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Theoretical implications of a pre-erythrocytic Plasmodium vivax vaccine for preventing relapses

Journal article published in 2017 by Mt White ORCID, Rogerio Amino, Ivo Mueller
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Preventing malaria infection through vaccination requires preventing every sporozoite inoculated by mosquito bite: a major challenge for Plasmodium falciparum. Plasmodium vivax sporozoites consist of tachysporozoites causing primary infection and bradysporozoites leading to relapses.We hypothesise that a candidate P. vivax vaccine with low efficacy against primary infection may substantially reduce transmission by preventing relapses.