Purpose The case of a 71-year-old man who complained of progressive, unilateral visual blurring following vitrectomy for retinal detachment due to opacification of his Rayner Centerflex 570H intraocular lens (IOL) implant is reported. Intraocular lens exchange was carried out and the explanted lens analyzed. The same model lens in his fellow eye has remained clear. Methods Clinicopathologic case report. Results Scanning electron microscopy and energy-dispersive x-ray analysis confirmed the presence of hydroxyapatite deposits within the anterior surface of the IOL. Conclusions To our knowledge, this is the first clinicopathologic case report of calcification of this model IOL in an adult patient. The sequence of events, unilaterality and pathologic findings suggest secondary calcification, which could have been related to severe postoperative inflammation and associated blood-aqueous barrier breakdown.