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Wiley Open Access, Molecular Systems Biology, 1(8), p. 572, 2012

DOI: 10.1038/msb.2012.3

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Genes adopt non-optimal codon usage to generate cell cycle-dependent oscillations in protein levels

Journal article published in 2012 by Milana Frenkel-Morgenstern, Tamar Danon, Thomas Christian, Takao Igarashi, Lydia Cohen, Ya-Ming Hou, Lars Juhl Jensen ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Most cell cycle-regulated genes adopt non-optimal codon usage, namely, their translation involves wobbly matching codons. Here, the authors show that tRNA expression is cyclic and that codon usage, therefore, can give rise to cell-cycle regulation of proteins.