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Hindawi, Journal of Obesity, (2016), p. 1-7, 2016

DOI: 10.1155/2016/6170719

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A Systematic Review and Meta-Analysis of Outcomes for Type 1 Diabetes after Bariatric Surgery

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background. The utility of bariatric surgery in type 1 diabetes remains controversial. The aim of the present study is to evaluate glycemic control outcomes in obese patients with type 1 diabetes after bariatric surgery.Methods. A comprehensive search of electronic databases was completed. Inclusion criteria included human adult subjects with BMI ≥35 kg/m2and a confirmed diagnosis of type 1 diabetes who underwent a bariatric surgical procedure.Results. Thirteen primary studies (86 patients) were included. Subjects had a mean age of41.16±6.76years with a mean BMI of42.50±2.65 kg/m2. There was a marked reduction in BMI postoperatively at 12 months and at study endpoint to29.55±1.76 kg/m2(P<0.00001) and30.63±2.09 kg/m2(P<0.00001), respectively. Preoperative weighted mean total daily insulin requirement was98±26 IU/d, which decreased significantly to36±15 IU/d (P<0.00001) and42±11 IU/d (P<0.00001) at 12 months and at study endpoint, respectively. An improvement inHbA1cwas also seen from8.46±0.78% preoperatively to7.95±0.55% (P=0.01) and8.13±0.86% (P=0.03) at 12 months and at study endpoint, respectively.Conclusion. Bariatric surgery in patients with type 1 diabetes leads to significant reductions in BMI and improvements in glycemic control.