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American Society for Clinical Investigation, Journal of Clinical Investigation, 5(119), p. 1074-1076

DOI: 10.1172/jci39071

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New roles revealed for T cells and DCs in glomerulonephritis

Journal article published in 2009 by Alfred H. J. Kim, Mary A. Markiewicz, Andrey S. Shaw ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Little is known about the potential role of T cells in the inflammatory renal disease glomerulonephritis (GN). GN has been historically viewed as a product of immune complex–mediated complement activation, and the presence of autoantibodies made identifying T cell–specific effector contributions difficult to elucidate. In this issue of the JCI, Heymann et al. generate what they believe to be a novel, transgenic murine model of GN, demonstrating a direct role for CD8+ T cells, activated CD4+ T cells, and DCs in the pathogenesis of GN (see the related article beginning on page 1286).