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Annual Reviews, Annual Review of Biophysics, 1(38), p. 173-196, 2009

DOI: 10.1146/annurev.biophys.050708.133728

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Imaging Transcription in Living Cells

Journal article published in 2009 by Xavier Darzacq, Jie Yao, Daniel R. Larson, Sebastien Z. Causse, Lana Bosanac, Valeria de Turris ORCID, Vera M. Ruda, Timothee Lionnet ORCID, Daniel Zenklusen ORCID, Benjamin Guglielmi, Robert Tjian, Robert H. Singer
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The advent of new technologies for the imaging of living cells has made it possible to determine the properties of transcription, the kinetics of polymerase movement, the association of transcription factors, and the progression of the polymerase on the gene. We report here the current state of the field and the progress necessary to achieve a more complete understanding of the various steps in transcription. Our Consortium is dedicated to developing and implementing the technology to further this understanding.