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Wiley, Angewandte Chemie International Edition, 7(54), p. 2057-2061, 2015

DOI: 10.1002/anie.201409124

Wiley, Angewandte Chemie, 7(127), p. 2085-2089, 2015

DOI: 10.1002/ange.201409124

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Affinity Enhancement by Dendritic Side Chains in Synthetic Carbohydrate Receptors**

Journal article published in 2015 by Harry Destecroix, Charles M. Renney, Tiddo J. Mooibroek, Tom S. Carter ORCID, Patrick F. N. Stewart, Matthew P. Crump, Anthony P. Davis
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Dendritic side chains have been used to modify the binding environment in anthracene-based synthetic carbohydrate receptors. Control of length, charge, and branching enabled the positioning of side-chain carboxylate groups in such a way that they assisted in binding substrates rather than blocking the cavity. Conformational degeneracy in the dendrimers resulted in effective preorganization despite the flexibility of the system. Strong binding was observed to glucosammonium ions in water, with Ka values up to 7000 m−1. Affinities for uncharged substrates (glucose and N-acetylglucosamine) were also enhanced, despite competition from solvent and the absence of electrostatic interactions.