Summary An iterative mixed-methods research cycle is proposed as an approach to automatically querying the Semantic Web. To give an indication of what codification of this iterative research cycle could look like in practice, a dynamic iterator pipeline is presented that has been developed for efficient and effective iterative queries of the Semantic Web. The development of the logic of the iterative research cycle could be advanced by providing detailed and systematic answers to the question of how researchers go about answering questions by combining information from different sources on the Web.