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BMJ Publishing Group, Journal of Medical Genetics, 12(53), p. 835-845, 2016

DOI: 10.1136/jmedgenet-2016-103966

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Meta-analysis of genome-wide association studies of HDL cholesterol response to statins

Journal article published in 2016 by Iris Postmus, D. (Douwe) Postmus, Helen R. Warren, Stella Trompet, Benoit J. (Benoit J.) Arsenault, Christy L. Avery, Joshua C. (Joshua) Bis, Daniel I. (Daniel) Chasman, Catherine E. de Keyser, Harshal A. Deshmukh, C. E. (Catherina Elisabeth) de Keyser, Daniel S. (Daniel) Evans, QiPing Feng, Xiaohui Li, Roelof A. J. (Roelof A. J.) Smit and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Background: In addition to lowering low density lipoprotein cholesterol (LDL-C), statin therapy also raises high density lipoprotein cholesterol (HDL-C) levels. Inter-individual variation in HDL-C response to statins may be partially explained by genetic variation. Methods and results: We performed a meta-analysis of genome-wide association studies (GWAS) to identify variants with an effect on statin-induced high density lipoprotein cholesterol (HDL-C) changes. The 123 most promising signals with p