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Oxford University Press, Nucleic Acids Research, 2(45), p. e9-e9, 2016

DOI: 10.1093/nar/gkw852

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Flexible expressed region analysis for RNA-seq with derfinder

Journal article published in 2017 by Leonardo Collado-Torres ORCID, Abhinav Nellore ORCID, Alyssa C. Frazee, Christopher Wilks, Michael I. Love, Ben Langmead, Rafael A. Irizarry, Jeffrey T. Leek, Andrew E. Jaffe
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Differential expression analysis of RNA sequencing (RNA-seq) data typically relies on reconstructing transcripts or counting reads that overlap known gene structures. We previously introduced an intermediate statistical approach called differentially expressed region (DER) finder that seeks to identify contiguous regions of the genome showing differential expression signal at single base resolution without relying on existing annotation or potentially inaccurate transcript assembly.