Charlotte; Maguire, Anna Karin B.; Marie, Wattenhofer-Donze; Jacquot, Sylvie; Me, Dickinson; Schmidt-Weber, Carsten; Le Marchand, Elise; Rathkolb, Birgit; Rozman, Jan; Klopstock, Thomas; Marschall, Susan; Am, Flenniken; Lengger, Christoph; Maier, Holger; Leuchtenberger, Stefanie; Hölter, Sabine M.; Graw, Jochen; Klingenspor, Martin; Braun, Robert E.; Brown, Steve D. M.; Chesler, Elissa J.; Dickinson, Mary E.; Flenniken, Ann M.; Fuchs, Helmut; Furuse, Tamio; Clary, David A.; Berberovic, Zorana; Feugas, Patricia; Eskandarian, Mohammad; Clarke, Shannon; Clark, Greg; Cabezas, Jorge; Bubshait, Mohammed; Carroll, Tracy; Danisment, Ozge; Mh, Angelis; Creighton, Amie; Gao, Xiang; Clark, James; Fray, Martin; Caulder, Adam; Codner, Gemma; Cleak, James; Gardiner, Wendy; Cater, Heather; Brown, Ellen; Doe, Brendan; Gannon, David J.; Galli, Antonella; Cambridge, Emma L.; Caetano, Susana S.; Dabrowska, Monika H.; Estabel, Jeanne; Birling, Marie-Christine; Charles, Philippe; El Amri, Amal; Bekeredjian, Raffi; Calzada-Wack, Julia; Brommage, Robert; Bürger, Antje; Eickelberg, Oliver; Busch, Dirk H.; Gailus-Durner, Valérie; Beckers, Johannes; Guo, S.; Beaudet, Arthur L.; Angelis, Martin Hrabe de; Garrett, Lillian; Ayabe, Shinya; Aprile, Joseph Anthony; Allen, Susan; Alcantara, Rafael; Anthony, Lauren F. E.; Ayadi, Abdel; Ali-Hadji, Dalila; André, Philippe; Aguilar-Pimentel, Antonio; Amarie, Oana V.; Becker, Lore; Jk, White

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Yann Herault
Karp et al., 2017

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Nature Research, Nature Communications, 1(8), 2017

DOI: 10.1038/ncomms15475

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@article{Karp2017,
  abstract = {AbstractThe role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.},
  author = {Karp, Natasha A. and Seavitt, John R. and Smedley, Damian and Sorg, Tania and Speak, Anneliese O. and Steel, Karen P. and Svenson, Karen L. and Suzuki, Tomohiro and Tamura, Masaru and Yamada, Ikuko and Tanaka, Nobuhiko and Yoshiki, Atsushi and Tolentino, Heather A. and Tolentino, Todd and Vukobradovic, Igor and Shang, Xueyuan and Wang, Yanchun and Zhu, Yingchun and Sohel, Khondoker and Tondat, Sandra and Sleep, Gillian and Teboul, Lydia and Szoke-Kovacs, Zsombor and Stewart, Michelle and Sinclair, Caroline and Wardle-Jones, Hannah and Woods, Mike and Tudor, Catherine L. and Tuck, Elizabeth J. and Siragher, Emma J. and Vancollie, Valerie E. and Shannon, Carl and Sumowski, Maksymilian T. and Swiatkowska, Agnieszka and Wilson, Heather M. and Vasseur, Laurent and Treise, Irina and Stoeger, Tobias and Wurst, Wolfgang and Steinkamp, Ralph and Östereicher, Manuela A. and Stoeger, Claudia and Yildrim, AliÖ and Zimprich, Annemarie and Seisenberger, Claudia and Zimmer, Andreas and Wolf, Eckhard and Wakana, Shigeharu and West, David and Wells, Sara and Westerberg, Henrik and Yaacoby, Shay and White, Jacqueline K. and Meehan, Terrence F. and Mott, Richard F. and Murray, Stephen A. and Parkinson, Helen and Ramirez-Solis, Ramiro and Santos, Luis and Na, Karp and Mason, Jeremy and Obata, Yuichi and Miura, Ikuo and Guo, Shiying and Greenaway, Simon and Heller, Ruth and Herault, Yann and Justice, Monica J. and Schuchbauer, Michael A. and Kurbatova, Natalja and Lelliott, Christopher J. and Pedroia, Sheryl M. and Lloyd, K. C. Kent and Mallon, Ann-Marie and Owen, Celeste and Mank, Judith E. and Qu, Dawei and Masuya, Hiroshi and Newbigging, Susan and Al, Beaudet and Morikawa, Lily and McKerlie, Colin and Kaneda, Hideki and Nutter, Lauryl M. J. and Penton, Patricia and Kobayashi, Kimio and Miller, David and Kelsey, Lois and Pereira, Monica and Guo, Ruolin and Law, Napoleon and Radage, Adam and Laurin, Valerie and Mianne, Joffrey and Lan, Qing and Hunter, Jane and MacMaster, Suzanne and Gertsenstein, Marina and Melvin, David G. and Raj, Navis P. S. and Jacob, Elsa and Loeffler, Jorik and Johnson, Sara and Pearson, Selina A. and Re, Braun and Sanderson, Mark and Maritati, Marina and McLaren, Robbie S. B. and Keskivali-Bond, Piia and Grau, Evelyn and Griggs, Nicola and Roberson, Laura-Anne and Kundi, Helen and Pavlovic, Guillaume and Griffiths, Mark N. D. and Sdm, Brown and Kipp, Christian and Holroyd, Simon A. and Benjamini, Yoav and Hooks, Yvette E. and Moreth, Kristin and Green, Angela L. and Kussy, Fiona L. and Neff, Frauke and Maguire, Simon A. and Bower, Lynette and Lafont, David T. and Ej, Chesler and Ollert, Markus and Gates, Amy S. and Isherwood, Christopher M. and Mazzeo, Cecilia Icoresi and Lillistone, Charlotte and Maguire, Anna Karin B. and Marie, Wattenhofer-Donze and Jacquot, Sylvie and Me, Dickinson and Schmidt-Weber, Carsten and Le Marchand, Elise and Rathkolb, Birgit and Rozman, Jan and Klopstock, Thomas and Marschall, Susan and Am, Flenniken and Lengger, Christoph and Maier, Holger and Leuchtenberger, Stefanie and Hölter, Sabine M. and Graw, Jochen and Klingenspor, Martin and Braun, Robert E. and Brown, Steve D. M. and Chesler, Elissa J. and Dickinson, Mary E. and Flenniken, Ann M. and Fuchs, Helmut and Furuse, Tamio and Clary, David A. and Berberovic, Zorana and Feugas, Patricia and Eskandarian, Mohammad and Clarke, Shannon and Clark, Greg and Cabezas, Jorge and Bubshait, Mohammed and Carroll, Tracy and Danisment, Ozge and Mh, Angelis and Creighton, Amie and Gao, Xiang and Clark, James and Fray, Martin and Caulder, Adam and Codner, Gemma and Cleak, James and Gardiner, Wendy and Cater, Heather and Brown, Ellen and Doe, Brendan and Gannon, David J. and Galli, Antonella and Cambridge, Emma L. and Caetano, Susana S. and Dabrowska, Monika H. and Estabel, Jeanne and Birling, Marie-Christine and Charles, Philippe and El Amri, Amal and Bekeredjian, Raffi and Calzada-Wack, Julia and Brommage, Robert and Bürger, Antje and Eickelberg, Oliver and Busch, Dirk H. and Gailus-Durner, Valérie and Beckers, Johannes and Guo, S. and Beaudet, Arthur L. and Angelis, Martin Hrabe de and Garrett, Lillian and Ayabe, Shinya and Aprile, Joseph Anthony and Allen, Susan and Alcantara, Rafael and Anthony, Lauren F. E. and Ayadi, Abdel and Ali-Hadji, Dalila and André, Philippe and Aguilar-Pimentel, Antonio and Amarie, Oana V. and Becker, Lore and Jk, White},
  doi = {10.1038/ncomms15475},
  journal = {Nature Communications},
  month = {jun},
  title = {Prevalence of sexual dimorphism in mammalian phenotypic traits},
  url = {http://dx.doi.org/10.1038/ncomms15475},
  volume = {8},
  year = {2017}
}

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